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US3992175A
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US
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Method of and device for chromatographic separation of fluid mixtures into fractions
Assignee: Individual
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Filing: 1975-12-01
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Granted: 1976-11-16
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Expires: 1995-12-01
Abstract
Abstract A method of and a device for chromatographic separation of fluid mixtures into fractions by means of circulation of a continuously fed mixture in a system of several separating columns adapted for simultaneous passing of two independent fluid streams through separate series-connected parts of column system with a synchronized replacement of the inlet and outlet points of the fluid streams and inlet point of the mixture along the columns, comprising in accordance with the present invention, preliminary separation of the mixture by means of circulation in a system of at least three columns into two fractions being discharged from said system by two separate fluid streams; with subsequent passing of one or both streams containing the preliminarily separated fraction in the form of a mixture of substances through one or two additional separating columns respectively, wherein the fraction is separated into narrower fractions or individual components.
Inventors
- 👤 Toe Jokhannesovich Klementi
- 👤 Toivo Elmar-Jokhannesovich Kruusimagi
- 👤 Juri Arturovich Veisserik
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 13:58
CPC Classifications
G; G01; G01N; G01N30/00; G01N30/02; G01N30/26; G01N30/38; G01N30/46; G01N30/461; B; B01; B01D; B01D53/00; B01D53/02; B01D53/04; B01D53/0407; B01D53/0423; G01N30/44; G01N30/468; B01D15/00; B01D15/08; B01D15/10; B01D15/18; B01D15/1814; B01D15/1821; G01N30/04; G01N30/06; G01N30/08; G01N2030/085; G01N30/14; G01N2030/143
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
286 words
A method of chromatographic separation of fluid mixtures into fractions using four chromatographic columns connected into a circulation path adapted for simultaneous passing of two independent carrier gas streams through separated series parts of said path, in which method at each moment one column acts as enriching column, the second as stripping column, the third as regenerating column, the fourth acting as eluting column, the method comprising steps of: a. continuously introducing the mixture to be separated at constant flow rate into a pipe connecting the stripping column to the enriching column; b. recovering at the outlet of the enriching column a preselected fraction of the mixture containing at least one preselected component of the mixture mixed with other less strongly adsorbed components of the mixture; c. feeding said preselected fraction of the mixture into the eluting column; d. rearranging the columns so that the previously regenerating column now acts as the enriching column, the previously enriching column acting as stripping column and the previously stripping column now acting as regenerating column; e. recovering a fraction of the mixture enriched in more strongly adsorbed components of the mixture at the outlet of the renererating column; and f. separating said preselected fraction in said eluting column into at least two fractions from which one fraction is enriched in said preselected component with recovery of said fractions at the outlet of the eluting column; the separation and recovering of the fractions enriched in less strongly adsorbed components of the mixture and in said preselected component being carried out by means of the first carrier gas stream, the recovering of the fraction enriched in more strongly adsorbed components being carried out by means of the second carrier gas stream.
Claim 2
Independent Claim
286 words
A method of chromatographic separation of fluid mixtures into fractions using four chromatographic columns connected into a circulation path adapted for simultaneous passing of two independent carrier gas streams through separated series parts of said path, in which method at each moment one column acts as enriching column, the second as stripping column, the third as regenerating column, the fourth acting as eluting column, the method comprising steps of: a. continuously introducing the mixture to be separated at constant flow rate into a pipe connecting the stripping column to the enriching column; b. recovering at the outlet of the enriching column a preselected fraction of the mixture containing at least one preselected component of the mixture mixed with other less strongly adsorbed components of the mixture; c. feeding said preselected fraction of the mixture into the eluting column; d. rearranging the columns so that the previously regenerating column now acts as the enriching column, the previously enriching column acting as stripping column and the previously stripping column now acting as regenerating column; e. recovering a fraction of the mixture enriched in more strongly adsorbed components of the mixture at the outlet of the renererating column; and f. separating said preselected fraction in said eluting column into at least two fractions from which one fraction is enriched in said preselected component with recovery of said fractions at the outlet of the eluting column; the separation and recovering of the fractions enriched in less strongly adsorbed components of the mixture and in said preselected component being carried out by means of the first carrier gas stream, the recovering of the fraction enriched in more strongly adsorbed components being carried out by means of the second carrier gas stream.
Claim 3
Independent Claim
288 words
A method of chromatographic separation of fluid mixtures into fractions using four chromatograhic columns connected into a circulation path adapted for simultaneous passing of two independent carrier gas streams through separated series parts of said path, in which method at each moment one column acts as stripping column, the second as enriching column, the third as regenerating column, the fourth acting as eluting column, the method comprising steps of: a. continuously introducing the mixture to be separated at constant flow rate into a pipe connecting the enriching column to the stripping column; b. recovering a fraction of the mixture enriched in less strongly adsorbed components of the mixture at the outlet of the stripping column; c. rearranging the columns so that the previously stripping column now acts as enriching column, the previously enriching column now acting as regenerating column and the previously regenerating column now acting as stripping column; d. recovering at the outlet of the enriching column a preselected fraction of the mixture containing at least one preselected component of the mixture mixed with other more strongly adsorbed components; e. feeding said preselected fraction of the mixture into the eluting column; and f. separating said preselected fraction in said eluting columns into at least two fractions from which one fraction is enriched in said preselected component with recovery of said fractions at the outlet of the eluting column; the separation and recovery of the fraction enriched in less strongly adsorbed components of the mixture being carried out by means of the first carrier gas stream, the separation and recovering of the fractions enriched in said preselected component and in more strongly adsorbed components of the mixture being carried out by means of the second carrier gas stream.
Claim 4
Independent Claim
288 words
A method of chromatographic separation of fluid mixtures into fractions using four chromatograhic columns connected into a circulation path adapted for simultaneous passing of two independent carrier gas streams through separated series parts of said path, in which method at each moment one column acts as stripping column, the second as enriching column, the third as regenerating column, the fourth acting as eluting column, the method comprising steps of: a. continuously introducing the mixture to be separated at constant flow rate into a pipe connecting the enriching column to the stripping column; b. recovering a fraction of the mixture enriched in less strongly adsorbed components of the mixture at the outlet of the stripping column; c. rearranging the columns so that the previously stripping column now acts as enriching column, the previously enriching column now acting as regenerating column and the previously regenerating column now acting as stripping column; d. recovering at the outlet of the enriching column a preselected fraction of the mixture containing at least one preselected component of the mixture mixed with other more strongly adsorbed components; e. feeding said preselected fraction of the mixture into the eluting column; and f. separating said preselected fraction in said eluting columns into at least two fractions from which one fraction is enriched in said preselected component with recovery of said fractions at the outlet of the eluting column; the separation and recovery of the fraction enriched in less strongly adsorbed components of the mixture being carried out by means of the first carrier gas stream, the separation and recovering of the fractions enriched in said preselected component and in more strongly adsorbed components of the mixture being carried out by means of the second carrier gas stream.
Claim 5
Dependent Claim
215 words
Apparatus for chromatographic separation which comprises: a. first, second, third and fourth chromatographic separating columns; b. first and second sources of carrier gas; c. means for passing said first carrier gas stream through said first, second and fourth separating columns connected in series; d. means for continuously introducing a mixture to be separated at constant flow rate into a pipe connecting said first and second columns; e. means for passing said second carrier gas stream through said third column simultaneously with the passing of said first carrier gas stream through the other columns; f. means for removing a fraction of the mixture enriched in more strongly adsorbed components from the outlet of said third separating column; g. means for removing at least two fractions of the mixture enriched correspondingly in a preselected component of the mixture and in less strongly adsorbed components from the outlet of said fourth separating column; and h. means for shifting the inlet points of the mixture to be separated, the inlet of the fourth column and the inlet and outlet points of said carrier gas streams along said first, second and third column in the direction of gas flow periodically and simultaneously, each time said third column being connected between said second and fourth columns, said second column being isolated.
Claim 6
Dependent Claim
215 words
Apparatus for chromatographic separation which comprises: a. first, second, third and fourth chromatographic separating columns; b. first and second sources of carrier gas; c. means for passing said first carrier gas stream through said first, second and fourth separating columns connected in series; d. means for continuously introducing a mixture to be separated at constant flow rate into a pipe connecting said first and second columns; e. means for passing said second carrier gas stream through said third column simultaneously with the passing of said first carrier gas stream through the other columns; f. means for removing a fraction of the mixture enriched in more strongly adsorbed components from the outlet of said third separating column; g. means for removing at least two fractions of the mixture enriched correspondingly in a preselected component of the mixture and in less strongly adsorbed components from the outlet of said fourth separating column; and h. means for shifting the inlet points of the mixture to be separated, the inlet of the fourth column and the inlet and outlet points of said carrier gas streams along said first, second and third column in the direction of gas flow periodically and simultaneously, each time said third column being connected between said second and fourth columns, said second column being isolated.
Claim 7
Dependent Claim
230 words
Apparatus for chromatographic separation which comprises: a. first, second, third and fourth chromatographic separating columns; b. first and second sources of carrier gas; c. means for passing said first carrier gas stream through said first and second separating columns connected in series, d. means for continuously introducing a mixture to be separated at constant flow rate into a pipe connecting said first and second columns; e. means for passing said second carrier gas stream through said third and fourth separating columns connected in series, simultaneously with the passing of said first carrier gas stream through the other columns; f. means for removing a fraction of the mixture enriched in less strongly adsorbed components of the mixture from the outlet of said second separating column; g. means for removing at least two fractions of the mixture enriched correspondingly in a preselected component of the mixture and in more strongly adsorbed components from the outlet of said fourth separating column; and h. means for shifting the inlet points of the mixture to be separated, the inlet of the fourth column and the inlet and outlet points of said carrier gas streams along said first, second and third columns in the direction of gas flow periodically and simultaneously, each time said third column being connected to the outlet of said second column and said fourth column to the outlet of said first column.
Claim 8
Dependent Claim
230 words
Apparatus for chromatographic separation which comprises: a. first, second, third and fourth chromatographic separating columns; b. first and second sources of carrier gas; c. means for passing said first carrier gas stream through said first and second separating columns connected in series, d. means for continuously introducing a mixture to be separated at constant flow rate into a pipe connecting said first and second columns; e. means for passing said second carrier gas stream through said third and fourth separating columns connected in series, simultaneously with the passing of said first carrier gas stream through the other columns; f. means for removing a fraction of the mixture enriched in less strongly adsorbed components of the mixture from the outlet of said second separating column; g. means for removing at least two fractions of the mixture enriched correspondingly in a preselected component of the mixture and in more strongly adsorbed components from the outlet of said fourth separating column; and h. means for shifting the inlet points of the mixture to be separated, the inlet of the fourth column and the inlet and outlet points of said carrier gas streams along said first, second and third columns in the direction of gas flow periodically and simultaneously, each time said third column being connected to the outlet of said second column and said fourth column to the outlet of said first column.
Claim 9
Dependent Claim
221 words
The apparatus according to claim 4, wherein said means for shifting the inlet points of the mixture to be separated, the inlet of the fourth column and the inlet and outlet points of said carrier gas streams are made in the form of a valve unit having a body with three channels made in it in one direction and connected at one end to the first, second and third column inlets and with the means for passing said carrier gas streams through the columns, and at the other end connected to the outlets of the same columns, while in a substantially transverse direction to said channels in the same body three other channels are made being plugged at one end thereof, the other end of one of said three latter channels being connected to the means for continuously introducing the mixture to be separated, at each crossing of one channel over the other a membrane valve being mounted connecting said channels with each other, each of the channels connecting the inlets and outlets of the columns together being interrupted under the membrane of the valve connecting said channel to the means for introducing the mixture, while the inlet of the fourth column is connected to the free end of one of said two channels being plugged at the other end thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-11-16 | 1980-05-17 | 1980-11-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-11-16 | 1984-05-17 | 1984-11-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-11-16 | 1988-05-17 | 1988-11-16 | $7700.00 | Window Closed / Lapsed |