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US4029762A
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Lipid A-preparation
Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV
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Filing: 1975-12-22
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Granted: 1977-06-14
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Expires: 1995-12-22
Abstract
Abstract A preparation consisting essentially of lipid A or alkali-treated lipid A sorbed on a particulate organic carrier material and an immunizing agent containing same being useful against diseases caused by gram-negative enterobacteriaceae.
Inventors
- 👤 Chris Galanos
- 👤 Otto Luderitz
- 👤 Otto Westphal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 09:53
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/12; C07K16/1203; C07K16/1228; C07K16/1235; A; A61; A61K; A61K39/00; A61K39/395; A61K39/40; C07K16/1232; A61K38/00; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
33 words
A preparation consisting essentially of a member selected from the group consisting of lipid A and alkali-treated lipid A adsorbed on a water-insoluble particulate organic carrier material having distinct hydrophilic and hydrophobic regions.
Claim 2
Dependent Claim
33 words
A preparation consisting essentially of a member selected from the group consisting of lipid A and alkali-treated lipid A adsorbed on a water-insoluble particulate organic carrier material having distinct hydrophilic and hydrophobic regions.
Claim 3
Dependent Claim
30 words
A preparation as in claim 1, wherein the carrier material is selected from the group consisting of erythrocytes, live apathogenic bacteria, killed bacteria, the cell-walls of killed bacteria and liposomes.
Claim 4
Dependent Claim
15 words
A preparation as in claim 1, wherein the carrier is dispersed in an aqueous medium.
Claim 5
Dependent Claim
11 words
A preparation as in claim 1, wherein said carrier is erythrocytes.
Claim 6
Dependent Claim
15 words
A preparation as in claim 1, wherein said carrier is the cell-walls of killed bacteria.
Claim 7
Dependent Claim
16 words
A preparation as in claim 1, wherein said carrier is gram-negative bacteria or the cell-walls thereof.
Claim 8
Dependent Claim
20 words
A preparation as in claim 6, wherein said bacteria are selected from the group consisting of Salmonella and coli bacteria.
Claim 9
Dependent Claim
12 words
A preparation as in claim 1, wherein said carrier is a liposome.
Claim 10
Dependent Claim
18 words
An immunizing agent consisting essentially of the preparation of claim 1 in an effective amount suitable for injection.
Claim 11
Dependent Claim
12 words
An immunizing agent as in claim 9, wherein said carrier is erythrocytes.
Claim 12
Dependent Claim
16 words
An immunizing agent as in claim 9, wherein said carrier is the cell-walls of killed bacteria.
Claim 13
Dependent Claim
18 words
An immunizing agent as in claim 9, wherein said carrier is gram-negative bacteria or the cell walls thereof.
Claim 14
Dependent Claim
21 words
An immunizing agent as in claim 12, wherein said bacteria are selected from the group consisting of Salmonella and coli bacteria.
Claim 15
Dependent Claim
13 words
An immunizing agent as in claim 9, wherein said carrier is a liposome.
Claim 16
Dependent Claim
40 words
A method for isolating a lipid A antibody which comprises contacting a preparation as claimed in claim 1 with an aqueous liquid containing such an antibody, separating the preparation on which said antibody is adsorbed and desorbing the anti-body therefrom.
Claim 17
Dependent Claim
20 words
The method of claim 15, wherein for desorption the preparation is treated with a buffer solution of pH 1- 4.
References Cited (Backward Citations)
US3185624A
Cited
US3652761A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-13 | 1980-12-13 | 1981-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-13 | 1984-12-13 | 1985-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-13 | 1988-12-13 | 1989-06-14 | $7700.00 | Window Closed / Lapsed |