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Patent US4009265A successfully refreshed from Google Patents.
US4009265A
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Methods and formulations for the treatment of obesity
Assignee: WILLIAM HARVEY STIFTUNG fur FORSCHUNG und AUSBILDUNG
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Filing: 1973-03-05
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Granted: 1977-02-22
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Expires: 1993-03-05
Abstract
Abstract It has been discovered that the unfavorable effects observed in weight reduction treatments based on severe dietary restriction (less than 600 Kcals/day) or total fasting (as regards fat, carbohydrates and aminoacids) are avoided by the administration of aminoacids and carbohydrates in critical but much lower amounts than has been believed to be necessary. Nitrogen loss with aminoacid intake between about 15 and 30 g per day is affected by carbohydrate intake. Nitrogen balance is maintained and ketosis and water retention are controlled when the daily intake includes, in addition to necessary minerals and vitamins, at least 15 g of aminoacids in the proportions required by man, and from 15 to 75 g, preferably 30 to 45 g, of carbohydrates, with a total caloric value of from 160 to about 600 Kcals, preferably less than 400 Kcals, very desirably less than 360 Kcals, and optimally in the range of from 180 to 360 Kcals. Formulations are described in which the least amount containing the minimum daily requirement of minerals also contains at least 15 g of aminoacids (as a monomeric aminoacid mixture or as natural protein) and from 15 to 75 g, preferably from 30 to 45 g, of carbohydrates, together with optional other constituents.
Inventors
- 👤 Alan Norman Howard
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 02:11
CPC Classifications
A; A23; A23L; A23L33/00; A23L33/10; A23L33/17; A23L33/18; A23L33/115; A23L33/30; A23L33/40; A23V; A23V2002/00
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
217 words
A method for treating obesity in which an individual ingests on a daily basis a dietary formulation which comprises: a. all the minerals required by man; b. proteinaceous material selected from at least one member of the class consisting of: i. a mixture of monomeric L-aminoacids, and ii. natural proteins, and iii. natural proteins reinforced with at least one monomeric L-aminoacid; and c. digestible carbohydrate; characterized in that the smallest amont of the dietary formulation containing at least the minimum daily requirements of each of the minerals required by man, including at least 800 mg calcium, 800 mg phosphorous, 140 μg iodine, 10 mg iron and 350 mg magnesium, also contains: A. at least 15 g of said proteinaceous material which must include at least the minimum daily requirements for man of all the essential L-aminoacids requied by man; and B. from 15 to 75 g of said carbohydrate, and further characterized in that the total caloric value of said smallest amount of dietary formulation is in the range of from 160 to 600 Kcals. and wherein the amount of said dietary formulation ingested daily by said individual is such that it provides said individual with: at least 15 g of said proteinaceous material; from 15 to 75 g of said carbohydrate; and 160 to 600 Kcals.
Claim 2
Independent Claim
217 words
A method for treating obesity in which an individual ingests on a daily basis a dietary formulation which comprises: a. all the minerals required by man; b. proteinaceous material selected from at least one member of the class consisting of: i. a mixture of monomeric L-aminoacids, and ii. natural proteins, and iii. natural proteins reinforced with at least one monomeric L-aminoacid; and c. digestible carbohydrate; characterized in that the smallest amont of the dietary formulation containing at least the minimum daily requirements of each of the minerals required by man, including at least 800 mg calcium, 800 mg phosphorous, 140 μg iodine, 10 mg iron and 350 mg magnesium, also contains: A. at least 15 g of said proteinaceous material which must include at least the minimum daily requirements for man of all the essential L-aminoacids requied by man; and B. from 15 to 75 g of said carbohydrate, and further characterized in that the total caloric value of said smallest amount of dietary formulation is in the range of from 160 to 600 Kcals. and wherein the amount of said dietary formulation ingested daily by said individual is such that it provides said individual with: at least 15 g of said proteinaceous material; from 15 to 75 g of said carbohydrate; and 160 to 600 Kcals.
Claim 3
Dependent Claim
44 words
A method according to claim 1 wherein the caloric value of said smallest amount of the formulation is not greater than 400 Kcals and wherein the amount of the formulation ingested daily by said individual provides said individual with no greater than 400 Kcals.
Claim 4
Dependent Claim
44 words
A method according to claim 2 wherein the caloric value of said smallest amount of the formulation is not greater than 360 Kcals and wherein the amount of the formulation ingested daily by said individual provides said individual with no greater than 360 Kcals.
Claim 5
Dependent Claim
49 words
A method according to claim 1, in which the said smallest amount of the formulation includes at least the minimum daily requirements of each of the vitamins required by man in substantially the relative proportions required by man and at least the minimum daily fatty acid requirements of man.
Claim 6
Independent Claim
198 words
A method for the treatment of obesity in man, which comprises the steps of giving the overweight patient a daily diet consisting essentially of: a. at least the minimum daily requirement of all the minerals required by man, including at least 800 mg calcium, 800 mg phosphorous, 140 μg iodine, 10 mg iron and 350 mg magnesium; b. proteinaceous material selected from at least one member of the class consisting of: i. a mixture of monomeric L-aminoacids, and ii. natural proteins, and iii. natural proteins reinforced with at least one monomeric L-aminoacid; c. digestible carbohydrate; d. at least the minimum daily requirement of all the vitamins required by man; and e. sufficient fat, oil or other source of essential fatty acid to supply the patient's minimum fatty acid requirements; said method being characterized in that the amount of proteinaceous material given daily is at least 15 g and contains at least the minimum daily requirements for man of all the essential L-aminoacids required by man, and the amount of carbohydrate given daily is from 15 to 75 g, and that the total caloric value of the daily diet is in the range of from 160 to 600 Kcals.
Claim 7
Independent Claim
198 words
A method for the treatment of obesity in man, which comprises the steps of giving the overweight patient a daily diet consisting essentially of: a. at least the minimum daily requirement of all the minerals required by man, including at least 800 mg calcium, 800 mg phosphorous, 140 μg iodine, 10 mg iron and 350 mg magnesium; b. proteinaceous material selected from at least one member of the class consisting of: i. a mixture of monomeric L-aminoacids, and ii. natural proteins, and iii. natural proteins reinforced with at least one monomeric L-aminoacid; c. digestible carbohydrate; d. at least the minimum daily requirement of all the vitamins required by man; and e. sufficient fat, oil or other source of essential fatty acid to supply the patient's minimum fatty acid requirements; said method being characterized in that the amount of proteinaceous material given daily is at least 15 g and contains at least the minimum daily requirements for man of all the essential L-aminoacids required by man, and the amount of carbohydrate given daily is from 15 to 75 g, and that the total caloric value of the daily diet is in the range of from 160 to 600 Kcals.
Claim 8
Dependent Claim
22 words
A method according to claim 5, in which the total caloric value of the daily diet is not greater than 400 Kcals.
Claim 9
Dependent Claim
20 words
A method according to claim 5, in which the minerals are given in substantially the relative proportions required by man.
Claim 10
Dependent Claim
33 words
A method according to claim 5, in which the ratio by weight of the proteinaceous material to the digestible carbohydrate in the daily diet is in the range of from 1:1 to 1:5.
Claim 11
Dependent Claim
39 words
A method according to claim 5, in which the proteinaceous material in the diet is or includes natural protein derived from at least one member of the class consisting of egg albumin, milk, soya beans, peanuts, fish and plasma.
Claim 12
Dependent Claim
54 words
A method according to claim 5, in which the proteinaceous material in the diet is or includes natural protein derived from at least one member of the class consisting of milk, soya beans, peanuts, fish and plasma, reinforced with at least one monomeric aminoacid to adjust its aminoacid profile to that required by man.
Claim 13
Dependent Claim
65 words
A method according to claim 5, in which the proteinaceous material is or includes a mixture of aminoacids produced by taking a protein hydrolysate (produced by subjecting a protein to hydrolysis by an acid or a proteolase), analysing its aminoacid profile and adjusting same to the optimum profile either by adding the required quantities of aminoacids or by passing the hydrolysate through suitable exchange resins.
Claim 14
Dependent Claim
17 words
A method according to claim 5, in which the carbohydrate in the diet comprises a partially-hydrolyzed polysaccharide.
Claim 15
Dependent Claim
47 words
A method according to claim 1 wherein the caloric value of said smallest amount of the formulation is in the range of from 180 to 240 Kcals and wherein the amount of the formulation ingested daily by said individual provides said individual with 180 to 240 Kcals.
Claim 16
Dependent Claim
22 words
A method according to claim 5 in which the total caloric value of the daily diet is not greater than 360 Kcals.
Claim 17
Dependent Claim
25 words
A method according to claim 5 in which the total caloric value of the daily diet is in the range of 180 to 240 Kcals.
Claim 18
Independent Claim
186 words
A method for treating obesity in which an individual ingests a daily diet consisting essentially of: a. at least the minimum daily requirement of all the minerals required by man, including at least 800 mg calcium, 800 mg phosphorous, 140 μg iodine, 10 mg iron and 350 mg magnesium; b. proteinaceous material selected from at least one member of the class consisting of: i. a mixture of monomeric L-amino-acids, and ii. natural proteins, and iii. natural proteins reinforced with at least one monomeric L-amino-acid; and c. digestible carbohydrate; said method being characterized: in that the amount of proteinaceous material ingested daily is at least 15 g and contains at least the minimum daily requirements for man of all the essential L-aminoacids required by man; in that the amount of carbohydrate ingested daily is from 15 to 75 g; in that the total caloric value of the daily diet is in the range of from 180 to 600 Kcals; and in that the ratio of weight of the proteinaceous material to the digestible carbohydrate in the daily diet is in the range of from 1:1 to 1:5.
Claim 19
Independent Claim
186 words
A method for treating obesity in which an individual ingests a daily diet consisting essentially of: a. at least the minimum daily requirement of all the minerals required by man, including at least 800 mg calcium, 800 mg phosphorous, 140 μg iodine, 10 mg iron and 350 mg magnesium; b. proteinaceous material selected from at least one member of the class consisting of: i. a mixture of monomeric L-amino-acids, and ii. natural proteins, and iii. natural proteins reinforced with at least one monomeric L-amino-acid; and c. digestible carbohydrate; said method being characterized: in that the amount of proteinaceous material ingested daily is at least 15 g and contains at least the minimum daily requirements for man of all the essential L-aminoacids required by man; in that the amount of carbohydrate ingested daily is from 15 to 75 g; in that the total caloric value of the daily diet is in the range of from 180 to 600 Kcals; and in that the ratio of weight of the proteinaceous material to the digestible carbohydrate in the daily diet is in the range of from 1:1 to 1:5.
Claim 20
Dependent Claim
19 words
A method according to claim 16 in which said ratio is in the range of from 1:2 to 1:4.
Claim 21
Dependent Claim
22 words
A method according to claim 17 in which the total caloric value of the daily diet is not greater than 360 Kcals.
Claim 22
Dependent Claim
79 words
A method according to claim 17 wherein said minerals, said proteinaceous material and said cabohydrate are ingested in the form of a dietary formulation characterized in that the smallest amount of said dietary formulation which contains at least said minimum daily requirements of each of the minerals required by man, also contains 15 to 25 g of said proteinaceous material, 30 to 45 g of said carbohydrate, and has a total caloric value of not greater than 360 Kcals.
Claim 23
Dependent Claim
109 words
A method according to claim 16 wherein said minerals, said proteinaceous material and said carbohydrate are ingested in the form of a dietary formulation characterized in that the smallest amount of said dietary formulation which contains at least said minimum daily requirements of each of the minerals required by man, also contains at least 15 g of said proteinaceous material, 15 to 75 g of said carbohydrate, has a total caloric value of 180 to 600 Kcals and the amounts of proteinaceous material and carbohydrates in said formulation are such that the weight ratio of the proteinaceous material to the carbohydrate is in the range of 1:1 to 1:5.
References Cited (Backward Citations)
US3849554A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-02-22 | 1980-08-23 | 1981-02-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-02-22 | 1984-08-23 | 1985-02-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-02-22 | 1988-08-23 | 1989-02-22 | $7700.00 | Window Closed / Lapsed |