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US3996162A
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Analytical sorbent and method of use
Assignee: Nuclear Medical Laboratories Inc
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Filing: 1974-03-01
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Granted: 1976-12-07
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Expires: 1994-03-01
Abstract
Abstract An analytic sorbent material is prepared by wetting a particulate inorganic crystalline lattice material, such as magnesium silicate with an aqueous fluid such as a barbital buffer solution or distilled water, and thereafter heating the wetted sorbent until its sorption capacity stabilizes.
Inventors
- 👤 Mary S. McCall
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 11:31
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/02; B01J20/10; B01J20/0203; B01J20/024; B01J20/0248; B01J20/0274; B01J20/0277; B01J20/0281; B01J20/0292; B01J20/04; B01J20/041; B01J20/043; B01J20/045; B01J20/048; B01J20/30; B01J20/3078; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/74; G01N33/78; Y; Y10; Y10S; Y10S206/00; Y10S206/828; Y10S502/00; Y10S502/519; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375; Y10T436/255
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
129 words
A method of preparing an analytical sorbent for an in vitro diagnostic test which has a stabilized sorbent capacity for endogenous material found in a body fluid selected from the group consisting of protein-type constituents and metals comprising: a. wetting a particulate inorganic crystalline lattice material with an aqueous buffer solution, said particulate inorganic crystalline lattice material being selected from the group consisting of carbonates, phosphates, oxides, hydroxides, silicates, aluminates, and sulfates of the metallic elements in Groups IA, IIA, IIIA, IIB and VIII of the Periodic Table and mixed salts thereof; and b. heating the resulting dispersion at a temperature of from about 25° C to the boiling point of said aqueous buffer solution for a sufficient time to cause the sorbent capacity of said material to stabilize.
Claim 2
Independent Claim
129 words
A method of preparing an analytical sorbent for an in vitro diagnostic test which has a stabilized sorbent capacity for endogenous material found in a body fluid selected from the group consisting of protein-type constituents and metals comprising: a. wetting a particulate inorganic crystalline lattice material with an aqueous buffer solution, said particulate inorganic crystalline lattice material being selected from the group consisting of carbonates, phosphates, oxides, hydroxides, silicates, aluminates, and sulfates of the metallic elements in Groups IA, IIA, IIIA, IIB and VIII of the Periodic Table and mixed salts thereof; and b. heating the resulting dispersion at a temperature of from about 25° C to the boiling point of said aqueous buffer solution for a sufficient time to cause the sorbent capacity of said material to stabilize.
Claim 3
Dependent Claim
37 words
The method of claim 1 wherein said aqueous buffer solution contains buffers selected from the group consisting of barbital buffer, tris (hydroxymethyl) amino methane buffer, tris (hydroxymethyl) aminomethane maleate buffer, sodium phosphate buffer, and potassium phosphate buffer.
Claim 4
Dependent Claim
10 words
The analytical sorbent produced by the method of claim 2.
Claim 5
Independent Claim
131 words
A method of preparing an analytical sorbent for an in vitro diagnostic test which has a stabilized sorbent capacity for endogenous material found in a body fluid selected from the group consisting of protein-type constituents and metals comprising: a. wetting a particulate inorganic crystalline lattice material with a standard aqueous saline solution, said particulate inorganic crystalline lattice material being selected from the group consisting of carbonates, phosphates, oxides, hydroxides, silicates, aluminates, and sulfates of the metallic elements in Groups IA, IIA, IIIA, IIB and VIII of the Periodic Table and mixed salts thereof; and b. heating the resulting dispersion at a temperature of from about 25° C to the boiling point of said standard aqueous saline solution for a sufficient time to cause the sorbent capacity of said material to stabilize.
Claim 6
Independent Claim
131 words
A method of preparing an analytical sorbent for an in vitro diagnostic test which has a stabilized sorbent capacity for endogenous material found in a body fluid selected from the group consisting of protein-type constituents and metals comprising: a. wetting a particulate inorganic crystalline lattice material with a standard aqueous saline solution, said particulate inorganic crystalline lattice material being selected from the group consisting of carbonates, phosphates, oxides, hydroxides, silicates, aluminates, and sulfates of the metallic elements in Groups IA, IIA, IIIA, IIB and VIII of the Periodic Table and mixed salts thereof; and b. heating the resulting dispersion at a temperature of from about 25° C to the boiling point of said standard aqueous saline solution for a sufficient time to cause the sorbent capacity of said material to stabilize.
Claim 7
Dependent Claim
10 words
The analytical sorbent produced by the method of claim 4.
Claim 8
Independent Claim
168 words
A method for preparing an analytical mixture containing a sorbent, for use in vitro diagnostic test which has a stabilized sorbent capacity for endogenous material found in a body fluid selected from the group consisting of protein-type constituents and metals, said mixture including an aqueous medium consisting essentially of an aqueous buffer solution and a particulate inorganic crystalline sorbent material selected from the group consisting of carbonates, phosphates, oxides, hydroxides, silicates, aluminates and sulfates of the metallic elements in Groups IA, IIA, IIIA, IIB and VIII of the Periodic Table and mixed salts thereof comprising: a. admixing said aqueous buffer solution and said sorbent and thereafter heating the mixture at a temperature in the range of from about 25° C to the boiling point of said aqueous buffer solution until the percent uptake of said analytical sorbent for said endogenous material will not vary greater than about ± 1.5 percent; and b. packaging the mixture of aqueous buffer solution and said stabilized sorbent material in a sealed container.
Claim 9
Independent Claim
168 words
A method for preparing an analytical mixture containing a sorbent, for use in vitro diagnostic test which has a stabilized sorbent capacity for endogenous material found in a body fluid selected from the group consisting of protein-type constituents and metals, said mixture including an aqueous medium consisting essentially of an aqueous buffer solution and a particulate inorganic crystalline sorbent material selected from the group consisting of carbonates, phosphates, oxides, hydroxides, silicates, aluminates and sulfates of the metallic elements in Groups IA, IIA, IIIA, IIB and VIII of the Periodic Table and mixed salts thereof comprising: a. admixing said aqueous buffer solution and said sorbent and thereafter heating the mixture at a temperature in the range of from about 25° C to the boiling point of said aqueous buffer solution until the percent uptake of said analytical sorbent for said endogenous material will not vary greater than about ± 1.5 percent; and b. packaging the mixture of aqueous buffer solution and said stabilized sorbent material in a sealed container.
Claim 10
Dependent Claim
10 words
The packaged mixture produced by the method of claim 6.
Claim 11
Dependent Claim
38 words
The method of claim 6 wherein said aqueous medium is water which contains a buffer material selected from group consisting of diethyl barbituic acid, tris (hydroxymethyl) amine methane, tris (hydroxymethyl) amino methane maleate, sodium phosphate, and potassium phosphate.
Claim 12
Dependent Claim
10 words
The packaged mixture produced by the method of claim 8.
Claim 13
Dependent Claim
154 words
A packaged analytical mixture within a sealed container comprising a sorbent for use in an in vitro diagnostic test which has a stabilized sorbent capacity for endogenous material found in a body fluid selected from the group consisting of protein type constituents and metals, said mixture including an aqueous buffer solution containing a particulate inorganic crystalline sorbent material selected from the group consisting of carbonates, phosphates, oxides, hydroxides, silicates, aluminates and sulfates of the metallic elements in Groups IA, IIA, IIIA, IIB and VIII of the Periodic Table and mixed salts thereof, said sorbent having been stabilized by a process comprising mixing said sorbent with an aqueous fluid consisting essentially of water and thereafter heating the resulting mixture at a temperature in the range of from about 25° C to the boiling point of said water for a sufficient time to cause the sorbent capacity of said material for said endogenous material to stabilize.
Claim 14
Dependent Claim
154 words
A packaged analytical mixture within a sealed container comprising a sorbent for use in an in vitro diagnostic test which has a stabilized sorbent capacity for endogenous material found in a body fluid selected from the group consisting of protein type constituents and metals, said mixture including an aqueous buffer solution containing a particulate inorganic crystalline sorbent material selected from the group consisting of carbonates, phosphates, oxides, hydroxides, silicates, aluminates and sulfates of the metallic elements in Groups IA, IIA, IIIA, IIB and VIII of the Periodic Table and mixed salts thereof, said sorbent having been stabilized by a process comprising mixing said sorbent with an aqueous fluid consisting essentially of water and thereafter heating the resulting mixture at a temperature in the range of from about 25° C to the boiling point of said water for a sufficient time to cause the sorbent capacity of said material for said endogenous material to stabilize.
Claim 15
Dependent Claim
38 words
The product of claim 10 wherein said aqueous buffer solution contains a buffer material selected from the group consisting of barbital buffer, tris(hydroxymethyl) amino methane buffer, tris(hydroxymethyl) amino methane maleate buffer, sodium phosphate buffer and potassium phosphate buffer.
Claim 16
Dependent Claim
99 words
A material for receiving and sorbing protein-type material in a clinical test procedure comprising an aqueous barbital buffer solution having dispersed therein a particulate inorganic crystalline lattice material selected from the group consisting of carbonates, phosphates, oxides, hydroxides, silicates, aluminates, and sulfates of the metallic elements in Groups IA, IIA, IIIA, IIB and VIII of the Periodic Table, and mixed salts thereof, which has been heated to a temperature of from about 25° C to the boiling point of said solution for a sufficient time to cause the sorbent capacity of said material to stabilize for said protein-type material.
Claim 17
Dependent Claim
99 words
A material for receiving and sorbing protein-type material in a clinical test procedure comprising an aqueous barbital buffer solution having dispersed therein a particulate inorganic crystalline lattice material selected from the group consisting of carbonates, phosphates, oxides, hydroxides, silicates, aluminates, and sulfates of the metallic elements in Groups IA, IIA, IIIA, IIB and VIII of the Periodic Table, and mixed salts thereof, which has been heated to a temperature of from about 25° C to the boiling point of said solution for a sufficient time to cause the sorbent capacity of said material to stabilize for said protein-type material.
Claim 18
Independent Claim
91 words
A method of treating a particulate inorganic crystalline lattice material selected from the group consisting of carbonates, phosphates, oxides, hydroxides, silicates, aluminates and sulfates of the metallic elements in Groups IA, IIA, IIIA, IIB and VIII of the Periodic Table, and mixed salts thereof, comprising wetting said material with an aqueous barbital buffer solution and thereafter heating the wetted material at a temperature of from about 25° C to the boiling point of said barbital buffer solution for a sufficient time to cause the sorbent capacity of said material to stabilize.
Claim 19
Independent Claim
91 words
A method of treating a particulate inorganic crystalline lattice material selected from the group consisting of carbonates, phosphates, oxides, hydroxides, silicates, aluminates and sulfates of the metallic elements in Groups IA, IIA, IIIA, IIB and VIII of the Periodic Table, and mixed salts thereof, comprising wetting said material with an aqueous barbital buffer solution and thereafter heating the wetted material at a temperature of from about 25° C to the boiling point of said barbital buffer solution for a sufficient time to cause the sorbent capacity of said material to stabilize.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-12-07 | 1980-06-07 | 1980-12-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-12-07 | 1984-06-07 | 1984-12-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-12-07 | 1988-06-07 | 1988-12-07 | $7700.00 | Window Closed / Lapsed |