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US4034756A Expired / Lapsed US ⏱️ 0.0 years remaining

Osmotically driven fluid dispenser

Assignee: Alza Corp
•
Filing: 1976-03-12
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Granted: 1977-07-12
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Expires: 1996-03-12
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Abstract

Abstract An osmotically driven fluid dispenser for use in an aqueous environment comprising: a shape retaining canister having controlled permeability to water; an osmotically effective solute confined in the canister which, in solution, exhibits an osmotic pressure gradient against the water in the environment; an outlet in the canister wall; and a flexible bag of relatively impervious material that holds the fluid to be dispensed and is housed in the canister with its open end in sealed contact with the canister such that the canister outlet communicates with the bag interior and the bag interior is closed to the solute and aqueous solution thereof with the remainder of the bag spaced from and generally unsupported by the canister wall.

Inventors

  • 👤 Takeru Higuchi
  • 👤 Harold M. Leeper

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 23:02
CPC Classifications
B; B01; B01J; B01J4/00; B01J4/04; A; A01; A01G; A01G7/00; A01G7/06; A61; A61D; A61D7/00; A61K; A61K9/00; A61K9/0002; A61K9/0004; B65; B65D; B65D1/00; B65D1/02; B65D1/04

Claims Analysis

Total Claims: 10
Claim 1
Independent Claim 244 words
An osmotically driven fluid dispenser for use in a surrounding aqueous environment consisting essentially of: a. a single shape retaining closed canister that defines the exterior of the dispenser which exterior is exposed completely to the aqueous environment, at least a part of the wall of the canister being made of a material of controlled permeability to water; b. an osmotically effective solute confined within the canister which, in aqueous solution, exhibits an osmotic pressure gradient across said portion of the canister wall against the water of said environment, said canister being substantially impermeable to the solute; c. an outlet in the canister wall; and d. a flexible bag adapted to hold the fluid to be dispensed and housed within the canister with its open end in sealed contact with a portion of the canister wall such that the outlet communicates with its interior and its interior is closed to the solute and aqueous solution thereof with the remainder of the bag being spaced from the remaining portion of the canister wall and generally unsupported thereby, the exterior of said remainder being exposed to the solute and aqueous solution thereof, whereby water is imbibed into the canister from the environment through said part of the canister wall by the solute and the imbibed water exerts hydraulic pressure uniformly on the exterior of the flexible bag exposed thereto, causing the bag to collapse inwardly thus squeezing the fluid out of the bag via the outlet.
Claim 2
Dependent Claim 244 words
An osmotically driven fluid dispenser for use in a surrounding aqueous environment consisting essentially of: a. a single shape retaining closed canister that defines the exterior of the dispenser which exterior is exposed completely to the aqueous environment, at least a part of the wall of the canister being made of a material of controlled permeability to water; b. an osmotically effective solute confined within the canister which, in aqueous solution, exhibits an osmotic pressure gradient across said portion of the canister wall against the water of said environment, said canister being substantially impermeable to the solute; c. an outlet in the canister wall; and d. a flexible bag adapted to hold the fluid to be dispensed and housed within the canister with its open end in sealed contact with a portion of the canister wall such that the outlet communicates with its interior and its interior is closed to the solute and aqueous solution thereof with the remainder of the bag being spaced from the remaining portion of the canister wall and generally unsupported thereby, the exterior of said remainder being exposed to the solute and aqueous solution thereof, whereby water is imbibed into the canister from the environment through said part of the canister wall by the solute and the imbibed water exerts hydraulic pressure uniformly on the exterior of the flexible bag exposed thereto, causing the bag to collapse inwardly thus squeezing the fluid out of the bag via the outlet.
Claim 3
Dependent Claim 18 words
The dispenser as defined by claim 1 wherein the fluid is an active agent and a bio-affecting composition.
Claim 4
Dependent Claim 14 words
The dispenser as defined by claim 1 wherien the fluid is a drug formulation.
Claim 5
Dependent Claim 28 words
The dispenser as defined by claim 1 wherein the solution of an osmotically effective solute exhibiting an osmotic pressure gradient against water is a saturated aqueous salt solution.
Claim 6
Dependent Claim 18 words
The dispenser as defined by claim 4 wherein the saturated salt solution contains excess solute in solid form.
Claim 7
Dependent Claim 33 words
The dispenser as defined in claim 1 wherein the canister is comprised of a membrane selected from the group consisting of cellulose acetate, silicone rubber, polyurethane, natural rubber and hydrolyzed ethylene/vinyl acetate copolymer.
Claim 8
Dependent Claim 16 words
The dispenser as defined by claim 6; wherein the membrane is an anisotropic reverse osmosis membrane.
Claim 9
Dependent Claim 55 words
The dispenser as defined in claim 1 wherein the osmotically effective solute is selected from the group consisting of magnesium sulphate, magnesium chloride, sodium chloride, potassium sulphate, sodium carbonate, sodium sulphite, sodium sulphate, sodium bicarbonate, potassium acid phthalate, calcium bicarbonate, potassium acid phosphate, raffinose, tartaric acid, succinic acid, calcium succinate, calcium lactate, and magnesium succinate.
Claim 10
Dependent Claim 38 words
The dispenser as defined by claim 1 wherein the flexible bag is comprised of a material selected from the group consisting of polyethylene, polyethylene terephthalate, polylvinvyl chloride, metal-foil polyethylene laminate, neoprene rubber, natural gum rubber and rubber hydrochloride.

References Cited (Backward Citations)

US2962023A Cited
US3561644A Cited
US3556992A Cited
US3604417A Cited
US3760806A Cited
US3760805A Cited
US3760984A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1980-07-11 1981-01-10 1981-07-12 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1984-07-11 1985-01-10 1985-07-12 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1988-07-11 1989-01-10 1989-07-12 $7700.00 Window Closed / Lapsed

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