US3853472A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Diagnostic test strip for the detection of components of body fluids
Assignee: Roche Diagnostics GmbH
•
Filing: 1973-07-03
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Granted: 1974-12-10
•
Expires: 1993-07-03
Abstract
Abstract Test strips are provided for detecting even small amounts of blood or other peroxidatively active substances in body fluids; the strips comprising a carrier containing a hydroperoxide, a chromogen, and as an activator, a compound of the formula WHEREIN R1 is a hydrogen atom or a methyl radical and benzene and/or pyridine rings are fused on at least one of the positions indicated with c, (d,e), f and g, provided that two adjacent rings must not simultaneously each contain a cyclic nitrogen atom, and wherein the aromatic compounds (1), apart from the positions indicated by H and R1, can be substituted by lower alkyl radicals which together can also form a hydroaromatic ring.
Inventors
- 👤 W Rittersdorf
- 👤 H Rey
- 👤 W Guthlein
- 👤 P Rieckmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:18
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/26; C12Q1/28; C12Q1/02; C12Q1/04; Y; Y10; Y10S; Y10S436/00; Y10S436/904
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
30 words
TEST STRIP FOR THE DETECTION OF PEROXIDATIVELY-ACTIVE SUBSTANCES IN BODY FLUID, COMPRISING A CARRIER CONTAINING A HYDROPEROXIDE, AT LEAST ONE CHROMOGEN AND, AS AN ACTIVATOR, A COMPOUND OF THE FORMULA
Claim 2
Dependent Claim
30 words
TEST STRIP FOR THE DETECTION OF PEROXIDATIVELY-ACTIVE SUBSTANCES IN BODY FLUID, COMPRISING A CARRIER CONTAINING A HYDROPEROXIDE, AT LEAST ONE CHROMOGEN AND, AS AN ACTIVATOR, A COMPOUND OF THE FORMULA
Claim 3
Dependent Claim
14 words
Test strip as claimed in claim 1, wherein R1 is formula (I) is hydrogen.
Claim 4
Dependent Claim
14 words
Test strip as claimed in claim 1, wherein R1 in formula (I) is methyl.
Claim 5
Dependent Claim
27 words
Test strip as claimed in claim 1, wherein said compound contains a benzene ring fused on at least one of the c, (d,e), f or g positions.
Claim 6
Dependent Claim
25 words
Test strip as claimed in claim 1, wherein said compound contains a pyridine ring fused on at least one of the f or g positions.
Claim 7
Dependent Claim
39 words
Test strip as claimed in claim 1, wherein said compound contains a benzene ring fused to at least one of the c, (d,e), f or g positions and a pyridine ring on one of the f and g positions.
Claim 8
Dependent Claim
31 words
Test strip as claimed in claim 1, wherein said compound is substituted in at least one available ring position by a lower alkyl radical of from one to four carbon atoms.
Claim 9
Dependent Claim
24 words
Test strip as claimed in claim 7, wherein there are two such alkyl radicals linked together to form a 5 or 6-membered hydroaromatic ring.
Claim 10
Dependent Claim
15 words
Test strip as claimed in claim 1, wherein said compound is a benzo (c) quinoline.
Claim 11
Dependent Claim
15 words
Test strip as claimeD in claim 1, wherein said compound is a benzo (f) quinoline.
Claim 12
Dependent Claim
15 words
Test strip as claimed in claim 1, wherein said compound is a benzo (g) quinoline.
Claim 13
Dependent Claim
13 words
Test strip as claimed in claim 1, wherein said compound is a dibenzoquinoline.
Claim 14
Dependent Claim
14 words
Test strip as claimed in claim 12, wherein said dibenzoquinoline is dibenzo (c,f) quinoline.
Claim 15
Dependent Claim
14 words
Test strip as claimed in claim 12, wherein said dibenzoquinoline is dibenzo (c,d,e) quinoline.
Claim 16
Dependent Claim
13 words
Test strip as claimed in claim 1, wherein said compound is a pyridoquinoline.
Claim 17
Dependent Claim
15 words
Test strip as claimed in claim 15, wherein said pyridoquinoline is a pyrido (2,3-f) quinoline.
Claim 18
Dependent Claim
15 words
Test strip as claimed in claim 16, wherein said pyridoquinoline is a pyrido (3,2-f) quinoline.
Claim 19
Dependent Claim
15 words
Test strip as claimed in claim 16, wherein said pyridoquinoline is a pyrido (2,3-g) quinoline.
Claim 20
Dependent Claim
12 words
Test strip as claimed in claim 1, wherein said compound is phenanthridine.
Claim 21
Dependent Claim
59 words
Test strip as claimed in claim 1, wherein said compound is selected from the group consisting of 2-methyl- or 2-ethyl-phenanthridine benzo (f) quinoline 1,2-tetramethylenebenzo (f) quinoline benzo (g) quinoline 4-methylbenzo (g) quinoline dibenzo (c,d,e) quinoline dibenzo (c,f) quinoline pyrido (3,2-f) quinoline 3-methyl-4,7-phenanthroline pyrido (2,3-f) quinoline 3-methylbenzo (f) quinoline 1,3-dimethylbenzo (f) quinoline 2,4-dimethylbenzo (g) quinoline 6-methylphenanthridine 3,8-dimethyl-4,7-phenanthroline 2,8-dimethyl-1,7-phenanthroline, and 2,7-dimethyl-1,6-anthrazoline
Claim 22
Dependent Claim
18 words
Test strip as claimed in claim 1, wherein the carrier is an absorbent material impregnated with the reagents.
Claim 23
Dependent Claim
19 words
Test strip as claimed in claim 1, wherein the carrier is a water-stable film with the reagents incorporated therein.
Claim 24
Dependent Claim
26 words
Test strip as claimed in claim 1, wherein the reagent solution used for the production thereof contains 0.05-1 percent of activator per 100 ml. of solution.
Claim 25
Dependent Claim
26 words
Test strip as claimed in claim 1, wherein the reagent solution used for the production thereof contains 0.2-0.5 percent of activator per 100 ml. of solution.
Claim 26
Dependent Claim
26 words
Test strip as claimed in claim 1, wherein the reagent solution used for the production thereof contains 0.05-5 g. of chromogen per 100 ml. of solution.
Claim 27
Dependent Claim
26 words
Test strip as claimed in claim 1, wherein the reagent solution used for the production thereof contains 0.2-1.0 g. of chromogen per 100 ml. of solution.
Claim 28
Dependent Claim
30 words
Test strip as claimed in claim 1, wherein the reagent solution used for the production thereof contains a buffer and or a complex former, a thickener or a wetting agent.
Claim 29
Dependent Claim
50 words
Method of detecting small amounts of blood in a body fluid which method comprises contacting a test sample of the body fluid with a test strip as claimed in claim 1 and observing the color formation thereon as an indication of the absence or presence of blood in said saple.
Claim 30
Dependent Claim
54 words
Method of detecting small amounts of peroxidatively active substances in a body fluid which method comprises contacting a test sample of the body fluid with a test strip as claimed in claim 1 and observing the color formation thereon as an indication of the absence or presence of peroxidatively active substances in said sample.
References Cited (Backward Citations)
US3290117A
Cited
US3712853A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-09 | 1978-06-10 | 1978-12-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-09 | 1982-06-10 | 1982-12-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-09 | 1986-06-10 | 1986-12-10 | $7700.00 | Window Closed / Lapsed |