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US4005207A
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Synergistic therapeutic composition for the treatment of mycobacterioses
Assignee: Saarstickstoff-Fatol GmbH
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Filing: 1974-08-07
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Granted: 1977-01-25
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Expires: 1994-08-07
Abstract
Abstract The specification relates to an oral composition for the treatment of mycobacterioses, such as the treatment of leprosy and tuberculosis, containing an effective amount of isonicotinic acid hydrazide (international non-proprietary name isoniazid, designated herein as INH), an effective amount of 2-propyl-thioisonicotinic acid amide (prothionamide designated herein as PTH) and/or 2-ethyl-thioisonicotinic acid amide (ethionamide designated herein as ETH) and an effective amount of a sulfone and/or a sulfonamide with sustained activity. Suitable sulfones and sulfonamides with sustained activity, among others, are 4,4'-diaminodiphenyl-sulfone designated herein as DDS, sulfamethoxypyridazine and the like, as well as combinations of sulfones with sulfonamides, such as trimethoprimsulfonamides.
Inventors
- 👤 Enno Freerksen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 15:01
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/63
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
32 words
A synergistic therapeutic composition for the treatment of mycobacterioses in mammals comprising about 83 mg isonicotinic acid hydrazide, about 84 mg 2-propyl-thioisonicotinic acid amide, and about 33 mg 4,4'-diaminodiphenyl-sulfone per dosage unit.
Claim 2
Dependent Claim
32 words
A synergistic therapeutic composition for the treatment of mycobacterioses in mammals comprising about 83 mg isonicotinic acid hydrazide, about 84 mg 2-propyl-thioisonicotinic acid amide, and about 33 mg 4,4'-diaminodiphenyl-sulfone per dosage unit.
Claim 3
Dependent Claim
32 words
A synergistic therapeutic composition for the treatment of mycobacterioses in mammals comprising about 175 mg isonicotinic acid hydrazide, about 175 mg 2-propyl-thioisonicotinic acid amide, and about 50 mg 4,4'-diaminodiphenyl-sulfone per dosage unit.
Claim 4
Dependent Claim
32 words
A synergistic therapeutic composition for the treatment of mycobacterioses in mammals comprising about 175 mg isonicotinic acid hydrazide, about 175 mg 2-propyl-thioisonicotinic acid amide, and about 50 mg 4,4'-diaminodiphenyl-sulfone per dosage unit.
Claim 5
Dependent Claim
40 words
A synergistic therapeutic composition for the treatment of mycobacterioses in mammals comprising about 5 to 10 mg isonicotinic acid hydrazide, about 5 to 10 mg 2-propyl-thioisonicotinic acid amide, and about 1 to 2 mg 4,4'-diaminodiphenyl-sulfone per kilogram of body weight.
Claim 6
Dependent Claim
40 words
A synergistic therapeutic composition for the treatment of mycobacterioses in mammals comprising about 5 to 10 mg isonicotinic acid hydrazide, about 5 to 10 mg 2-propyl-thioisonicotinic acid amide, and about 1 to 2 mg 4,4'-diaminodiphenyl-sulfone per kilogram of body weight.
Claim 7
Dependent Claim
30 words
The composition according to claim 3 comprising about 5 mg isonicotinic acid hydrazide, about 5 mg 2-propyl-thioisonicotinic acid amide and about 2 mg 4,4'-diaminodiphenyl sulfone per kilogram of body weight.
Claim 8
Dependent Claim
40 words
A process for treating mycobacterioses in mammals which comprises administering orally to mammals having mycobacterial diseases a synergistic composition comprising about 83 mg isonicotinic acid hydrazide, about 84 mg 2-propyl-thioisonicotinic acid amide, and about 33 mg 4,4'-diaminodiphenyl-sulfone per dosage unit.
Claim 9
Dependent Claim
40 words
A process for treating mycobacterioses in mammals which comprises administering orally to mammals having mycobacterial diseases a synergistic composition comprising about 83 mg isonicotinic acid hydrazide, about 84 mg 2-propyl-thioisonicotinic acid amide, and about 33 mg 4,4'-diaminodiphenyl-sulfone per dosage unit.
Claim 10
Dependent Claim
40 words
A process for treating mycobacterioses in mammals which comprises administering orally to mammals having mycobacterial diseases a synergistic composition comprising about 175 mg isonicotinic acid hydrazide, about 175 mg 2-propyl-thioisonicotinic acid amide, and about 50 mg 4,4'-diaminodiphenyl-sulfone per dosage unit.
Claim 11
Dependent Claim
40 words
A process for treating mycobacterioses in mammals which comprises administering orally to mammals having mycobacterial diseases a synergistic composition comprising about 175 mg isonicotinic acid hydrazide, about 175 mg 2-propyl-thioisonicotinic acid amide, and about 50 mg 4,4'-diaminodiphenyl-sulfone per dosage unit.
Claim 12
Dependent Claim
48 words
A process for treating mycobacterioses in mammals which comprises administering orally to mammals having mycobacterial diseases a synergistic composition comprising about 5 to 10 mg isonicotinic acid hydrazide, about 5 to 10 mg 2-propyl-thioisonicotinic acid amide, and about 1 to 2 mg 4,4'-diaminodiphenyl-sulfone per kilogram of body weight.
Claim 13
Dependent Claim
48 words
A process for treating mycobacterioses in mammals which comprises administering orally to mammals having mycobacterial diseases a synergistic composition comprising about 5 to 10 mg isonicotinic acid hydrazide, about 5 to 10 mg 2-propyl-thioisonicotinic acid amide, and about 1 to 2 mg 4,4'-diaminodiphenyl-sulfone per kilogram of body weight.
Claim 14
Dependent Claim
35 words
A process according to claim 7 in which the synergistic composition comprises about 5 mg isonicotinic acid hydrazide, about 5 mg 2-propyl-thioisonicotinic acid amide, and about 2 mg 4,4'-diaminodiphenyl sulfone per kilogram of body weight.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-01-25 | 1980-07-26 | 1981-01-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-01-25 | 1984-07-26 | 1985-01-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-01-25 | 1988-07-26 | 1989-01-25 | $7700.00 | Window Closed / Lapsed |