US4031198A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Technetium-labeled complexes, production and use thereof
Assignee: 3M Co
•
Filing: 1974-05-30
•
Granted: 1977-06-21
•
Expires: 1994-05-30
Abstract
Abstract A radiopharmaceutical kit for complexing a liver-specific agent labeled with technetium-99m comprising (1) a biologically sterile aqueous medium wherein the complex formation occurs, (2) a complexing agent which is a lipophilic mercaptan or thioketal and (3) a pharmaceutically acceptable reducing agent for technetium-99m.
Inventors
- 👤 Richard A. Jackson
- 👤 Theodore F. Bolles
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 20:50
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K2123/00
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
112 words
A stable radiopharmaceutical composition for preparing a biologically sterile liquid aqueous medium containing a liver specific agent labeled with technetium-99m comprising a compound for imparting liver specificity to technetium-99m selected from the group consisting of: N-acetyl penicillamine, 2-mercaptoethylamine, 2-mercaptoethanol, 3-mercaptopropanol, 4-mercaptobutanol, 4-mercapto-2-methyl-2-butanol, 2-mercaptoethylamine, 6,8-dihydrothioctic acid, alpha-thio-2-furan pyruvic acid, p-mercaptobenzoic acid, and mixtures thereof; and a pharmaceutically-acceptable reducing agent for pertechnetate, said compound being present in an amount sufficient to provide a concentration of about 0.5 to about 1000 micromoles per milliliter in said aqueous medium; and said reducing agent being present in an amount sufficient to provide a concentration of about 0.01 to about 100 micromoles per milliliter in said aqueous medium.
Claim 2
Dependent Claim
112 words
A stable radiopharmaceutical composition for preparing a biologically sterile liquid aqueous medium containing a liver specific agent labeled with technetium-99m comprising a compound for imparting liver specificity to technetium-99m selected from the group consisting of: N-acetyl penicillamine, 2-mercaptoethylamine, 2-mercaptoethanol, 3-mercaptopropanol, 4-mercaptobutanol, 4-mercapto-2-methyl-2-butanol, 2-mercaptoethylamine, 6,8-dihydrothioctic acid, alpha-thio-2-furan pyruvic acid, p-mercaptobenzoic acid, and mixtures thereof; and a pharmaceutically-acceptable reducing agent for pertechnetate, said compound being present in an amount sufficient to provide a concentration of about 0.5 to about 1000 micromoles per milliliter in said aqueous medium; and said reducing agent being present in an amount sufficient to provide a concentration of about 0.01 to about 100 micromoles per milliliter in said aqueous medium.
Claim 3
Dependent Claim
37 words
A composition according to claim 1 wherein said reducing agent comprises an oxidizable metal salt selected from the group consisting of a tin (II) salt, an iron (II) salt, a copper (I)/copper (II) couple, and mixtures thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-20 | 1980-12-20 | 1981-06-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-20 | 1984-12-20 | 1985-06-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-20 | 1988-12-20 | 1989-06-21 | $7700.00 | Window Closed / Lapsed |