US4021340A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Blood separating composition
Assignee: Corning Glass Works
•
Filing: 1975-11-28
•
Granted: 1977-05-03
•
Expires: 1995-11-28
Abstract
Abstract Gel-like compositions useful for separating and partitioning whole blood into serum and clot portions. The composition comprises a polybutene liquid polymer having an inert high surface area inorganic filler dispersed therein, the filler being present in an amount sufficient to impart to the composition a specific gravity ranging from about 1.030 to about 1.090 and a viscosity ranging from about 200,000 to about 850,000 centistokes. When centrifuged in the presence of whole blood, the composition forms a chemical and physical barrier between the serum and clot portions.
Inventors
- 👤 Anthony R. Zine, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 03:21
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/491
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
119 words
A method of separating a sample of whole blood into serum and clot portions comprising the steps of: 1. placing into a container adapted to be centrifuged a quantity of whole blood and a quantity of thixotropic, water-insoluble composition comprising a polybutene liquid polymer having an inert inorganic filler dispersed therein in a quantity sufficient to provide a specific gravity in the composition of 1.030 to about 1.090, a thixotropic index ranging from about 2 to 6, and a viscosity ranging from about 200,000 to 850,000 centistokes; and 2. centrifuging the container under conditions sufficient to cause the blood to separate into serum and clot portions with the composition migrating to a position intermediate the serum and clot portions.
Claim 2
Independent Claim
119 words
A method of separating a sample of whole blood into serum and clot portions comprising the steps of: 1. placing into a container adapted to be centrifuged a quantity of whole blood and a quantity of thixotropic, water-insoluble composition comprising a polybutene liquid polymer having an inert inorganic filler dispersed therein in a quantity sufficient to provide a specific gravity in the composition of 1.030 to about 1.090, a thixotropic index ranging from about 2 to 6, and a viscosity ranging from about 200,000 to 850,000 centistokes; and 2. centrifuging the container under conditions sufficient to cause the blood to separate into serum and clot portions with the composition migrating to a position intermediate the serum and clot portions.
Claim 3
Dependent Claim
17 words
The method of claim 1 wherein the specific gravity of the composition ranges from 1.037 to 1.050.
Claim 4
Dependent Claim
25 words
The method of claim 1 wherein the inert filler comprises finely divided silica particles having a surface area of at least 50 m 2 /g.
Claim 5
Dependent Claim
46 words
The method of claim 1 wherein the composition comprises about 34 to 41 parts by weight silica particles, about 100 parts by weight polybutene liquid having a molecular weight ranging from about 610 to 920, and has a specific gravity ranging from about 1.037 to 1.050.
Claim 6
Dependent Claim
29 words
The method of claim 1 wherein the composition is contained in an individual test tube, the tube being stoppered and capable of receiving about 10 ml. of whole blood.
Claim 7
Dependent Claim
29 words
The method of claim 5 wherein the test tube has a volume of about 15 ml. and the amount of composition contained therein is about 1 to 4 grams.
Claim 8
Dependent Claim
65 words
A thixotropic composition useful for separating whole blood into serum and clot portions and comprising a polybutene liquid polymer having dispersed therein an essentially inert inorganic filler in a quantity sufficient to impart to the total composition a specific gravity ranging from about 1.030 to 1.090, a thixotropic index ranging from about 2 to 6, and a viscosity ranging from about 200,000 to 850,000 centistokes.
Claim 9
Dependent Claim
65 words
A thixotropic composition useful for separating whole blood into serum and clot portions and comprising a polybutene liquid polymer having dispersed therein an essentially inert inorganic filler in a quantity sufficient to impart to the total composition a specific gravity ranging from about 1.030 to 1.090, a thixotropic index ranging from about 2 to 6, and a viscosity ranging from about 200,000 to 850,000 centistokes.
Claim 10
Dependent Claim
25 words
The composition of claim 7 wherein the inert filler comprises finely divided silica particles having a surface area of at least 50 m 2 /g.
Claim 11
Dependent Claim
15 words
The composition of claim 7 wherein the specific gravity ranges from about 1.037 to 1.050.
References Cited (Backward Citations)
US3210273A
Cited
US3500603A
Cited
US3574135A
Cited
US3663726A
Cited
US3780935A
Cited
US3920557A
Cited
US3920549A
Cited
US3977982A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-02 | 1980-11-01 | 1981-05-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-02 | 1984-11-01 | 1985-05-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-02 | 1988-11-01 | 1989-05-03 | $7700.00 | Window Closed / Lapsed |