Abstract 3-Indolyl pyridyl ketones of the general formula: <IMAGE> and pharmaceutically acceptable acid addition salts thereof wherein R1 represents A STRAIGHT- OR BRANCHED-CHAIN SATURATED OR UNSATURATED ALKYL GROUP HAVING NOT MORE THAN 6 CARBON ATOMS, A BENZYL GROUP OPTIONALLY SUBSTITUTED IN THE AROMATIC PORTION BY A CHLORINE ATOM OR A METHOXY GROUP OR <IMAGE> wherein A represents an alkylene chain of from 2 to 6 carbon atoms and R4 and R5, which may be the same or different, are each an alkyl group having from 1 to 5 carbon atoms, or R4 and R5 are joined together to form with the nitrogen atom a piperidino, pyrrolidino or morpholino group, R2 represents A BRANCHED-OR STRAIGHT-CHAIN ALKYL GROUP HAVING FROM 1 TO 4 CARBON ATOMS, A PHENYL GROUP OPTIONALLY SUBSTITUTED BY A FLUORINE, CHLORINE, OR BROMINE ATOM OR A METHOXY OR CYCLOHEXYL GROUP; AND R3 represents A 2-PYRIDYL, 3-PYRIDYL OR 4-PYRIDYL GROUP.
Inventors
👤 Marcel Descamps
👤 Henri Inion
Bibliographic Details
Application Number—
JurisdictionUS
Data Sourcegoogle_patents
Last Synchronized2026-11-04 07:09
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/06
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
121 words
An indole derivative represented by the formula: ##STR7##and pharmaceutically acceptable acid addition salts thereof, wherein R 1 represents ##STR8##wherein A represents an alkylene chain of from 2 to 6 carbon atoms and R 4 and R 5 , which may be the same or different, are each an alkyl group having from 1 to 5 carbon atoms, or R 4 and R 5 are joined together to form with the nitrogen atom a piperidino, pyrrolidino or morpholino group, R 2 represents a branched-or straight-chain alkyl group having from 1 to 4 carbon atoms, a phenyl group optionally substituted by a fluorine, chlorine, or bromine atom, or a methoxy or cyclohexyl group; and R 3 represents a 2-pyridyl, 3-pyridyl or 4-pyridyl group.
Claim 2
Dependent Claim
121 words
An indole derivative represented by the formula: ##STR7##and pharmaceutically acceptable acid addition salts thereof, wherein R 1 represents ##STR8##wherein A represents an alkylene chain of from 2 to 6 carbon atoms and R 4 and R 5 , which may be the same or different, are each an alkyl group having from 1 to 5 carbon atoms, or R 4 and R 5 are joined together to form with the nitrogen atom a piperidino, pyrrolidino or morpholino group, R 2 represents a branched-or straight-chain alkyl group having from 1 to 4 carbon atoms, a phenyl group optionally substituted by a fluorine, chlorine, or bromine atom, or a methoxy or cyclohexyl group; and R 3 represents a 2-pyridyl, 3-pyridyl or 4-pyridyl group.
Claim 3
Dependent Claim
9 words
(1-γ-piperidinopropyl-2-isopropyl-3-indolyl)(2-pyridyl) ketone and pharmaceutically acceptable acid addition salts thereof.
Claim 4
Dependent Claim
9 words
(1-γ-piperidinopropyl-2-isopropyl-3-indolyl)(2-pyridyl) ketone and pharmaceutically acceptable acid addition salts thereof.
Claim 5
Dependent Claim
9 words
[1-β-dimethylaminoethyl-2-(4-methoxy-phenyl)-3-indolyl](3-pyridyl) ketone and pharmaceutically acceptable acid addition salts thereof.
Claim 6
Dependent Claim
9 words
[1-β-dimethylaminoethyl-2-(4-methoxy-phenyl)-3-indolyl](3-pyridyl) ketone and pharmaceutically acceptable acid addition salts thereof.