Patent US4007174A successfully refreshed from Google Patents.
US4007174A
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Cephalosporin compounds
Assignee: Glaxo Laboratories Ltd
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Filing: 1974-07-01
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Granted: 1977-02-08
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Expires: 1994-07-01
Abstract
Abstract Novel syn-7β-(2-aryl-2-hydroxyiminoacetamido)ceph-3-em-4- carboxylic acids carrying a 7α-lower alkoxy substituent, particularly a 7α-methoxy group, which are broad spectrum antibiotics exhibiting low serum binding are described.
Inventors
- 👤 Brian Laundon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 15:38
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; C07D307/00; C07D307/02; C07D307/34; C07D307/38; C07D307/54; C07D333/00; C07D333/02; C07D333/04; C07D333/06; C07D333/24; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
91 words
A compound selected from the group consisting of a cephalosporin antibiotic of the formula: ##STR18## wherein R is phenyl, thienyl or furyl; R 1 is C 1 -C 4 alkoxy; and P is a group -CH 2 Y is -SR 6 ; in which R 6 is lower alkyl, lower alkanoyl, thiadiazolyl, 5-methyl-1,3,4-thiadizol-2-yl, diazolyl, triazolyl, tetrazolyl, 1-methyl-tetrazol-5-yl, thiazolyl, thiatriazolyl, oxazolyl, oxadiazolyl, benzimidazoyl and benzoxazolyl; which is the syn isomer or a mixture of syn and anti isomers containing at least 75% of the syn isomer and a physiologically acceptable salt thereof.
Claim 2
Dependent Claim
91 words
A compound selected from the group consisting of a cephalosporin antibiotic of the formula: ##STR18## wherein R is phenyl, thienyl or furyl; R 1 is C 1 -C 4 alkoxy; and P is a group -CH 2 Y is -SR 6 ; in which R 6 is lower alkyl, lower alkanoyl, thiadiazolyl, 5-methyl-1,3,4-thiadizol-2-yl, diazolyl, triazolyl, tetrazolyl, 1-methyl-tetrazol-5-yl, thiazolyl, thiatriazolyl, oxazolyl, oxadiazolyl, benzimidazoyl and benzoxazolyl; which is the syn isomer or a mixture of syn and anti isomers containing at least 75% of the syn isomer and a physiologically acceptable salt thereof.
Claim 3
Dependent Claim
12 words
The compound of claim 1 which is (6R, 7S)-7-[2-hydroxyimino-2-(thien-2-yl)-acetamido]-7-methoxy-3-(1-methyltetrazol-5-ylthiomethyl)ceph-3-em-4-carboxylic acid (syn isomer).
Claim 4
Dependent Claim
22 words
The compound of claim 1 which is a mixture of syn and anti isomers containing at least 90% of the syn isomer.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-02-08 | 1980-08-09 | 1981-02-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-02-08 | 1984-08-09 | 1985-02-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-02-08 | 1988-08-09 | 1989-02-08 | $7700.00 | Window Closed / Lapsed |