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US3989707A
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Benzimidazolinone derivatives
Assignee: Janssen Pharmaceutica NV
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Filing: 1974-06-21
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Granted: 1976-11-02
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Expires: 1994-06-21
Abstract
Abstract Novel benzimidazolinone derivatives and therapeutically acceptable acid addition salts thereof, said compounds being useful as long acting neuroleptic agents.
Inventors
- 👤 Paul Adriaan Jan Janssen
- 👤 Albert H. M. Th. Van Heertum
- 👤 Jan Vandenberk
- 👤 Marcel J. M. C. Van der Aa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 20:21
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/04; C07D211/00; C07D211/04; C07D211/68; C07D211/72; C07D211/78; A; A61; A61P; A61P25/00; A61P25/20; C07D211/06; C07D211/36; C07D211/56; C07D211/58; G; G01; G01N; G01N21/00; G01N21/75; G01N21/76; G01N21/766; G01N31/00; G01N31/10; Y; Y10; Y10T; Y10T436/00; Y10T436/17; Y10T436/173845; Y10T436/175383; Y10T436/177692; Y10T436/178459
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
127 words
A compound selected from the group consisting of a benzimidazolinone derivative having the formula: ##SPC10## and the therapeutically acceptable acid addition salts thereof, wherein: Ar 1 and Ar 2 are each a member independently selected from the group consisting of phenyl, halophenyl and trifluoromethylphenyl; R 1 is a member selected from the group consisting of halo, loweralkyl and trifluoromethyl; R 2 is a member selected from the group consisting of hydrogen, halo, loweralkyl and trifluoromethyl; R 3 is a member selected from the group consisting of hydrogen and methyl, provided that, when said R 3 is methyl, then said R 3 is in the 2- or 3-position of the piperidine-nucleus; and L is a member selected from the group consisting of hydrogen, loweralkyl, loweralkyloxycarbonyl-loweralkyl, loweralkylcarbonyl-loweralkyl and phenyl-loweralkyl.
Claim 2
Dependent Claim
127 words
A compound selected from the group consisting of a benzimidazolinone derivative having the formula: ##SPC10## and the therapeutically acceptable acid addition salts thereof, wherein: Ar 1 and Ar 2 are each a member independently selected from the group consisting of phenyl, halophenyl and trifluoromethylphenyl; R 1 is a member selected from the group consisting of halo, loweralkyl and trifluoromethyl; R 2 is a member selected from the group consisting of hydrogen, halo, loweralkyl and trifluoromethyl; R 3 is a member selected from the group consisting of hydrogen and methyl, provided that, when said R 3 is methyl, then said R 3 is in the 2- or 3-position of the piperidine-nucleus; and L is a member selected from the group consisting of hydrogen, loweralkyl, loweralkyloxycarbonyl-loweralkyl, loweralkylcarbonyl-loweralkyl and phenyl-loweralkyl.
Claim 3
Dependent Claim
1 words
5-Chloro-1-{1-[4,4-bis(p-fluorophenyl)butyl]-4-piperidyl}-2-benzimidazolinone.
Claim 4
Dependent Claim
1 words
5-Chloro-1-{1-[4,4-bis(p-fluorophenyl)butyl]-4-piperidyl}-2-benzimidazolinone.
Claim 5
Dependent Claim
2 words
5,6-Dichloro-1-{1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one 2-propanolate.
Claim 6
Dependent Claim
2 words
5,6-Dichloro-1-{1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one 2-propanolate.
Claim 7
Dependent Claim
1 words
5-Chloro-1-{1-[4,4-bis(4-fluorophenyl)butyl]-3-methyl-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one.
Claim 8
Dependent Claim
1 words
5-Chloro-1-{1-[4,4-bis(4-fluorophenyl)butyl]-3-methyl-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one.
Claim 9
Dependent Claim
1 words
5-Bromo-1-{1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one.
Claim 10
Dependent Claim
1 words
5-Bromo-1-{1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one.
Claim 11
Dependent Claim
2 words
Methyl 5-chloro-1-{1-[4,4-bis(4-fluorophenyl)-butyl]-4-piperidinyl}-1,3-dihydro-2-oxo-2H-benzimidazole-2-propanoate.
Claim 12
Dependent Claim
2 words
Methyl 5-chloro-1-{1-[4,4-bis(4-fluorophenyl)-butyl]-4-piperidinyl}-1,3-dihydro-2-oxo-2H-benzimidazole-2-propanoate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-11-02 | 1980-05-03 | 1980-11-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-11-02 | 1984-05-03 | 1984-11-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-11-02 | 1988-05-03 | 1988-11-02 | $7700.00 | Window Closed / Lapsed |