US4035374A
Expired / Lapsed
US
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Imidazolyl alkylaminopyridone and pyridinethione compounds
Assignee: Smith Kline & French Laboratories Ltd
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Filing: 1975-10-06
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Granted: 1977-07-12
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Expires: 1995-10-06
Abstract
Abstract Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-4-pyrimidone.
Inventors
- 👤 Graham John Durant
- 👤 John Colin Emmett
- 👤 Charon Robin Ganellin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 19:17
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/66; C07D233/86; C07D233/88; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/46; C07D239/56
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
111 words
A compound 2-amino-4-or 6-pyridone or pyridinethione of the formula: ##STR4## wherein A taken together with the nitrogen and carbon atom shown forms a pyridine ring, said ring having a keto or thione group and optionally substituted by one or two lower alkyl, phenyl or benzyl groups, provided that if two of the optional substituents are present at least one is lower alkyl; R is a grouping of the formula: Het--CH.sub.2 Z(CH.sub.2).sub.n -- wherein Het is an imidazole ring, said ring being optionally substituted by lower alkyl, amino, hydroxy or halogen; Z is sulphur or a methylene group and n is 2 or 3 or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
111 words
A compound 2-amino-4-or 6-pyridone or pyridinethione of the formula: ##STR4## wherein A taken together with the nitrogen and carbon atom shown forms a pyridine ring, said ring having a keto or thione group and optionally substituted by one or two lower alkyl, phenyl or benzyl groups, provided that if two of the optional substituents are present at least one is lower alkyl; R is a grouping of the formula: Het--CH.sub.2 Z(CH.sub.2).sub.n -- wherein Het is an imidazole ring, said ring being optionally substituted by lower alkyl, amino, hydroxy or halogen; Z is sulphur or a methylene group and n is 2 or 3 or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
15 words
A compound of claim 1 wherein Het is an imidazole ring, optionally substituted by methyl.
Claim 4
Dependent Claim
9 words
A compound of claim 1 wherein n is 2.
Claim 5
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-(1H)-pyrid-4-one.
Claim 6
Dependent Claim
64 words
A compound of claim 1 of the following formula: ##STR5## wherein R has the same significance as in claim 1; X is oxygen or sulphur; Y 1 and Y 2 , which may be the same or different, are hydrogen, lower alkyl, phenyl or benzyl, provided that if Y 1 and Y 2 are both other than hydrogen, at least one is lower alkyl.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-11 | 1981-01-10 | 1981-07-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-11 | 1985-01-10 | 1985-07-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-11 | 1989-01-10 | 1989-07-12 | $7700.00 | Window Closed / Lapsed |