US3986833A
Expired / Lapsed
US
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Test composition, device, and method for the detection of peroxidatively active substances
Assignee: Bayer Corp
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Filing: 1975-09-08
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Granted: 1976-10-19
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Expires: 1995-09-08
Abstract
Abstract Improved test compositions, devices and methods are provided for detecting peroxidatively active substances in body fluids, excreta and the like. In the type of test compositions including an indicator capable of being oxidized in the presence of a peroxidatively active substance to provide a color change, an oxidizing agent effective to oxidize said indicator, and a potentiating agent, the improvement comprises the use as said potentiating agent of an acid salt or adduct of a compound selected from the class of compounds of the general formula ##SPC1## Wherein R 1 is hydrogen, lower alkyl, hydroxy or thiophenyl; R 2 is hydrogen or lower alkyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, carboxy, lower alkyl or lower alkoxy; and R 5 is hydrogen or lower alkyl.
Inventors
- 👤 Raymond L. Mast
- 👤 Charles Tak Wai Lam
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:17
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/26; C12Q1/28; Y; Y10; Y10S; Y10S436/00; Y10S436/904
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
119 words
A test composition for detection of peroxidatively active substances in body fluids, body excreta and the like, of the type including an indicator capable of being oxidized in the presence of a peroxidatively active substance to provide a color change, an oxidizing agent effective to oxidize said indicator, and a potentiating agent, wherein said potentiating agent comprises a water soluble acid salt or adduct of a compound selected from the class of compounds having the formula ##SPC3## wherein R 1 is hydrogen, lower alkyl, hydroxy or thiophenyl; R 2 is hydrogen or lower alkyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, carboxy, lower alkyl or lower alkoxy; and R 5 is hydrogen or lower alkyl.
Claim 2
Dependent Claim
119 words
A test composition for detection of peroxidatively active substances in body fluids, body excreta and the like, of the type including an indicator capable of being oxidized in the presence of a peroxidatively active substance to provide a color change, an oxidizing agent effective to oxidize said indicator, and a potentiating agent, wherein said potentiating agent comprises a water soluble acid salt or adduct of a compound selected from the class of compounds having the formula ##SPC3## wherein R 1 is hydrogen, lower alkyl, hydroxy or thiophenyl; R 2 is hydrogen or lower alkyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, carboxy, lower alkyl or lower alkoxy; and R 5 is hydrogen or lower alkyl.
Claim 3
Dependent Claim
20 words
A composition according to claim 1, wherein said acid salt or adduct is a mineral acid salt water soluble adduct.
Claim 4
Dependent Claim
21 words
A composition according to claim 1, wherein said water soluble acid salt or adduct is an organic acid salt or adduct.
Claim 5
Dependent Claim
11 words
A composition according to claim 1, wherein said compound is 6-methoxyquinoline.
Claim 6
Dependent Claim
13 words
A composition according to claim 4, wherein said potentiating agent is 6-methoxyquinoline sulfate.
Claim 7
Dependent Claim
13 words
A composition according to claim 4, wherein said potentiating agent is 6-methoxyquinoline hydrochloride.
Claim 8
Dependent Claim
13 words
A composition according to claim 4, wherein said potentiating agent is 6-methoxyquinoline phosphate.
Claim 9
Dependent Claim
13 words
A composition according to claim 4, wherein said potentiating agent is 6-methoxyquinoline malonate.
Claim 10
Dependent Claim
15 words
A composition according to claim 4, wherein said potentiating agent is 6-methoxyquinoline sulfosalicylic acid salt.
Claim 11
Dependent Claim
15 words
A composition according to claim 4, wherein said potentiating agent is 6-methoxyquinoline tartaric acid salt.
Claim 12
Dependent Claim
20 words
A composition according to claim 1, wherein said potentiating agent is a water soluble acid salt or adduct of quinoline.
Claim 13
Dependent Claim
13 words
A composition according to claim 11, wherein said potentiating agent is quinoline sulfate.
Claim 14
Dependent Claim
20 words
A composition according to claim 1, wherein said potentiating agent is a water soluble acid salt or adduct of 6-methylquinoline.
Claim 15
Dependent Claim
20 words
A composition according to claim 1, wherein said potentiating agent is a water soluble acid salt or adduct of 7-methylquinoline.
Claim 16
Dependent Claim
20 words
A composition according to claim 1, wherein said potentiating agent is a water soluble acid salt or adduct of 2,6-dimethylquinoline.
Claim 17
Dependent Claim
20 words
A composition according to claim 1, wherein said potentiating agent is a water soluble acid salt or adduct of 4,6-dimethylquinoline.
Claim 18
Dependent Claim
101 words
A test device for detecting peroxidatively active substances in body fluids, excreta and the like, of the type having a carrier matrix incorporated with an oxidizing agent, an indicator, and a potentiating agent wherein said potentiating agent comprises a water soluble acid salt or adduct of a compound selected from the class of compounds of the general formula ##SPC4## wherein R 1 is hydrogen, lower alkyl, hydroxy or thiophenyl; R 2 is hydrogen or lower alkyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, carboxy, lower alkyl or lower alkoxy; and R 5 is hydrogen or lower alkyl.
Claim 19
Dependent Claim
101 words
A test device for detecting peroxidatively active substances in body fluids, excreta and the like, of the type having a carrier matrix incorporated with an oxidizing agent, an indicator, and a potentiating agent wherein said potentiating agent comprises a water soluble acid salt or adduct of a compound selected from the class of compounds of the general formula ##SPC4## wherein R 1 is hydrogen, lower alkyl, hydroxy or thiophenyl; R 2 is hydrogen or lower alkyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, carboxy, lower alkyl or lower alkoxy; and R 5 is hydrogen or lower alkyl.
Claim 20
Dependent Claim
63 words
A method for detecting minor amounts of a peroxidatively active substance in body fluids, excreta and the like, which comprises contacting a test sample of the body fluid or excreta with the carrier matrix of a test device as claimed in claim 17 and observing the color formation thereon as an indication of the presence of a peroxidatively active substance in said sample.
Claim 21
Dependent Claim
14 words
A method according to claim 18, wherein the peroxidatively active substance is occult blood.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-19 | 1980-04-19 | 1980-10-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-19 | 1984-04-19 | 1984-10-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-19 | 1988-04-19 | 1988-10-19 | $7700.00 | Window Closed / Lapsed |