US4039558A
Expired / Lapsed
US
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Amino-substituted tetracyclic compounds
Assignee: Akzona Inc
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Filing: 1975-10-20
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Granted: 1977-08-02
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Expires: 1995-10-20
Abstract
Abstract The invention is dealing with compounds of the general formula: ##STR1## as well as the pharmaceutically acceptable salts thereof, in which X represents oxygen, sulphur, the group >NR 7 or the group --CR 8 R 9 --, R 1 , r 2 , r 3 and R 4 represent hydrogen, hydroxy, halogen, an alkyl, alkoxy or alkylthio group or a trifluoromethyl group, R 5 and R 6 represent hydrogen, an alkyl group or an aralkyl group, R 7 represents hydrogen or alkyl (1-4 C), R 8 , r 9 represent hydrogen or methyl, and Q represents hydrogen (2H) or oxygen, Having valuable antihistamine, sedative and antidepressive properties.
Inventors
- 👤 Willem Jacob van der Burg
- 👤 Robert Raymond Malvine Salsmans
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 12:08
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
123 words
A compound of the formula: or a pharmaceutically acceptable salt thereof, in which X represents oxygen, sulfur, the group > NR 7 or the group --CR 8 R 9 --, Q represents hydrogen (2H) or oxygen, R 1 , r 2 , r 3 , r 4 represent hydrogen, hydroxy, halogen, alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 6 carbon atoms, alkylthio having 1 to 6 carbon atoms or trifluoromethyl, R 5 , r 6 represent hydrogen, alkyl having 1 to 6 carbon atoms or phenylalkyl the alkyl group of which has 1 to 4 carbon atoms, R 7 represents hydrogen or alkyl having 1 to 4 carbon atoms and R 8 , r 9 represent hydrogen or methyl.
Claim 2
Dependent Claim
123 words
A compound of the formula: or a pharmaceutically acceptable salt thereof, in which X represents oxygen, sulfur, the group > NR 7 or the group --CR 8 R 9 --, Q represents hydrogen (2H) or oxygen, R 1 , r 2 , r 3 , r 4 represent hydrogen, hydroxy, halogen, alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 6 carbon atoms, alkylthio having 1 to 6 carbon atoms or trifluoromethyl, R 5 , r 6 represent hydrogen, alkyl having 1 to 6 carbon atoms or phenylalkyl the alkyl group of which has 1 to 4 carbon atoms, R 7 represents hydrogen or alkyl having 1 to 4 carbon atoms and R 8 , r 9 represent hydrogen or methyl.
Claim 3
Dependent Claim
11 words
A compound according to claim 1, in which X is methylene.
Claim 4
Dependent Claim
11 words
A compound according to claim 1, in which X is oxygen.
Claim 5
Dependent Claim
9 words
The cis-stereo-isomer of a compound according to claim 1.
Claim 6
Dependent Claim
7 words
2-Dimethylamino-1,2,3,13b-tetrahydro-pyrrolo[1,2-d]-dibenzo[b,f](1,4)-oxazepine and the pharmaceutically acceptable salts thereof.
Claim 7
Dependent Claim
7 words
2-Dimethylamino-1,2,3,13b-tetrahydro-pyrrolo[1,2-d]-dibenzo[b,f](1,4)-oxazepine and the pharmaceutically acceptable salts thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-01 | 1981-01-31 | 1981-08-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-01 | 1985-01-31 | 1985-08-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-01 | 1989-01-31 | 1989-08-02 | $7700.00 | Window Closed / Lapsed |