Water-soluble pharmaceutical complexes of partricin or an alkyl ester thereof with sodium desoxycholate or sodium dehydrocholate

Claim 1

A water-soluble pharmaceutical complex, comprising an antibiotic selected from the group consisting of partricin, partricin methyl ester and partricin ethyl ester and a complex-forming compound selected from the group consisting of sodium desoxycholate and sodium dehydrocholate, wherein the weight ratio of the antibiotic to the complex-forming compound is about 1:1, said partricin having an Rf value of about 0.50 on silica gel using butanol-ethanol-acetone-25% ammonium hydroxide in a ratio of 2:5:1:3 as eluent, ultraviolet absorption maxima at 410, 379, 359 and 341 mμ in ethanol at a concentration of about 0.01 mg/ml, infrared absorption maxima at 3355, 1704, 1596, 1175, 1070, 995 and 850 cm - 1 in nujol, and an elemental analysis of C = 62.8%, H = 7.9%, N= 3.2% and O =25.2% said complex having an ultraviolet absorption spectrum and Rf value equal to the ultraviolet absorption spectrum and Rf value of the antibiotic alone.