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US3985779A
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M-phenoxyphenyl propionic acid derivatives and preparation thereof
Assignee: Eisai Co Ltd
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Filing: 1974-10-29
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Granted: 1976-10-12
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Expires: 1994-10-29
Abstract
Abstract New meta-phenoxyphenyl propionic acid derivatives and pharmacologically acceptable salts thereof having excellent anti-inflammatory and analgesic activities with low toxicity are provided. The new compounds are adapted for therapeutical treatment of various inflammatory diseases by oral administration without injurious by-effects; successive administrations for an elongated period are not accompanied with an appreciable gastric irritability and the like.
Inventors
- 👤 Satoru Tanaka
- 👤 Kazunori Hashimoto
- 👤 Hideaki Watanabe
- 👤 Keiichi Munakata
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 08:55
CPC Classifications
C; C07; C07D; C07D303/00; C07D303/02; C07D303/48; C07C; C07C45/00; C07C45/56; C07C45/57; C07C45/58; C07C45/61; C07C45/67; C07C45/68; C07C45/70; C07C45/71; C07C51/00; C07C51/16
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
65 words
A 2-(m-phenoxyphenyl)propionic acid derivative represented by the formula: ##SPC19## wherein R 1 and R 2 are hydrogen or halogen atoms, or trifluoromethyl, lower alkyl or lower alkoxy groups with the proviso that there is no case where both R 1 and R 2 are simultaneously hydrogen atoms, and pharmacologically acceptable metal salts thereof selected from the group consisting of sodium, potassium, magnesium, calcium and aluminum.
Claim 2
Dependent Claim
65 words
A 2-(m-phenoxyphenyl)propionic acid derivative represented by the formula: ##SPC19## wherein R 1 and R 2 are hydrogen or halogen atoms, or trifluoromethyl, lower alkyl or lower alkoxy groups with the proviso that there is no case where both R 1 and R 2 are simultaneously hydrogen atoms, and pharmacologically acceptable metal salts thereof selected from the group consisting of sodium, potassium, magnesium, calcium and aluminum.
Claim 3
Dependent Claim
32 words
A 2-[m-(o-halophenoxy)phenyl]propionic acid represented by the formula: ##SPC20## wherein Hal is a halogen atom, and pharmacologically acceptable metal salts thereof selected from the group consisting of sodium, potassium, magnesium, calcium and aluminum.
Claim 4
Dependent Claim
32 words
A 2-[m-(o-halophenoxy)phenyl]propionic acid represented by the formula: ##SPC20## wherein Hal is a halogen atom, and pharmacologically acceptable metal salts thereof selected from the group consisting of sodium, potassium, magnesium, calcium and aluminum.
Claim 5
Dependent Claim
32 words
A 2-[m-(p-halophenoxy)phenyl]propionic acid represented by the formula: ##SPC21## wherein Hal is a halogen atom, and pharmacologically acceptable metal salts thereof selected from the group consisting of sodium, potassium, magnesium, calcium and aluminum.
Claim 6
Dependent Claim
32 words
A 2-[m-(p-halophenoxy)phenyl]propionic acid represented by the formula: ##SPC21## wherein Hal is a halogen atom, and pharmacologically acceptable metal salts thereof selected from the group consisting of sodium, potassium, magnesium, calcium and aluminum.
Claim 7
Dependent Claim
31 words
A compound as claimed in claim 1 wherein said compound is 2-[m-(o-chlorophenoxy)phenyl]propionic acid and pharmacologically acceptable metal salts thereof selected from the group consisting of sodium, potassium, magnesium, calcium and aluminum.
Claim 8
Dependent Claim
32 words
A compound as claimed in claim 1 wherein said compound is 2-[m-(o-fluorophenoxy)phenyl] propionic acid and pharmacologically acceptable metal salts thereof selected from the group consisting of sodium, potassium, magnesium, calcium and aluminum.
Claim 9
Dependent Claim
32 words
A compound as claimed in claim 1 wherein said compound is 2-[m-(p-chlorophenoxy)phenyl] propionic acid and pharmacologically acceptable metal salts thereof selected from the group consisting of sodium, potassium, magnesium, calcium and aluminum.
Claim 10
Dependent Claim
30 words
A compound as claimed in claim 1, wherein said compound is the aluminum salt of 2-[m-(o-chlorophenoxy)phenyl] propionic acid, which is produced by adding an aluminum alkoxide to the corresponding acid.
Claim 11
Dependent Claim
30 words
A compound as claimed in claim 1, wherein said compound is the aluminum salt of 2-[m-(o-fluorophenoxy)phenyl] propionic acid, which is produced by adding an aluminum alkoxide to the corresponding acid.
Claim 12
Dependent Claim
30 words
A compound as claimed in claim 1 wherein said compound is the aluminum salt of 2-[m-(p-chlorophenoxy)phenyl] propionic acid, which is produced by adding an aluminum alkoxide to the corresponding acid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-12 | 1980-04-12 | 1980-10-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-12 | 1984-04-12 | 1984-10-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-12 | 1988-04-12 | 1988-10-12 | $7700.00 | Window Closed / Lapsed |