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US4021544A
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Complement inhibitors
Assignee: Wyeth Holdings LLC
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Filing: 1976-07-12
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Granted: 1977-05-03
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Expires: 1996-07-12
Abstract
Abstract Sulfated oligosaccharides of the maltose series useful as complement inhibitors.
Inventors
- 👤 Vijay Gopalan Nair
- 👤 Joseph Peter Joseph
- 👤 Seymour Bernstein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 19:07
CPC Classifications
C; C07; C07H; C07H11/00; A; A61; A61K; A61K31/00; A61K31/70; A61P; A61P29/00; A61P37/00; A61P37/02; A61P37/06; A61P37/08; A61P7/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
76 words
A method of inhibiting the complement system in a body fluid which comprises subjecting said body fluid to the action of an effective complement inhibiting amount of a compound selected from those of the formula: ##STR2## wherein M represents hydrogen or the salt of an alkali metal, alkaline earth metal, ammonia, triloweralkylamine (C 1 -C 6 ), piperidine, pyrazine, alkanolamine (C 1 -C 6 ); and cycloalkanolamine (C 3 -C 6 ); and n is 2-10.
Claim 2
Independent Claim
76 words
A method of inhibiting the complement system in a body fluid which comprises subjecting said body fluid to the action of an effective complement inhibiting amount of a compound selected from those of the formula: ##STR2## wherein M represents hydrogen or the salt of an alkali metal, alkaline earth metal, ammonia, triloweralkylamine (C 1 -C 6 ), piperidine, pyrazine, alkanolamine (C 1 -C 6 ); and cycloalkanolamine (C 3 -C 6 ); and n is 2-10.
Claim 3
Dependent Claim
21 words
A method according to claim 1 wherein n is 2-10 and M is selected from the group comprising trimethylamine and sodium.
Claim 4
Dependent Claim
13 words
A method according to claim 1 wherein the body fluid is blood serum.
Claim 5
Independent Claim
73 words
A method of inhibiting the complement system in a warm-blooded animal which comprises internally administering to said animal an effective complement inhibiting amount of a compound selected from those of the formula ##STR3## wherein M represents hydrogen or the salt of an alkali metal, alkaline earth metal, ammonia, triloweralkylamine (C 1 -C 6 ), piperidine, pyrazine, alkanolamine (C 1 -C 6 ); and cycloalkanolamine (C 3 -C 6 ); and n is 2-10.
Claim 6
Independent Claim
73 words
A method of inhibiting the complement system in a warm-blooded animal which comprises internally administering to said animal an effective complement inhibiting amount of a compound selected from those of the formula ##STR3## wherein M represents hydrogen or the salt of an alkali metal, alkaline earth metal, ammonia, triloweralkylamine (C 1 -C 6 ), piperidine, pyrazine, alkanolamine (C 1 -C 6 ); and cycloalkanolamine (C 3 -C 6 ); and n is 2-10.
Claim 7
Dependent Claim
12 words
A method according to claim 4 wherein the compound is administered intra-articularly.
Claim 8
Dependent Claim
21 words
A method according to claim 4 wherein n is 2-10 and M is selected from the group comprising trimethylamine and sodium.
References Cited (Backward Citations)
US3911915A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-02 | 1980-11-01 | 1981-05-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-02 | 1984-11-01 | 1985-05-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-02 | 1988-11-01 | 1989-05-03 | $7700.00 | Window Closed / Lapsed |