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US3988482A
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Menthol glycoside, process for preparing the same and method for releasing menthol therefrom
Assignee: Toyo Hakka Kogyo Co Ltd
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Filing: 1974-09-20
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Granted: 1976-10-26
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Expires: 1994-09-20
Abstract
Abstract Water-soluble menthol glycosides are prepared by condensing menthol with a mono- or oligosaccharide, preferably a mono- or disaccharide, i.e., a sugar, or acyl derivative thereof, using a condensing agent or catalyst as needed. These glycosides are hydrolyzed by carbohydrase enzymes, as occur in the human mouth, or common acids, releasing menthol, and provide a more persistent flavor than menthol alone.
Inventors
- 👤 Tatsuo Higashiyama
- 👤 Isao Sakata
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 22:32
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/18; A; A23; A23L; A23L27/00; A23L27/20; A23L27/203; A23L27/70; A23L27/75; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/60; A61K8/602; A61Q; A61Q11/00
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
122 words
The method of manifesting upon oral or topical administration to a human being the inherent flavor and feeling of menthol in an aqueous base composition in which menthol is normally insoluble, which comprises the steps of providing in said composition a water-soluble menthol derivative having the formula: ##SPC7## wherein: R is the residue of a mono- or oligosaccharide and n is the number of hydroxyl groups on said mono- or oligosaccharide and is at least 5, and orally or topically administering said composition to a human being, and effecting hydrolysis of said derivative in the administered composition by a carbohydrase enzyme or an acid harmless to human beings to thereby regenerate free menthol from said derivative and manifest said flavor and feeling.
Claim 2
Independent Claim
122 words
The method of manifesting upon oral or topical administration to a human being the inherent flavor and feeling of menthol in an aqueous base composition in which menthol is normally insoluble, which comprises the steps of providing in said composition a water-soluble menthol derivative having the formula: ##SPC7## wherein: R is the residue of a mono- or oligosaccharide and n is the number of hydroxyl groups on said mono- or oligosaccharide and is at least 5, and orally or topically administering said composition to a human being, and effecting hydrolysis of said derivative in the administered composition by a carbohydrase enzyme or an acid harmless to human beings to thereby regenerate free menthol from said derivative and manifest said flavor and feeling.
Claim 3
Dependent Claim
27 words
The method of claim 1 wherein said composition is administered orally and said hydrolysis is effected in the oral cavity by an enzyme present in human saliva.
References Cited (Backward Citations)
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US3607651A
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US3830930A
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US3818107A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-26 | 1980-04-26 | 1980-10-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-26 | 1984-04-26 | 1984-10-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-26 | 1988-04-26 | 1988-10-26 | $7700.00 | Window Closed / Lapsed |