US4022900A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Compositions containing 1,2,3,4-tetrahydroisoquinolines used as hypotensive agents
Assignee: Marion Laboratories Inc
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Filing: 1972-12-11
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Granted: 1977-05-10
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Expires: 1992-12-11
Abstract
Abstract Disclosed are 5,6,7 or 8-nuclear substituted benzamido-1,2,3,4-tetrahydroisoquinolines of the formula ##STR1## in which R is a phenyl containing one to three hydroxyl, nitro, halo, lower alkyl or lower alkoxy groups, and R 1 is hydrogen or a lower alkyl. The compounds lower blood pressure in animals.
Inventors
- 👤 Ian William Mathison
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 13:44
CPC Classifications
C; C07; C07C; C07C63/00; C07C63/68; C07C63/70; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61K31/472; C07C205/00; C07C205/49; C07C205/57; C07C65/00; C07C65/21; C07D; C07D217/00; C07D217/02; C07D217/04
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
61 words
A method of lowering blood pressure in a hypertensive animal which comprises administering to said animal, in an amount effective to lower the blood pressure, a compound of the formula ##STR6## or a nontoxic acid addition salt thereof, wherein R is a nuclear substituted phenyl group containing one to three lower alkoxy groups and R 1 represents a lower alkyl group.
Claim 2
Independent Claim
61 words
A method of lowering blood pressure in a hypertensive animal which comprises administering to said animal, in an amount effective to lower the blood pressure, a compound of the formula ##STR6## or a nontoxic acid addition salt thereof, wherein R is a nuclear substituted phenyl group containing one to three lower alkoxy groups and R 1 represents a lower alkyl group.
Claim 3
Dependent Claim
12 words
The method of claim 1 in which each lower alkoxy is methoxy.
Claim 4
Dependent Claim
11 words
The method of claim 2 in which R 1 is methyl.
Claim 5
Dependent Claim
11 words
The method of claim 2 in which R 1 is propyl.
Claim 6
Independent Claim
28 words
A method of lowering blood pressure in a hypertensive animal which comprises administering to said animal, in an amount effective to lower the blood pressure, the compound 5-(3,4,5-trimethoxybenzamido)-2-methyl-1,2,3,4-tetrahydroisoquinoline.
Claim 7
Independent Claim
28 words
A method of lowering blood pressure in a hypertensive animal which comprises administering to said animal, in an amount effective to lower the blood pressure, the compound 5-(3,4,5-trimethoxybenzamido)-2-methyl-1,2,3,4-tetrahydroisoquinoline.
Claim 8
Dependent Claim
55 words
An anti-hypertensive pharmaceutical composition in unit dosage form comprising about 0.02 to 400 mg of a compound of the formula ##STR7## or a nontoxic acid addition salt thereof, wherein R is a nuclear-substituted phenyl group containing one to three lower alkoxy groups and R 1 is lower alkyl group, in admixture with a pharmaceutical carrier.
Claim 9
Dependent Claim
55 words
An anti-hypertensive pharmaceutical composition in unit dosage form comprising about 0.02 to 400 mg of a compound of the formula ##STR7## or a nontoxic acid addition salt thereof, wherein R is a nuclear-substituted phenyl group containing one to three lower alkoxy groups and R 1 is lower alkyl group, in admixture with a pharmaceutical carrier.
Claim 10
Dependent Claim
15 words
An anti-hypertensive composition according to claim 6 in which each alkoxy is a methoxy group.
Claim 11
Dependent Claim
13 words
An anti-hypertensive composition according to claim 7 in which R 1 is methyl.
Claim 12
Dependent Claim
13 words
An anti-hypertensive composition according to claim 7 in which R 1 is propyl.
Claim 13
Dependent Claim
22 words
An anti-hypertensive pharmaceutical composition in unit dosage form comprising about 0.02 to 400 mg of 5(3,4,5-trimethoxybenzamido)-2-methyl-1,2,3,4-tetrahydroisoquinoline in admixture with a pharmaceutical carrier.
Claim 14
Dependent Claim
22 words
An anti-hypertensive pharmaceutical composition in unit dosage form comprising about 0.02 to 400 mg of 5(3,4,5-trimethoxybenzamido)-2-methyl-1,2,3,4-tetrahydroisoquinoline in admixture with a pharmaceutical carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-09 | 1980-11-08 | 1981-05-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-09 | 1984-11-08 | 1985-05-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-09 | 1988-11-08 | 1989-05-10 | $7700.00 | Window Closed / Lapsed |