Patent US4000254A successfully refreshed from Google Patents.
US4000254A
Expired / Lapsed
US
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Fungimycin compositions
Assignee: London International Us Holdings Inc
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Filing: 1975-03-21
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Granted: 1976-12-28
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Expires: 1995-03-21
Abstract
Abstract A method of increasing the overall effectiveness, including stability and gastrointestinal tolerability, of a polyenic macrolide selected from the class consisting of candicidin, fungimycin, hamycin and mediocidin is described which comprises orally administering the polyenic macrolide with an absorbent material. Compositions containing a polyenic macrolide and a suitable absorbent material preferably in beadlet form are described for use in treating various conditions including prostate hypertrophy, hypercholesterolemia and acne.
Inventors
- 👤 Harry W. Gordon
- 👤 Carl P. Schaffner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 05:19
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K9/00; A61K9/14; A61K9/141; A61K9/143; A61K9/48; A61K9/4841; A61K9/485; A61K9/50; A61K9/5073; A61K9/5078; E; E02; E02F; E02F9/00; E02F9/20; E02F9/22; E02F9/2264; E02F9/2275
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
68 words
A composition comprising a capsule containing a multiplicity of beadlets said beadlets together comprising (1) about 25 mg to about 100 mg of fungimycin, and (2) an absorbent material which binds with said fungimycin in a substantially acidic pH environment and loses its affinity for said fungimycin in a substantially neutral pH environment, the ratio of said fungimycin to said absorbent material being about 1:2 to about 1:8.
Claim 2
Dependent Claim
68 words
A composition comprising a capsule containing a multiplicity of beadlets said beadlets together comprising (1) about 25 mg to about 100 mg of fungimycin, and (2) an absorbent material which binds with said fungimycin in a substantially acidic pH environment and loses its affinity for said fungimycin in a substantially neutral pH environment, the ratio of said fungimycin to said absorbent material being about 1:2 to about 1:8.
Claim 3
Dependent Claim
55 words
A solid composition according to claim 1 wherein said absorbent material is selected from the class consisting of a non-toxic inorganic material whose cation portion is selected from the class consisting of a divalent and trivalent metal and whose anion portion is selected from the class consisting of a carbonate, phosphate, silicate, sulfate and hydroxide.
Claim 4
Dependent Claim
22 words
A solid composition according to claim 2 wherein said cation is selected from the class consisting of calcium, magnesium, iron and aluminum.
Claim 5
Dependent Claim
16 words
A composition according to claim 1 wherein said fungimycin is coated with a sustained release coating.
Claim 6
Dependent Claim
18 words
A solid composition according to claim 4 wherein said beadlets are contained in a hard gelatin shell capsule.
Claim 7
Dependent Claim
24 words
A solid composition according to claim 5 which includes an acidic material for maintaining the pH of said composition between about 6.5 and 7.5.
Claim 8
Dependent Claim
59 words
A formulation comprising a hard shell capsule containing a multiplicity of beadlets, said beadlets together comprising (1) about 25 to about 100 mg of fungimycin and (2) about 50 to about 400 mg of calcium carbonate, the ratio of fungimycin to calcium carbonate being no greater than about 1:2, said formulation having a pH between about 6.5 and 7.5.
Claim 9
Dependent Claim
59 words
A formulation comprising a hard shell capsule containing a multiplicity of beadlets, said beadlets together comprising (1) about 25 to about 100 mg of fungimycin and (2) about 50 to about 400 mg of calcium carbonate, the ratio of fungimycin to calcium carbonate being no greater than about 1:2, said formulation having a pH between about 6.5 and 7.5.
Claim 10
Dependent Claim
17 words
A solid formulation according to claim 7 wherein said fungimycin is coated with a sustained release coating.
Claim 11
Dependent Claim
16 words
A solid composition according to claim 8 wherein said sustained release coating is an enteric coating.
Claim 12
Dependent Claim
11 words
A composition according to claim 7 which includes a potassium phosphate.
References Cited (Backward Citations)
US2956925A
Cited
US3432593A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-12-28 | 1980-06-28 | 1980-12-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-12-28 | 1984-06-28 | 1984-12-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-12-28 | 1988-06-28 | 1988-12-28 | $7700.00 | Window Closed / Lapsed |