US3987157A
Expired / Lapsed
US
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Technetium 99-m labeled radio-diagnostic agents employing stannous tartrate and method of preparation
Assignee: CINTICHEM Inc
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Filing: 1974-08-29
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Granted: 1976-10-19
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Expires: 1994-08-29
Abstract
Abstract A method of preparing improved technetium-99m labeled radiodiagnostic agents by reducing technetium-99m with stannous tartrate. Such radiodiagnostic agents are useful in scintigraphic examinations of the bone and lung.
Inventors
- 👤 Victor J. Molinski
- 👤 Joseph A. Wilczewski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 00:06
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/081; A61K51/12; A61K51/1217; A61K51/1241; A61K51/1255; A61K2123/00
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
87 words
A method of preparing a stable, non-radioactive carrier comprising: a. contacting a sequestering agent with a sufficient amount of a non-oxidizing acid to form a solution containing said sequestering agent having a pH from about 2 to about 7, said sequestering agent selected from the group consisting of a phosphorus-containing compound which contains a P-O-P linkage and a phosphonate which contains P-C-P bonds; and b. dissolving stannous tartrate in said solution to form a stannous tartrate containing solution having a pH between about 2 and about 7.
Claim 2
Independent Claim
87 words
A method of preparing a stable, non-radioactive carrier comprising: a. contacting a sequestering agent with a sufficient amount of a non-oxidizing acid to form a solution containing said sequestering agent having a pH from about 2 to about 7, said sequestering agent selected from the group consisting of a phosphorus-containing compound which contains a P-O-P linkage and a phosphonate which contains P-C-P bonds; and b. dissolving stannous tartrate in said solution to form a stannous tartrate containing solution having a pH between about 2 and about 7.
Claim 3
Dependent Claim
24 words
A method as defined in claim 1 wherein said nonoxidizing acid is selected from the group consisting of hydrochloric, acetic, sulfuric and phosphoric acid.
Claim 4
Dependent Claim
52 words
A method as defined in claim 1 wherein said sequestering agent is selected from the group consisting of sodium pyrophosphate, sodium tripolyphosphate, sodium orthophosphate, sodium polyphosphate, 1-hydroxyethylidene-1, 1-disodium phosphonate (HEDSPA), sodium methylene disphosphonate, the mono substituted salts of sodium methylene disphosphonate, the mono substituted salts of sodium dichloromethylene diphosphonate and 1-hydroxyethylidene-1-mono-sodium phosphonate.
Claim 5
Dependent Claim
13 words
A method as defined in claim 3 wherein said sequestering agent is HEDSPA.
Claim 6
Dependent Claim
29 words
A method as defined in claim 4 wherein the pH of said HEDSPA-containing solution is about 6 and the pH of said stannous tartrate containing solution is about 4.
Claim 7
Dependent Claim
38 words
A method as defined in claim 4 wherein said stannous tartrate is added to said HEDSPA-containing solution in an amount between about 3 to 1 and 20 to 1 of HEDSPA to stannous tartrate on a weight basis.
Claim 8
Dependent Claim
22 words
A method as defined in claim 1 wherein said stannous tartrate containing solution is lyophilized at a temperature below about 0° C.
Claim 9
Dependent Claim
19 words
A method as defined in claim 7 wherein said lyophilization temperature is between about 0° C and -10° C.
Claim 10
Dependent Claim
38 words
A method as defined in claim 1 wherein said stannous tartrate containing solution is contacted with a sufficient amount of a saline solution of Na 99m TcO 4 to form a 99m Tc-labeled solution containing said sequestering agent.
Claim 11
Independent Claim
114 words
A method of preparing a stable, non-radioactive macroaggregated albumin carrier comprising: a. contacting a saline solution with a sufficient amount of a non-oxidizing acid to adjust the pH of said solution to between about 2 and about 6; b. introducing stannous tartrate and human serum albumin into said solution to form a stannous tartrate containing solution; c. adding a sufficient amount of sodium hydroxide to adjust the pH of said stannous tartrate containing solution to between about 5 and about 6; d. heating said pH adjusted solution a predetermined time at a temperature sufficient to macroaggregate the albumin, said macroaggregated albumin comprising particles sized between about 3 microns and about 150 microns in diameter.
Claim 12
Independent Claim
114 words
A method of preparing a stable, non-radioactive macroaggregated albumin carrier comprising: a. contacting a saline solution with a sufficient amount of a non-oxidizing acid to adjust the pH of said solution to between about 2 and about 6; b. introducing stannous tartrate and human serum albumin into said solution to form a stannous tartrate containing solution; c. adding a sufficient amount of sodium hydroxide to adjust the pH of said stannous tartrate containing solution to between about 5 and about 6; d. heating said pH adjusted solution a predetermined time at a temperature sufficient to macroaggregate the albumin, said macroaggregated albumin comprising particles sized between about 3 microns and about 150 microns in diameter.
Claim 13
Dependent Claim
23 words
A method as defined in claim 10 wherein said nonoxidizing acid is selected from the group consisting of hydrochloric, acetic, sulfuric and phosphoric.
Claim 14
Dependent Claim
14 words
A method as defined in claim 11 wherein said nonoxidizing acid is hydrochloric acid.
Claim 15
Dependent Claim
33 words
A method as defined in claim 10 wherein the pH of said saline solution is about 5.5 and the pH of said stannous tartrate containing solution is between about 5.5 and about 5.6.
Claim 16
Dependent Claim
32 words
A method as defined in claim 10 wherein said predetermined time is between about 20 minutes and about 40 minutes and said temperature is between about 70° C and about 80° C.
Claim 17
Dependent Claim
22 words
A method as defined in claim 14 wherein said predetermined time is about 25 minutes and said temperature is about 74° C.
Claim 18
Dependent Claim
35 words
A method as defined in claim 10 further including the step of adding a preservative to said stannous tartrate containing solution, said preservative selected from the group consisting of thimerosal, methyl and propyl p-hydroxy benzoates.
Claim 19
Dependent Claim
22 words
A method as defined in claim 10 wherein said stannous tartrate containing solution is lyophilized at a temperature below about 0° C.
Claim 20
Dependent Claim
19 words
A method as defined in claim 17 wherein said lyophilization temperature is between about 0° C and -10° C.
Claim 21
Dependent Claim
30 words
A method as defined in claim 10 wherein said particles are sized between about 10 microns and about 90 microns in diameter, a majority being about 50 microns in diameter.
Claim 22
Dependent Claim
36 words
A method as defined in claim 10 wherein said stannous tartrate containing solution is contacted with a sufficient amount of a saline solution of Na 99m TcO 4 to form a 99m Tc-labeled macroaggregated albumin solution.
Claim 23
Dependent Claim
45 words
A stable, non-radioactive carrier comprising stannous ion chelated with tartrate and a sequestering agent selected from the group consisting of a phosphorus-containing compound which contains a P-O-P linkage and phosphonate which contains P-C-P bonds, said carrier having a pH between about 2 and about 7.
Claim 24
Dependent Claim
45 words
A stable, non-radioactive carrier comprising stannous ion chelated with tartrate and a sequestering agent selected from the group consisting of a phosphorus-containing compound which contains a P-O-P linkage and phosphonate which contains P-C-P bonds, said carrier having a pH between about 2 and about 7.
Claim 25
Dependent Claim
15 words
A carrier as defined in claim 21 wherein said sequestering agent is an inorganic phosphate.
Claim 26
Dependent Claim
15 words
A carrier as defined in claim 21 wherein said sequestering agent is an organic phosphonate.
Claim 27
Dependent Claim
16 words
A carrier as defined in claim 23 wherein said organic phosphonate is 1-hydroxyethylidene-1, 1-disodium phosphonate (HEDSPA).
Claim 28
Dependent Claim
16 words
A carrier as defined in claim 24 wherein the pH of said carrier is about 4.
Claim 29
Dependent Claim
34 words
A carrier as defined in claim 24 wherein on a weight basis, the ratio of said HEDSPA to said stannous ion chelated with tartrate is between about 3 to 1 and 20 to 1.
Claim 30
Dependent Claim
47 words
A radiodiagnostic agent suitable for bone scanning comprising stannous ion chelated with tartrate, a sequestering agent selected from the group consisting of a phosphorus-containing compound which contains a P-O-P linkage and a phosphonate which contains P-C-P bonds, and a saline solution of Na 99m TcO 4 .
Claim 31
Dependent Claim
47 words
A radiodiagnostic agent suitable for bone scanning comprising stannous ion chelated with tartrate, a sequestering agent selected from the group consisting of a phosphorus-containing compound which contains a P-O-P linkage and a phosphonate which contains P-C-P bonds, and a saline solution of Na 99m TcO 4 .
Claim 32
Dependent Claim
46 words
A stable, non-radioactive macroaggregated albumin carrier, said carrier comprising a macroaggregated human serum albumin and stannous ion chelated with tartrate, said carrier having a pH between about 5 and about 6said macroaggregated albumin comprising particles sized between about 3 microns and about 150 microns in diameter.
Claim 33
Dependent Claim
46 words
A stable, non-radioactive macroaggregated albumin carrier, said carrier comprising a macroaggregated human serum albumin and stannous ion chelated with tartrate, said carrier having a pH between about 5 and about 6said macroaggregated albumin comprising particles sized between about 3 microns and about 150 microns in diameter.
Claim 34
Dependent Claim
20 words
A carrier as defined in claim 27 wherein the pH of said carrier is between about 5.5 and about 5.6.
Claim 35
Dependent Claim
28 words
A carrier as defined in claim 27 wherein said particles are sized between about 10 microns and about 90 microns, the majority being about 50 microns in diameter.
Claim 36
Dependent Claim
28 words
A radiodiagnostic agent suitable for lung scanning comprising a macroaggregated human serum albumin, stannous ion chelated with tartrate and a saline solution of Na 99m TcO 4 .
Claim 37
Dependent Claim
28 words
A radiodiagnostic agent suitable for lung scanning comprising a macroaggregated human serum albumin, stannous ion chelated with tartrate and a saline solution of Na 99m TcO 4 .
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-19 | 1980-04-19 | 1980-10-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-19 | 1984-04-19 | 1984-10-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-19 | 1988-04-19 | 1988-10-19 | $7700.00 | Window Closed / Lapsed |