Patent US3993757A successfully refreshed from Google Patents.
US3993757A
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Method of treating inflammation with morphanthridines
Assignee: Richardson Vicks Inc
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Filing: 1975-06-06
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Granted: 1976-11-23
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Expires: 1995-06-06
Abstract
Abstract The inventive method comprises administering a morphanthridine to an animal to effect the lowering of inflammation. Representative of the compounds that can be used in the method are trans-5-acetyl-2-bromo-5,6-dihydro-11-(3-dimethylaminopropylidene)-morphanthridine and trans-2-bromo-11-(3-dimethylaminopropylidene)-5,6-dihydro-5-propionylmorphanthridine.
Inventors
- 👤 Jules Freedman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 09:49
CPC Classifications
A; A61; A61K; A61K31/00; C; C07; C07D; C07D223/00; C07D223/14; C07D223/18; C07D223/20
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
150 words
A method of treating inflammation in animals which comprises the step of administering to an animal suffering from inflammation a safe and an anti-inflammatory effective amount of a trans isomer of a compound of the formula: ##SPC4## in which X is hydrogen, a halogen, trifluromethyl, a lower alkyl of 1 to 4 carbon atoms, or a lower alkoxy of 1 to 4 carbon atoms, R is hydrogen or an alkyl of 1 to 8 carbon atoms, R 1 is hydrogen or methyl, and R 2 and R 3 are selected from hydrogen, a lower alkyl of 1 to 4 carbon atoms, or a phenyl-lower alkyl of 7 to 13 carbon atoms, R 2 and R 3 may be joined together to form a heterocyclic amino group selected from the group consisting of morpholino, pyrrolidino, piperadino, N-lower alkyl piperazino, N-phenyl-lower alkyl piperazino or N-(hydroxy-lower alkyl)-piperazino; or a pharmaceutically acceptable salt thereof.
Claim 2
Independent Claim
150 words
A method of treating inflammation in animals which comprises the step of administering to an animal suffering from inflammation a safe and an anti-inflammatory effective amount of a trans isomer of a compound of the formula: ##SPC4## in which X is hydrogen, a halogen, trifluromethyl, a lower alkyl of 1 to 4 carbon atoms, or a lower alkoxy of 1 to 4 carbon atoms, R is hydrogen or an alkyl of 1 to 8 carbon atoms, R 1 is hydrogen or methyl, and R 2 and R 3 are selected from hydrogen, a lower alkyl of 1 to 4 carbon atoms, or a phenyl-lower alkyl of 7 to 13 carbon atoms, R 2 and R 3 may be joined together to form a heterocyclic amino group selected from the group consisting of morpholino, pyrrolidino, piperadino, N-lower alkyl piperazino, N-phenyl-lower alkyl piperazino or N-(hydroxy-lower alkyl)-piperazino; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
11 words
The method of claim 1 in which the compound is trans-5-acetyl-2-bromo-5,6-dihydro-11-(3-dimethylaminopropylidene)morphanthridine.
Claim 4
Dependent Claim
11 words
The method of claim 1 in which the compound is trans-2-bromo-11-(3-dimethylaminopropylidene)-5,6-dihydro-5-propionylmorphanthridine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-11-23 | 1980-05-24 | 1980-11-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-11-23 | 1984-05-24 | 1984-11-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-11-23 | 1988-05-24 | 1988-11-23 | $7700.00 | Window Closed / Lapsed |