Patent US4031069A successfully refreshed from Google Patents.
US4031069A
Expired / Lapsed
US
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Tetrapeptides
Assignee: Parke Davis and Co LLC
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Filing: 1976-03-01
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Granted: 1977-06-21
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Expires: 1996-03-01
Abstract
Abstract New tetrapeptides having the formula A-R 1 -Ser(benzyl)-Tyr(benzyl)-R 2 -R 3 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl and p-nitrobenzyloxycarbonyl; R 1 is L-Trp, L-Thr(benzyl), L-Met or Gly; Ser(benzyl) is D-Ser(benzyl) or L-Ser(benzyl); Tyr(benzyl) is D-Tyr(benzyl) or L-Tyr(benzyl); R 2 is D-Ala, β-Ala, D-Leu or D-Val; and R 3 is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino.
Inventors
- 👤 Ernest D. Nicolaides
- 👤 Francis John Tinney
- 👤 James Clark French
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 20:05
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/02; C07K5/0202; C07K5/04; C07K5/10; C07K5/1002; C07K5/1005; C07K5/1008; C07K5/1013; C07K5/1024; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/13
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
56 words
A tetrapeptide represented by the formula A-R.sub.1 -Ser(benzyl)-Tyr(benzyl)-R.sub.2 -R.sub.3 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl or p-nitrobenzyloxycarbonyl, R 1 is L-Trp, L-Thr(benzyl), L-Met or Gly; Tyr(benzyl) is L-Tyr(benzyl) or D-Tyr(benzyl), Ser(benzyl) is L-Ser(benzyl) or D-Ser(benzyl), R 2 is D-Ala, β-Ala, D-Leu or D-Val and R 3 is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino.
Claim 2
Dependent Claim
56 words
A tetrapeptide represented by the formula A-R.sub.1 -Ser(benzyl)-Tyr(benzyl)-R.sub.2 -R.sub.3 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl or p-nitrobenzyloxycarbonyl, R 1 is L-Trp, L-Thr(benzyl), L-Met or Gly; Tyr(benzyl) is L-Tyr(benzyl) or D-Tyr(benzyl), Ser(benzyl) is L-Ser(benzyl) or D-Ser(benzyl), R 2 is D-Ala, β-Ala, D-Leu or D-Val and R 3 is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino.
Claim 3
Dependent Claim
11 words
The compound of claim 1 having the name N.sup.α-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-D-seryl-O-benzyl-L-tyrosyl-D-alanine methyl ester.
Claim 4
Dependent Claim
10 words
The compound of claim 1 having the name N.sup.α-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-D-tyrosyl-D-alanine N-ethylamide.
Claim 5
Dependent Claim
10 words
The compound of claim 1 having the name N.sup.α-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-β-alanyl hydrazide.
Claim 6
Dependent Claim
11 words
The compound of claim 1 having the name N.sup.α-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-leucine methyl ester.
Claim 7
Dependent Claim
11 words
The compound of claim 1 having the name N.sup.α-t-Butoxycarbonyl-L-tryptophyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-valine methyl ester.
Claim 8
Dependent Claim
10 words
The compound of claim 1 having the name N.sup.α-Cyclohexylcarbonyl-L-tryptophyl-O-benzyl-D-seryl-O-benzyl-L-tyrosyl-D-alanine N-ethylamide.
Claim 9
Dependent Claim
11 words
The compound of claim 1 having the name N.sup.α-p-Nitrobenzyloxycarbonyl-glycyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-alanine methyl ester.
Claim 10
Dependent Claim
11 words
The compound of claim 1 having the name N.sup.α-t-Butoxycarbonyl-L-methionyl-O-benzyl-L-seryl-O-benzyl-L-tyrosyl-D-alanine methyl ester.
References Cited (Backward Citations)
US3725380A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-20 | 1980-12-20 | 1981-06-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-20 | 1984-12-20 | 1985-06-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-20 | 1988-12-20 | 1989-06-21 | $7700.00 | Window Closed / Lapsed |