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US4022833A
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N,N'-bridged-bis[2-alkyl-2-hydroxyethylamines]
Assignee: STWB Inc
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Filing: 1975-06-02
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Granted: 1977-05-10
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Expires: 1995-06-02
Abstract
Abstract N,N'-Bridged-bis[(O and/or N-substituted)-2-alkyl-2-hydroxyethylamines] of the formula ##STR1## are prepared by condensing an epoxide of the formula ##STR2## and a diamine of the formula R'NH-X-NHR'. The products and dicarbanilates, acid-addition salts, N,N'-dioxides and N,N'-diammonium quaternary salts derived therefrom have antibacterial activity in vitro and are useful as antibacterial agents.
Inventors
- 👤 Guy D. Diana
- 👤 Royal A. Cutler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 05:42
CPC Classifications
C; C07; C07C; C07C291/00; C07C291/02; C07C291/04
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
130 words
N,N'-(X)-bis of the formula ##STR14## wherein: R is alkyl of three to fifteen carbon atoms or cycloalkyl of four to seven ring carbon atoms; R' is hydrogen or atertiary alkyl of one to four carbon atoms; X is X'-Y-X", wherein X' and X" are alkylene of one to four carbon atoms with bonds to Y and to the nitrogen atoms at the same or different carbon atoms and Y is cycloslkylene of four to seven ring carbon atoms with bonds to X' and X" at the same or different carbon atoms; the sum of the number of carbon atoms of R and X is at least nine; Z is hydrogen; or an acid-addition salt thereof; or when R' is atertiary alkyl of one to four carbon atoms, an N,N'-dioxide thereof.
Claim 2
Dependent Claim
130 words
N,N'-(X)-bis of the formula ##STR14## wherein: R is alkyl of three to fifteen carbon atoms or cycloalkyl of four to seven ring carbon atoms; R' is hydrogen or atertiary alkyl of one to four carbon atoms; X is X'-Y-X", wherein X' and X" are alkylene of one to four carbon atoms with bonds to Y and to the nitrogen atoms at the same or different carbon atoms and Y is cycloslkylene of four to seven ring carbon atoms with bonds to X' and X" at the same or different carbon atoms; the sum of the number of carbon atoms of R and X is at least nine; Z is hydrogen; or an acid-addition salt thereof; or when R' is atertiary alkyl of one to four carbon atoms, an N,N'-dioxide thereof.
Claim 3
Dependent Claim
91 words
N,N'-(X)-bis wherein: R is alkyl of three to fifteen carbon atoms; R' is hydrogen or atertiary alkyl of one to four carbon atoms; X is X'-Y-X", wherein X' and X" are alkylene of one to four carbon atoms with bonds to Y and to the nitrogen atoms at the same or different carbon atoms and Y is cycloalkylene of four to seven ring carbon atoms with the bonds to X' and X" at the same or different carbon atoms; Z is nydrogen; or an acid-addition salt thereof according to claim 1.
Claim 4
Dependent Claim
29 words
N,N'-(x)-bis[N-(R')-2-(R)-2-(ZO)-ethylamine] wherein: R is alkyl of three to fifteen carbon atoms; R' is hydrogen; X is 1,4-cyclohexylenebismethyl; Z is hydrogen; or an acid-addition salt thereof according to claim 2.
Claim 5
Dependent Claim
5 words
N,N'-(1,4-cyclohexylenebismethyl)-bis[2-hydroxyoctylamine] according to claim 3.
Claim 6
Dependent Claim
5 words
N,N'-(1,4-cyclohexylenebismethyl)-bis[2-hydroxydecylamine] according to claim 3.
Claim 7
Dependent Claim
5 words
N,N'-(cis-1,4-cyclohexylenebismethyl)-bis[2-hydroxydecylamine] according to claim 3.
Claim 8
Dependent Claim
5 words
N,N'-(trans-1,4-cyclohexylenebismethyl)-bis[2-hydroxydecylamine] according to claim 3.
Claim 9
Dependent Claim
5 words
N,N'-(1,4-cyclohexylenebismethyl)-bis[2-hydroxydodecylamine] according to claim 3.
Claim 10
Dependent Claim
29 words
N,N'-(X)-bis[N-(R')-2-(R)-2-(ZO)-ethylamine] wherein: R is alkyl of three to fifteen carbon atoms; R' is methyl; X is 1,4-cyclohexylenebismethyl; Z is hydrogen; or an acid-addition salt thereof according to claim 2.
Claim 11
Dependent Claim
5 words
N,N'-(1,4-cyclohexylenebismethyl)-bis[N-methyl-2-hydroxydecylamine] according to claim 9.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-09 | 1980-11-08 | 1981-05-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-09 | 1984-11-08 | 1985-05-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-09 | 1988-11-08 | 1989-05-10 | $7700.00 | Window Closed / Lapsed |