Patent US4007181A successfully refreshed from Google Patents.
US4007181A
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Adamantyl containing guanidines
Assignee: Pharmacia and Upjohn Co
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Filing: 1974-02-11
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Granted: 1977-02-08
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Expires: 1994-02-11
Abstract
Abstract Novel compounds of FIG. 1, pharmaceutical compositions thereof, and systemic means of administration for anti-arrhythmic and diuretic uses are disclosed: ##STR1##
Inventors
- 👤 Donald W. DuCharme
- 👤 Louis L. Skaletzky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 11:40
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/16; C07D295/20; C07D295/215
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
97 words
A compound of the formula ##STR142## wherein R 1 and R 2 are the same or different and when R 1 and R 2 are the same they are adamantyl and when R 1 and R 2 are different, R 1 is adamantyl and R 2 is cycloalkyl of five to seven carbon atoms, inclusive; R 3 and R 4 taken together with the nitrogen atom to which they are attached form a saturated heterocyclic ring ##STR143## wherein ##STR144## is pyrrolidino, piperidino, hexamethyleneimino, piperazino, N-alkylpiperazino wherein alkyl is one to three carbon atoms, inclusive, morpholino or thiomorpholino.
Claim 2
Dependent Claim
97 words
A compound of the formula ##STR142## wherein R 1 and R 2 are the same or different and when R 1 and R 2 are the same they are adamantyl and when R 1 and R 2 are different, R 1 is adamantyl and R 2 is cycloalkyl of five to seven carbon atoms, inclusive; R 3 and R 4 taken together with the nitrogen atom to which they are attached form a saturated heterocyclic ring ##STR143## wherein ##STR144## is pyrrolidino, piperidino, hexamethyleneimino, piperazino, N-alkylpiperazino wherein alkyl is one to three carbon atoms, inclusive, morpholino or thiomorpholino.
Claim 3
Dependent Claim
14 words
Compounds in accordance with claim 1 wherein R 1 and R 2 are adamantyl.
Claim 4
Dependent Claim
5 words
N-1-adamantyl-N'-cyclohexyl-4-morpholinecarboxamidine according to claim 1.
Claim 5
Dependent Claim
6 words
N-1-adamantyl-N'-cyclohexyl-4-morpholinecarboxamidine hydrochloride according to claim 1.
Claim 6
Dependent Claim
5 words
N,N'-di-1-adamantyl-4-morpholinecarboxamidine according to claim 1.
Claim 7
Dependent Claim
6 words
N,N-di-1-adamantyl-4-morpholinecarboxamidine hydrochloride according to claim 1.
Claim 8
Dependent Claim
5 words
N,N-di-2-adamantyl-4-morpholinecarboxamidine according to claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-02-08 | 1980-08-09 | 1981-02-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-02-08 | 1984-08-09 | 1985-02-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-02-08 | 1988-08-09 | 1989-02-08 | $7700.00 | Window Closed / Lapsed |