Patent US4031186A successfully refreshed from Google Patents.
US4031186A
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Arylaminoalkylthioamides
Assignee: Rohm and Haas Co
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Filing: 1975-07-10
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Granted: 1977-06-21
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Expires: 1995-07-10
Abstract
Abstract Arylaminoalkylthioamides and salts thereof wherein the benzene ring is substituted with halo, alkyl, lower alkoxy or 1,3-butadienylene are disclosed. The compounds are prepared by the reaction of the correspondingly substituted arylaminoalkylnitrile with hydrogen sulfide. The products are antisecretory agents useful in the treatment of ulcers.
Inventors
- 👤 Peter deBenneville
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 00:16
CPC Classifications
C; C07; C07C; C07C255/00
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
40 words
A compound having the following formula: ##STR6## wherein R 1 is the same or different radical selected from methyl, methoxy, ethoxy, or chloro and n' is an integer of two or three and the nontoxic, pharmacologically acceptable acid addition salts.
Claim 2
Dependent Claim
40 words
A compound having the following formula: ##STR6## wherein R 1 is the same or different radical selected from methyl, methoxy, ethoxy, or chloro and n' is an integer of two or three and the nontoxic, pharmacologically acceptable acid addition salts.
Claim 3
Dependent Claim
8 words
A compound according to claim 1 named 3-(2,4-dimethylanilino)thiopropionamide.
Claim 4
Dependent Claim
8 words
A compound according to claim 1 named 3-(4-chloro-2-methylanilino)thiopropionamide.
Claim 5
Dependent Claim
8 words
A compound according to claim 1 named 3-(2,4,5-trimethylanilino)thiopropionamide.
Claim 6
Dependent Claim
8 words
A compound according to claim 1 named 3-(2,3-dimethylanilino)thiopropionamide.
Claim 7
Dependent Claim
8 words
A compound according to claim 1 named 3-(3-chloro-2-methylanilino)thiopropionamide.
Claim 8
Independent Claim
84 words
A method for treating a stomach ulcer which comprises administering to a patient in need of such treatment an effective amount of a compound of the formula: ##STR7## wherein A is hydrocarbylene containing from one to three carbon atoms; R is methyl, methoxy, ethoxy, halo or two R radicals on adjacent carbon atoms of the benzene ring may be joined together to form 1,3-butadienylene and n is an integer having a value of two to three or the nontoxic pharmacologically acceptable acid addition salts.
Claim 9
Independent Claim
84 words
A method for treating a stomach ulcer which comprises administering to a patient in need of such treatment an effective amount of a compound of the formula: ##STR7## wherein A is hydrocarbylene containing from one to three carbon atoms; R is methyl, methoxy, ethoxy, halo or two R radicals on adjacent carbon atoms of the benzene ring may be joined together to form 1,3-butadienylene and n is an integer having a value of two to three or the nontoxic pharmacologically acceptable acid addition salts.
Claim 10
Dependent Claim
36 words
The method of claim 7 wherein the active ingredient has the formula: ##STR8## wherein R 1 is the same or different radical selected from methyl or chloro and n' is an integer of two or three.
Claim 11
Dependent Claim
11 words
The method of claim 8 wherein the active ingredient is 3-(2,4-dimethylanilino)thiopropionamide.
Claim 12
Dependent Claim
11 words
The method of claim 8 wherein the active ingredient is 3-(4-chloro-2-methylanilino)thiopropionamide.
Claim 13
Dependent Claim
11 words
The method of claim 8 wherein the active ingredient is 3-(2,4,5-trimethylanilino)thiopropionamide.
Claim 14
Dependent Claim
11 words
The method of claim 8 wherein the active ingredient is 3-(2,3-dimethylanilino)thiopropionamide.
Claim 15
Dependent Claim
11 words
The method of claim 8 wherein the active ingredient is 3-(3-chloro-2-methylanilino)thiopropionamide.
Claim 16
Dependent Claim
56 words
A composition for treating stomach ulcers which comprises an effective amount of the compound has the formula: ##STR9## wherein R 1 is the same or different radicals selected from methoxy, ethoxy, methyl or chloro and n' is an integer of 2 or 3 and the nontoxic, pharmacologically acceptable acid addition salts in a pharmaceutically acceptable carrier.
Claim 17
Dependent Claim
56 words
A composition for treating stomach ulcers which comprises an effective amount of the compound has the formula: ##STR9## wherein R 1 is the same or different radicals selected from methoxy, ethoxy, methyl or chloro and n' is an integer of 2 or 3 and the nontoxic, pharmacologically acceptable acid addition salts in a pharmaceutically acceptable carrier.
Claim 18
Dependent Claim
10 words
The composition of claim 14 wherein the compound is 3-(2,4-dimethylanilino)thiopropionamide.
Claim 19
Dependent Claim
10 words
The composition of claim 14 wherein the compound is 3-(4-chloro-2-methylanilino)thiopropionamide.
Claim 20
Dependent Claim
10 words
The composition of claim 14 wherein the compound is 3-(2,4,5-trimethylanilino)thiopropionamide.
Claim 21
Dependent Claim
10 words
The composition of claim 14 wherein the compound is 3-(2,3-dimethylanilino)thiopropionamide.
Claim 22
Dependent Claim
10 words
The composition of claim 14 wherein the compound is 3-(3-chloro-2-methylanilino)thiopropionamide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-20 | 1980-12-20 | 1981-06-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-20 | 1984-12-20 | 1985-06-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-20 | 1988-12-20 | 1989-06-21 | $7700.00 | Window Closed / Lapsed |