Patent US4022760A successfully refreshed from Google Patents.
US4022760A
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US
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Tripeptides and methods for their production
Assignee: Parke Davis and Co LLC
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Filing: 1976-01-19
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Granted: 1977-05-10
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Expires: 1996-01-19
Abstract
Abstract New tripeptides having the formula A-R 1 -Tyr(benzyl)-Thr(benzyl)-R 2 wherein A is t-butoxycarbonyl or cyclohexylcarbonyl, R 1 is Trp, His(benzyl), Cys(benzyl) or Pro and R 2 is lower alkoxy, hydrazino, amino, lower alkylamino, di(lower alkyl)amino, benzylamino, allylamino, (diethoxyphosphinyl)methylamino, 2-(diethoxyphosphinyl)ethylamino or 2-[[(phenylmethyl)amino]sulfonyl]ethylamino, methods for their production, and the use of said tripeptides as luteinizing hormone releasing factor antagonists.
Inventors
- 👤 Francis John Tinney
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 18:26
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0821
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
40 words
A tripeptide represented by the formula A-R.sub.1 -Tyr(benzyl)-Thr(benzyl)-R.sub.2 wherein A is t-butoxycarbonyl or cyclohexylcarbonyl, R 1 is Trp, His(benzyl), Cys(benzyl) or Pro and R 2 is lower alkoxy, hydrazino, amino, lower alkylamino, di(lower alkyl)amino, benzylamino, allylamino, (diethoxyphosphinyl)methylamino, 2-(diethoxyphosphinyl)ethylamino or 2-[[(phenylmethyl)amino]sulfonyl]ethylamino.
Claim 2
Dependent Claim
40 words
A tripeptide represented by the formula A-R.sub.1 -Tyr(benzyl)-Thr(benzyl)-R.sub.2 wherein A is t-butoxycarbonyl or cyclohexylcarbonyl, R 1 is Trp, His(benzyl), Cys(benzyl) or Pro and R 2 is lower alkoxy, hydrazino, amino, lower alkylamino, di(lower alkyl)amino, benzylamino, allylamino, (diethoxyphosphinyl)methylamino, 2-(diethoxyphosphinyl)ethylamino or 2-[[(phenylmethyl)amino]sulfonyl]ethylamino.
Claim 3
Dependent Claim
12 words
The compound of claim 1 having the name N.sup.α-t-butoxycarbonyl-N im -benzyl-L-histidyl-O-benzyl-L-tyrosyl-O-benzyl-L-threonine N-ethylamide.
References Cited (Backward Citations)
US3725380A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-09 | 1980-11-08 | 1981-05-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-09 | 1984-11-08 | 1985-05-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-09 | 1988-11-08 | 1989-05-10 | $7700.00 | Window Closed / Lapsed |