Patent US3988475A successfully refreshed from Google Patents.
US3988475A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Phenoxyalkylamines
Assignee: Istituto Luso Farmaco dItalia SpA
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Filing: 1975-01-31
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Granted: 1976-10-26
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Expires: 1995-01-31
Abstract
Abstract The invention provides a new class of aminoalkoxyphenoxyalkenones having interesting pharmacological properties.
Inventors
- 👤 Elso Manghisi
- 👤 Aldo Salimbeni
- 👤 Giancarlo Fregnan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 16:17
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088; A; A61; A61P; A61P7/00; A61P7/02; A61P9/00; A61P9/06; A61P9/12; C07D211/00; C07D211/04; C07D211/06; C07D211/36; C07D211/40; C07D211/44; C07D211/52
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
197 words
A phenoxyalkylamine of the formula: ##SPC5## and its stereoisomers and optical isomers, and pharmaceutically acceptable acid addition salts, in which the ##EQU1## group may be in the ortho, meta or para position, R 1 is a linear or branched alkyl of 1 to 4 carbon atoms, or a monocarbocyclic aryl group, unsubstituted or substituted by one or more halogen atoms, or methyl or methoxy grups; R 2 is an alkyl of 1 to 4 carbon atoms or a monocarbocyclic aryl group unsubstituted or substituted by one or more halogen atoms, or alkyls of 1 to 4 carbon atoms, or methoxy groups; Alk is a linear or branched alkylene chain of 1 to 4 carbon atoms, or a hydroxy alkylene chain; and R 3 and R 4 , which are the same or different, are each hydrogen, alkyl of 1 to 4 carbon atoms each, dialkylaminoalkyl of up to 4 carbon atoms in each alkyl, carbocyclic aryl, cycloalkyl of 3 to 8 carbon atoms, carbocyclic arylalkyl of 1 to 4 carbon atoms in the alkyl, or hydroxyalkyl of up to 4 carbon atoms in which the hydroxyl is separated from the nitrogen by at least two carbon atoms.
Claim 2
Dependent Claim
197 words
A phenoxyalkylamine of the formula: ##SPC5## and its stereoisomers and optical isomers, and pharmaceutically acceptable acid addition salts, in which the ##EQU1## group may be in the ortho, meta or para position, R 1 is a linear or branched alkyl of 1 to 4 carbon atoms, or a monocarbocyclic aryl group, unsubstituted or substituted by one or more halogen atoms, or methyl or methoxy grups; R 2 is an alkyl of 1 to 4 carbon atoms or a monocarbocyclic aryl group unsubstituted or substituted by one or more halogen atoms, or alkyls of 1 to 4 carbon atoms, or methoxy groups; Alk is a linear or branched alkylene chain of 1 to 4 carbon atoms, or a hydroxy alkylene chain; and R 3 and R 4 , which are the same or different, are each hydrogen, alkyl of 1 to 4 carbon atoms each, dialkylaminoalkyl of up to 4 carbon atoms in each alkyl, carbocyclic aryl, cycloalkyl of 3 to 8 carbon atoms, carbocyclic arylalkyl of 1 to 4 carbon atoms in the alkyl, or hydroxyalkyl of up to 4 carbon atoms in which the hydroxyl is separated from the nitrogen by at least two carbon atoms.
Claim 3
Dependent Claim
56 words
A phenoxyalkylamine according to claim 1 and its pharmaceutically acceptable acid addition salts in which the ##STR9## group is in the ortho or para position, R 1 is methyl or phenyl, R 2 is phenyl or 4-chlorophenyl, Alk is ethylene, propylene, isopropylene or hydroxypropylene, and R 3 and R 4 are each hydrogen, methyl, ethyl, tert-butyl.
Claim 4
Dependent Claim
14 words
A phenoxyalkylamine of claim 1 comprising 3-[o-(β-N,N-Diethylaminoethoxy)-phenoxy]-4-phenyl-3-buten-2-one, and its pharmaceutically acceptable acid addition salts.
Claim 5
Dependent Claim
14 words
A phenoxyalkylamine of claim 1 comprising 1,3-Diphenyl-2-[o-(β-N,N-diethylaminoethoxy)-phenoxy]-2-propen-1-one, and its pharmaceutically acceptable acid addition salts.
Claim 6
Dependent Claim
14 words
A phenoxyalkylamine of claim 1 comprising 3-[p-(β-N,N-Di-ethylaminoethoxy)-phenoxy]-4-phenyl-3-buten-2-one, and its pharmaceutically acceptable acid addition salts.
Claim 7
Dependent Claim
14 words
A phenoxyalkylamine of claim 1 comprising 3-[o-(y-N,N-Dimethylaminopropoxy)-phenoxy]-4-phenyl-3-buten-2one, and its pharamaceutically acceptable acid addition salts.
Claim 8
Dependent Claim
14 words
A phenoxyalkylamine of claim 1 comprising 3-[o-(y-N-tert-Butylamino-β-hydroxy-propoxy)phenoxy]-4-phenyl-3-buten-2-one, and its pharmaceutically acceptable acid addition salts.
Claim 9
Dependent Claim
15 words
A phenoxyalkylamine of claim 1 comprising 3-[o-(y-N-tert-Butylamino propoxy)-phenoxy]-4-phenyl-3-buten-2-one, and its pharmaceutically acceptable acid addition salts.
Claim 10
Dependent Claim
15 words
A phenoxyalkylamine of claim 1 comprising 3-[p-(y-N-Methylamino propoxy)-phenoxy]-4-phenyl-3-buten-2-one, and its pharamaceutically acceptable acid addition salts.
Claim 11
Dependent Claim
15 words
A phenoxyalkylamine of claim 1 comprising 3-[p-(β-Methyl-β-N,N-dimethylamino ethoxy)-phenoxy]-4-phenyl-3-buten-2-one, and its pharmaceutically acceptable acid addition salts.
Claim 12
Dependent Claim
15 words
A phenoxyalkylamine of claim 1 comprising 3-[p-(y-N-tert-Butylamino-β-hydroxy propoxy)-phenoxy]-4-phenyl-3-buten-2-one, and its pharmaceutically acceptable acid addition salts.
Claim 13
Dependent Claim
15 words
A phenoxyalkylamine of claim 1 comprising 3-[p-(β-N,N-Diethylamino ethoxy)-phenoxy]-4-p-chlorophenyl-3-buten-2-one, and its pharmaceutically acceptable acid addition salts.
Claim 14
Dependent Claim
38 words
A pharmaceutical composition comprising as active principle one or more compounds as claimed in claim 1, in the form of free base or pharmaceutically acceptable salt, in association with a significant amount of pharmaceutically acceptable and compatible carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-26 | 1980-04-26 | 1980-10-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-26 | 1984-04-26 | 1984-10-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-26 | 1988-04-26 | 1988-10-26 | $7700.00 | Window Closed / Lapsed |