Patent US3985768A successfully refreshed from Google Patents.
US3985768A
Expired / Lapsed
US
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Process for producing rolitetracycline
Assignee: ER Squibb and Sons LLC
•
Filing: 1975-01-23
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Granted: 1976-10-12
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Expires: 1995-01-23
Abstract
Abstract Rolitetracycline is prepared by a process which comprises reacting tetracycline with methylene-bis-pyrrolidine and formaldehyde or paraformaldehyde.
Inventors
- 👤 Horacio Alfredo Priestap
- 👤 Carlos Rappaport
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 03:44
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/12
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
27 words
A process for the production of rolitetracycline which comprises reacting preformed methylene-bis-pyrrolidine with tetracycline and formaldehyde or paraformaldehyde at about ambient temperature in an inert organic solvent.
Claim 2
Dependent Claim
27 words
A process for the production of rolitetracycline which comprises reacting preformed methylene-bis-pyrrolidine with tetracycline and formaldehyde or paraformaldehyde at about ambient temperature in an inert organic solvent.
Claim 3
Dependent Claim
12 words
A process as in claim 1 wherein the solvent is methylene chloride.
Claim 4
Dependent Claim
34 words
A process for the production of rolitetracycline which comprises adding preformed methylene-bis-pyrrolidine to tetracycline and formaldehyde in an inert organic solvent at about 20° to 25° C and removing rolitetracycline from the reaction mixture.
Claim 5
Dependent Claim
34 words
A process for the production of rolitetracycline which comprises adding preformed methylene-bis-pyrrolidine to tetracycline and formaldehyde in an inert organic solvent at about 20° to 25° C and removing rolitetracycline from the reaction mixture.
Claim 6
Dependent Claim
12 words
A process as in claim 3 wherein the solvent is methylene chloride.
Claim 7
Dependent Claim
14 words
A process as in claim 4 wherein the process is effeced under sterile conditions.
Claim 8
Dependent Claim
52 words
A process for the production of rolitetracycline which comprises reacting formaldehyde or paraformaldehyde with pyrrolidine by heating in an inert organic solvent at a temperature up to about reflux temperature, separating methylene-bis-pyrrolidine therefrom, adding said methylene-bis-pyrrolidine to a mixture of tetracycline base and formaldehyde in an inert organic solvent, and separating rolitetracycline.
Claim 9
Dependent Claim
52 words
A process for the production of rolitetracycline which comprises reacting formaldehyde or paraformaldehyde with pyrrolidine by heating in an inert organic solvent at a temperature up to about reflux temperature, separating methylene-bis-pyrrolidine therefrom, adding said methylene-bis-pyrrolidine to a mixture of tetracycline base and formaldehyde in an inert organic solvent, and separating rolitetracycline.
Claim 10
Dependent Claim
11 words
A process as in claim 6 wherein the solvent is ethanol.
Claim 11
Dependent Claim
12 words
A process as in claim 6 wherein the solvent is methylene chloride.
References Cited (Backward Citations)
US3104240A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-12 | 1980-04-12 | 1980-10-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-12 | 1984-04-12 | 1984-10-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-12 | 1988-04-12 | 1988-10-12 | $7700.00 | Window Closed / Lapsed |