Patent US4009264A successfully refreshed from Google Patents.
US4009264A
Expired / Lapsed
US
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Complexes of polysaccharides or derivatives thereof with reduced glutathione and process for preparing said complexes
Assignee: Meito Sangyo KK
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Filing: 1975-04-01
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Granted: 1977-02-22
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Expires: 1995-04-01
Abstract
Abstract A complex of a polysaccharide or its derivative with reduced glutathione having in its infrared absorption spectrum no absorption peak at about 2500 cm - 1 which appears in the infrared absorption spectrum of the reduced glutathione. The complex is prepared by reacting the polysaccharide or its derivative activated with an activating agent selected from cyanogen halides, organic cyanic acid esters and alkyl esters of halogenocarbonic acids, with the reduced glutathione at a pH of less than 7. The complex is especially useful for stabilizing thiol groups.
Inventors
- 👤 Akihiro Mizutani
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 16:20
CPC Classifications
C; C08; C08B; C08B31/00; C08B15/00; C08B33/00; C08B35/00; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0021
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
57 words
A complex of a polysaccharide with reduced glutathione, said complex having an infrared absorption spectrum with no absorption peak at about 2500 cm.sup. -1 which peak appears in the infrared absorption spectrum of said reduced glutathione; said polysaccharide being a member selected from the group consisting of dextran, hydrogenated dextran, hydroxyalkyl dextran, carboxyalkyl dextran and dextran sulfate.
Claim 2
Dependent Claim
57 words
A complex of a polysaccharide with reduced glutathione, said complex having an infrared absorption spectrum with no absorption peak at about 2500 cm.sup. -1 which peak appears in the infrared absorption spectrum of said reduced glutathione; said polysaccharide being a member selected from the group consisting of dextran, hydrogenated dextran, hydroxyalkyl dextran, carboxyalkyl dextran and dextran sulfate.
Claim 3
Dependent Claim
48 words
The complex of claim 17 which has a residual ratio of its active SH group of at least 50% when it is incubated at 40° C. for 6 hours in a sodium phosphate buffer (0.1 M,pH 8.0) in the presence of FeCl 3 (1.2 × 10.sup. -5 M).
Claim 4
Dependent Claim
87 words
A pharmaceutical composition for protection against radiation damage, which comprises a complex of a polysaccharide with reduced glutathione, said complex having an infrared absorption spectrum without an absorption peak at about 2500 cm.sup. -1 , which peak appears in the infrared absorption spectrum of said reduced glutathione; said polysaccharide being a member selected from the group consisting of dextran, hydrogenated dextran, hydroxyalkyl dextran, carboxyalkyl dextran and dextran sulfate; and a pharmaceutically acceptable carrier or diluent; said complex being present in an amount effective to prevent radiation damage.
Claim 5
Dependent Claim
87 words
A pharmaceutical composition for protection against radiation damage, which comprises a complex of a polysaccharide with reduced glutathione, said complex having an infrared absorption spectrum without an absorption peak at about 2500 cm.sup. -1 , which peak appears in the infrared absorption spectrum of said reduced glutathione; said polysaccharide being a member selected from the group consisting of dextran, hydrogenated dextran, hydroxyalkyl dextran, carboxyalkyl dextran and dextran sulfate; and a pharmaceutically acceptable carrier or diluent; said complex being present in an amount effective to prevent radiation damage.
Claim 6
Dependent Claim
87 words
A pharmaceutical composition for protection against liver damage, which comprises a complex of a polysaccharide with reduced glutathione, said complex having an infrared absorption spectrum without an absorption peak at about 2500 cm.sup. -1 , which peak appears in the infrared absorption spectrum of said reduced glutathione; said polysaccharide being a member selected from the group consisting of dextran, hydrogenated dextran, hydroxyalkyl dextran, carboxyalkyl dextran and dextran sulfate; and a pharmaceutically acceptable carrier or diluent; said complex being present in an amount effective to prevent liver damage.
Claim 7
Dependent Claim
87 words
A pharmaceutical composition for protection against liver damage, which comprises a complex of a polysaccharide with reduced glutathione, said complex having an infrared absorption spectrum without an absorption peak at about 2500 cm.sup. -1 , which peak appears in the infrared absorption spectrum of said reduced glutathione; said polysaccharide being a member selected from the group consisting of dextran, hydrogenated dextran, hydroxyalkyl dextran, carboxyalkyl dextran and dextran sulfate; and a pharmaceutically acceptable carrier or diluent; said complex being present in an amount effective to prevent liver damage.
References Cited (Backward Citations)
GB1223281A
Cited
US3645852A
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US3619371A
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US3788948A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-02-22 | 1980-08-23 | 1981-02-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-02-22 | 1984-08-23 | 1985-02-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-02-22 | 1988-08-23 | 1989-02-22 | $7700.00 | Window Closed / Lapsed |