Radioactive labeling kit

Abstract

Abstract A SINGLE-UNIT LABELING KIT FOR RADIOACTIVELY LABELING BIODEGRADABLE MICROPARTICLES FOR MEDICAL DIAGNOSIS AND THE LIKE COMPRISES, GENERALLY, CONTAINER HAVING AT LEAST ONE OPEN END; A POROUS FILTER PLATE MOUNTED WITHIN THE CONTAINER SEPARATING THE CONTAINER INTO FIRST AND SECOND COMPARTMENTS; A PLURALITY OF BIODEGRADABLE MICROPARTICLES IN THE FIRST COMPARTMENT; A SOLID SOURCE OF HYDROGEN ION IN THE SECOND COMPARTMENT; A REAGENT TABLET IN THE FIRST COMPARTMET, THE TABLET COMPRISING A REDUCING REAGENT AND A NON-REACTIVE, NON-TOXIC WETTING AGENT TO AID IN FORMING A SUSPENSION OF THE MICROPARTICLES WHEN A LIQUID IS INTRODUCED NTO THE CONTAINER; AND MEANS TO TEMPORARILY SEAL THE OPEN END OF THE CONTAINER, SUCH MEANS CAPABLE OF RECEIVING A SYRINGE NEEDLE FOR PLACING A LIQUID IN THE CONTAINER AND FOR THE REMOVAL OF RADIOACTIVELY LABELED MICROPARTICLES. THE MICROPARTICLES ARE LABELED BY INTRODUCING A SOLUTION CONTAINING RADIOACTIVE TECHNETIUM INTO THE END OF THE CONTAINER CARRYING THE SOLID SOURCE OF HYDROGEN ION, ACIDIFYING THE SOLUTION BY PASSING IT THROUGH THE SOLID SOURCE OF HYDROGEN ION AND THROUGH THE POROUS FILTER PLATE INTO THE FIRST COMPARTMENT, AGITATING THE ACIDIFIED SOLUTION TO SUSPEND THE MICROPARTICLES AND DISSOLVE THE REAGENT TABLET, HEATING THE CONTAINER TO COMPLETE THE LABELING REACTION, COOLING THE CONTAINER, AND REMOVING THE SUPERNATANT CONTAINING UNREACTED RADIOACTIVE ELEMENTS AND SPENT REAGENTS, LEAVING THE LABELED MICROPARTICLES BEHIND ON THE POROUS FILTER PLATE WHICH MAY THEREAFTER BE REMOVED FOR USE. D R A W I N G

Inventors

• 👤 David O Kubiatowicz

Bibliographic Details