US4024233A
Expired / Lapsed
US
⏱️ 0.0 years remaining
99M-technetium labeled macroaggregated human serum albumin pharmaceutical
Assignee: United States Department of Energy
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Filing: 1974-07-24
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Granted: 1977-05-17
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Expires: 1994-07-24
Abstract
Abstract A reagent comprising macroaggregated human serum albumin having dispersed therein particles of stannous tin and a method for instantly making a labeled pharmaceutical therefrom, are disclosed. The labeled pharmaceutical is utilized in organ imaging.
Inventors
- 👤 Harry S. Winchell
- 👤 Morton Barak
- 👤 Parmer Van Fleet, III
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:52
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1217; A61K51/02; A61K51/04; A61K51/08; A61K51/081; A61K51/1241; A61K51/1255; A61K2123/00; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2989
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
60 words
A stable reagent suitable for the preparation of a 99m-technetium labeled pharmaceutical for scintigraphic organ imaging by the addition of a solution of 99m-technetium pertechnetate comprising an aqueous suspension of macroaggregated human serum albumin sized for such imaging having distributed throughout particles of colloidal stannous tin, said particles of colloidal stannous tin being entrapped throughout each particle of said macroaggregates.
Claim 2
Dependent Claim
60 words
A stable reagent suitable for the preparation of a 99m-technetium labeled pharmaceutical for scintigraphic organ imaging by the addition of a solution of 99m-technetium pertechnetate comprising an aqueous suspension of macroaggregated human serum albumin sized for such imaging having distributed throughout particles of colloidal stannous tin, said particles of colloidal stannous tin being entrapped throughout each particle of said macroaggregates.
Claim 3
Dependent Claim
92 words
A method of preparing the reagent of claim 1 which comprises: a. heating a dispersion of human serum albumin in physiological saline to coagulate said albumin into a macroaggregate; b. mixing with said warm dispersion a colloid of hydrolyzed stannous chloride in pyrogen free water; c. cooling said mixture thereby entrapping particles of colloidal stannous tin throughout each particle of said macroaggregate; d. filtering the resulting dispersion to remove therefrom substantially all particles larger than 100 microns; and e. washing said dispersion to remove therefrom substantially all particles smaller than 10 microns.
Claim 4
Dependent Claim
46 words
A 99m-technetium labeled pharmaceutical for scintigraphic organ imaging comprising a physiological suspension of macroaggregated human serum albumin sized for said imaging having distributed throughout particles of colloidal stannous tin, said tin particles being entrapped throughout each particle of said macroaggregate, said macroaggregates being labeled with 99m-technetium.
Claim 5
Dependent Claim
46 words
A 99m-technetium labeled pharmaceutical for scintigraphic organ imaging comprising a physiological suspension of macroaggregated human serum albumin sized for said imaging having distributed throughout particles of colloidal stannous tin, said tin particles being entrapped throughout each particle of said macroaggregate, said macroaggregates being labeled with 99m-technetium.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-16 | 1980-11-15 | 1981-05-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-16 | 1984-11-15 | 1985-05-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-16 | 1988-11-15 | 1989-05-17 | $7700.00 | Window Closed / Lapsed |