Patent US4001237A successfully refreshed from Google Patents.
US4001237A
Expired / Lapsed
US
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Oxazole, isoxazole, thiazole and isothiazole amides
Assignee: Bristol Myers Co
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Filing: 1976-02-18
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Granted: 1977-01-04
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Expires: 1996-02-18
Abstract
Abstract Compounds having the formula ##STR1## wherein Z is a substituted or unsubstituted oxazole, is isoxazole, thiazole or isothiazole group are potent antihypertensive drugs which have generally less α-adrenergic blocking activity than does 2-[4-(2-furoyl)-piperazin-1-yl]-4-amino-6,7-dimethoxy-quinazoline which is a known potent antihypertensive drug.
Inventors
- 👤 Richard Anthony Partyka
- 👤 Ronnie Ray Crenshaw
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 15:19
CPC Classifications
C; C07; C07D; C07D413/00; C07D413/14; C07D239/00; C07D239/70; C07D239/72; C07D239/95; C07D417/00; C07D417/14
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
73 words
A compound having the formula: wherein Z is either the radical ##STR19## in which X is either oxygen or sulfur and R 1 and R 2 may be the same or different and are selected from the group consisting of hydrogen, (lower)alkyl having from 1 to 6 carbon atoms, (lower)alkoxy having from 1 to 6 carbon atoms and (lower)alkylthio having from 1 to 6 carbon atoms and pharmaceutically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
73 words
A compound having the formula: wherein Z is either the radical ##STR19## in which X is either oxygen or sulfur and R 1 and R 2 may be the same or different and are selected from the group consisting of hydrogen, (lower)alkyl having from 1 to 6 carbon atoms, (lower)alkoxy having from 1 to 6 carbon atoms and (lower)alkylthio having from 1 to 6 carbon atoms and pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
66 words
A compound of claim 1 in which Z is the radical ##STR20## in which X is either oxygen or sulfur and R 1 and R 2 may be the same or different and are selected from the group consisting of hydrogen, (lower)alkyl having from 1 to 6 carbon atoms, (lower)alkoxy having from 1 to 6 carbon atoms and (lower)alkylthio having from 1 to 6 carbon atoms.
Claim 4
Dependent Claim
10 words
A compound of claim 2 in which X is oxygen.
Claim 5
Dependent Claim
10 words
A compound of claim 2 in which X is sulfur.
Claim 6
Dependent Claim
66 words
A compound of claim 1 in which Z is the radical ##STR21## in which X is either oxygen or sulfur and R 1 and R 2 may be the same or different and are selected from the group consisting of hydrogen, (lower)alkyl having from 1 to 6 carbon atoms, (lower)alkoxy having from 1 to 6 carbon atoms and (lower)alkylthio having from 1 to 6 carbon atoms.
Claim 7
Dependent Claim
10 words
A compound of claim 5 in which X is oxygen.
Claim 8
Dependent Claim
10 words
A compound of claim 5 in which X is sulfur.
Claim 9
Dependent Claim
11 words
A compound of claim 1 being the compound 4-amino-6,7-dimethoxy-2-[4-(oxazole-4-carbonyl)piperazin-1-yl] quinazoline hydrochloride.
Claim 10
Dependent Claim
10 words
A compound of claim 1 being the compound 4-amino-6,7-dimethoxy-2-[4-(isothiazole-4-carbonyl)piperazin-1-yl]quinazoline hydrochloride.
Claim 11
Dependent Claim
11 words
A compound of claim 1 being the compound 4-amino-6,7-dimethoxy-2-[4-(2-methylthiazole-4-carbonyl)piperazin-1-yl] quinazoline hydrochloride.
Claim 12
Dependent Claim
10 words
A compound of claim 1 being the compound 4-amino-6,7-dimethoxy-2-[4-(2-methylthiazole-5-carbonyl)piperazin-1-yl]quinazoline hydrochloride.
Claim 13
Dependent Claim
10 words
A compound of claim 1 being the compound 4-amino-6,7-dimethoxy-2-[4-(5-methylisoxazole-3-carbonyl)piperazin-1-yl]quinazoline hydrochloride.
References Cited (Backward Citations)
US3511836A
Cited
US3935213A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-01-04 | 1980-07-05 | 1981-01-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-01-04 | 1984-07-05 | 1985-01-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-01-04 | 1988-07-05 | 1989-01-04 | $7700.00 | Window Closed / Lapsed |