US4017603A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Water-soluble pharmaceutical complexes of partricin or an alkyl ester thereof with sodium desoxycholate or sodium dehydrocholate
Assignee: Prodotti Antibiotici SpA
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Filing: 1975-08-29
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Granted: 1977-04-12
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Expires: 1995-08-29
Abstract
Abstract The present invention provides a water-soluble pharmaceutical complex, comprising the antibiotic partricin and/or an alkyl ester thereof and sodium desoxycholate and/or sodium dehydrocholate.
Inventors
- 👤 Rodolfo Ferrari
- 👤 Ernani Dell'Acqua
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 06:43
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08; C07J; C07J9/00; C07J9/005
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
148 words
A water-soluble pharmaceutical complex, comprising an antibiotic selected from the group consisting of partricin, partricin methyl ester and partricin ethyl ester and a complex-forming compound selected from the group consisting of sodium desoxycholate and sodium dehydrocholate, wherein the weight ratio of the antibiotic to the complex-forming compound is about 1:1, said partricin having an Rf value of about 0.50 on silica gel using butanol-ethanol-acetone-25% ammonium hydroxide in a ratio of 2:5:1:3 as eluent, ultraviolet absorption maxima at 410, 379, 359 and 341 mμ in ethanol at a concentration of about 0.01 mg/ml, infrared absorption maxima at 3355, 1704, 1596, 1175, 1070, 995 and 850 cm - 1 in nujol, and an elemental analysis of C = 62.8%, H = 7.9%, N= 3.2% and O =25.2% said complex having an ultraviolet absorption spectrum and Rf value equal to the ultraviolet absorption spectrum and Rf value of the antibiotic alone.
Claim 2
Dependent Claim
148 words
A water-soluble pharmaceutical complex, comprising an antibiotic selected from the group consisting of partricin, partricin methyl ester and partricin ethyl ester and a complex-forming compound selected from the group consisting of sodium desoxycholate and sodium dehydrocholate, wherein the weight ratio of the antibiotic to the complex-forming compound is about 1:1, said partricin having an Rf value of about 0.50 on silica gel using butanol-ethanol-acetone-25% ammonium hydroxide in a ratio of 2:5:1:3 as eluent, ultraviolet absorption maxima at 410, 379, 359 and 341 mμ in ethanol at a concentration of about 0.01 mg/ml, infrared absorption maxima at 3355, 1704, 1596, 1175, 1070, 995 and 850 cm - 1 in nujol, and an elemental analysis of C = 62.8%, H = 7.9%, N= 3.2% and O =25.2% said complex having an ultraviolet absorption spectrum and Rf value equal to the ultraviolet absorption spectrum and Rf value of the antibiotic alone.
Claim 3
Dependent Claim
14 words
A complex according to claim 1, wherein the antibiotic is the partricin methyl ester.
Claim 4
Dependent Claim
14 words
A complex according to claim 1, wherein the antibiotic is the partricin ethyl ester.
Claim 5
Dependent Claim
28 words
A pharmaceutical composition, comprising a complex according to claim 1, in admixture with a member selected from the group consisting of solid and liquid pharmaceutical diluents and carriers.
References Cited (Backward Citations)
US3773925A
Cited
US3780173A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-04-11 | 1980-10-11 | 1981-04-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-04-11 | 1984-10-11 | 1985-04-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-04-11 | 1988-10-11 | 1989-04-12 | $7700.00 | Window Closed / Lapsed |