Patent US2717549A successfully refreshed from Google Patents.
Patent US4027036A successfully refreshed from Google Patents.
US4027036A
Expired / Lapsed
US
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3-Substituted propanoic acid derivatives and pharmaceutical composition
Assignee: Lilly Industries Ltd
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Filing: 1974-04-10
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Granted: 1977-05-31
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Expires: 1994-04-10
Abstract
Abstract The invention provides 3-(2-formyl-3-hydroxy-5-oxocyclopent-1-enyl)-propanoic acid and derivatives thereof having anti-thrombotic activity coupled with low toxicity. Also provided is a method for preparing such compounds by subjecting a 3-[3-hydroxy-5-oxo-2-(β-styryl)cyclopent-1-enyl]-propanoic acid or derivative thereof to oxidative cleavage.
Inventors
- 👤 William Dawson
- 👤 Michael John Foulis
- 👤 Norman James Albert Gutteridge
- 👤 Colin William Smith
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 19:58
CPC Classifications
A; A01; A01N; A01N37/00; A01N37/42
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
46 words
A compound selected from the group consisting of (1) the carboxylic acid of the formula ##STR3## wherein R is hydrogen, C 2-4 acyl or C 2-4 haloacyl (2) 2. its alkali metal salt; (3) its C 1-4 alkyl ester; and (4) its C 1-4 haloalkyl ester.
Claim 2
Dependent Claim
46 words
A compound selected from the group consisting of (1) the carboxylic acid of the formula ##STR3## wherein R is hydrogen, C 2-4 acyl or C 2-4 haloacyl (2) 2. its alkali metal salt; (3) its C 1-4 alkyl ester; and (4) its C 1-4 haloalkyl ester.
Claim 3
Dependent Claim
7 words
The carboxylic acid according to claim 1.
Claim 4
Dependent Claim
9 words
The sodium or potassium salt according to claim 1.
Claim 5
Dependent Claim
19 words
The compound of claim 1, wherein R is selected from the group consisting of acetyl, propionyl, chloroacetyl and 3,3,3-trichloropropionyl.
Claim 6
Dependent Claim
10 words
The compound of claim 1, said compound being 3-(2-formyl-3-hydroxy-5-oxocyclopent-1-enyl)propanoic acid.
Claim 7
Dependent Claim
41 words
A pharmaceutical formulation in dosage unit form adapted for administration, comprising per dosage unit an effective amount within the range 1 to 150 mg/kg of animal body weight of a compound of claim 1, admixed with a pharmaceutically acceptable carrier therefor.
References Cited (Backward Citations)
US3810936A
Cited
US3657316A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-30 | 1980-11-29 | 1981-05-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-30 | 1984-11-29 | 1985-05-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-30 | 1988-11-29 | 1989-05-31 | $7700.00 | Window Closed / Lapsed |