Patent US4011215A successfully refreshed from Google Patents.
US4011215A
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3-Chloroalkylcarbamoyloxymethyl-7-[2-(fur-2-yl)-2-methoxyiminoacetamido]ceph-3-em-4-carboxylic acids and physiologically acceptable salts or oxides thereof
Assignee: Glaxo Laboratories Ltd
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Filing: 1975-08-01
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Granted: 1977-03-08
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Expires: 1995-08-01
Abstract
Abstract Cephalosporin antibiotics in which the 7β-acylamido group is syn 2-furyl-2-methoxyiminoacetamido and in which the 3-position substituent is a chloroalkylcarbamoyloxymethyl group exhibit high antibacterial activity against a broad range of gram positive and gram negative organisms, particularly high stability to β-lactamases produced by various organisms, and stability in vivo. The compounds are syn isomers or exist as mixtures of syn and anti isomers containing at least 90% of the syn isomer.
Inventors
- 👤 Martin C. Cook
- 👤 Gordon I. Gregory
- 👤 Janice Bradshaw
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 19:53
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; C07D501/24; C07D501/26; C07D501/34
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
37 words
A compound selected from the group consisting of a cephalosporin antibiotic of the formula ##STR8## wherein R s represents a C 1 -C 4 alkyl group substituted by chlorine, and a physiologically acceptable salt or oxide thereof.
Claim 2
Dependent Claim
37 words
A compound selected from the group consisting of a cephalosporin antibiotic of the formula ##STR8## wherein R s represents a C 1 -C 4 alkyl group substituted by chlorine, and a physiologically acceptable salt or oxide thereof.
Claim 3
Dependent Claim
11 words
The compound of claim 1 which is (6R,7R)-3-(2-chloroethylcarbamoyloxymethyl)-7-[2-(fur-2-yl)-2-methoxyiminoacetamido]ceph-3-em-4-carboxylic acid (syn isomer).
Claim 4
Dependent Claim
11 words
The compound of claim 1 which is sodium (6R,7R)-3-(2-chloroethylcarbamoyloxymethyl)-7-[2-(fur-2-yl)-2-methoxyiminoacetamido]3-em-4-carboxylate (syn isomer).
Claim 5
Dependent Claim
11 words
The compound of claim 1 which is (6R,7R)-3-chloromethylcarbamoyloxymethyl-7-[2-(fur-2-yl)-2-methoxyiminoacetamido]ceph-3-em-4-carboxylic acid (syn isomer).
Claim 6
Dependent Claim
10 words
The compoundof claim 1 which is (6R,7R)-3-(3-chloropropylcarbamoyloxymethyl)-7-[2-(fur-2-yl)-2-methoxyiminoacetamido]ceph-3-em-4-carboxylic acid (syn isomer).
Claim 7
Dependent Claim
11 words
The compound of claim 1 which is sodium (6R,7R)-3-(3-chloropropylcarbamoyloxymethyl)-7-[2-(fur-2-yl)-2-methoxyiminoacetamido]ceph-3-em-4-carboxylate (syn isomer).
References Cited (Backward Citations)
US3573294A
Cited
US3946219A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-03-07 | 1980-09-06 | 1981-03-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-03-07 | 1984-09-06 | 1985-03-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-03-07 | 1988-09-06 | 1989-03-08 | $7700.00 | Window Closed / Lapsed |