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US3986929A
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Antibiotic from micromonospora purpurea ji-20
Assignee: Merck Sharp & Dohme LLC
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Filing: 1975-06-09
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Granted: 1976-10-19
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Expires: 1995-06-09
Abstract
Abstract A mutant strain of Micromonospora purpurea herein designated M. purpurea JI-20 elaborates an antibiotic complex comprising gentamicin and at least two novel antibiotic substances namely Antibiotic JI-20A and Antibiotic JI-20B. The so-produced antibiotics have an adverse effect upon the growth of gram-positive and gram-negative bacteria.
Inventors
- 👤 Jan Ilavsky
- 👤 Aris P. Bayan
- 👤 William Charney
- 👤 Hans Reimann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 05:54
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/22; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/863; Y10S435/865
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
47 words
A process which comprises cultivating Micromonospora purpurea JI-20 under aerobic conditions in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen until a composition having substantial antibiotic activity is produced and separating said composition, consisting of gentamicin, Antibiotic JI-20A and Antibiotic JI-20B, from said medium.
Claim 2
Dependent Claim
47 words
A process which comprises cultivating Micromonospora purpurea JI-20 under aerobic conditions in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen until a composition having substantial antibiotic activity is produced and separating said composition, consisting of gentamicin, Antibiotic JI-20A and Antibiotic JI-20B, from said medium.
Claim 3
Dependent Claim
38 words
A process according to claim 1 wherein the composition having antibiotic activity is separated from the medium by acidifying the medium, separating the mycelium from the broth, neutralizing the broth and extracting said antibiotic composition from the broth.
Claim 4
Dependent Claim
17 words
A process according to claim 2 including the step of isolating said antibiotic composition in solid form.
Claim 5
Dependent Claim
20 words
The process of claim 3 including the steps of resolving the antibiotic composition into gentamicin, Antibiotic JI-20A and Antibiotic JI-20B.
Claim 6
Dependent Claim
17 words
The process according to claim 4 including the further step of isolating Antibiotic JI-20A and Antibiotic JI-20B.
Claim 7
Dependent Claim
19 words
The process of claim 3 including the further step of transforming the antibiotic composition into an acid addition salt.
References Cited (Backward Citations)
US3136704A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-19 | 1980-04-19 | 1980-10-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-19 | 1984-04-19 | 1984-10-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-19 | 1988-04-19 | 1988-10-19 | $7700.00 | Window Closed / Lapsed |