US3984543A
Expired / Lapsed
US
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Therapeutic methods employing cyclic aminophosphonic acids
Assignee: Henkel AG and Co KGaA
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Filing: 1975-08-01
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Granted: 1976-10-05
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Expires: 1995-08-01
Abstract
Abstract Therapeutic methods employing cyclic aminophosphonic acids having the formula ##EQU1## wherein R is a member selected from the group consisting of hydrogen and alkyl having from 1 to 6 carbon atoms and n is an integer from 1 to 4; as well as their water-soluble salts. The cyclic aminophosphonic acids are excellent sequestering agents especially for alkaline earth metal ions, useful in cosmetic preparations such as toothpastes and mouthwashes where they prevent formation of tartar and plaque and in therapy in the treatment of diseases related to the abnormal deposition or dissolution of difficulty soluble calcium salts in the animal body.
Inventors
- 👤 Walter Ploger
- 👤 Manfred Schmidt-Dunker
- 👤 Christian Gloxhuber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 19:16
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6564; C07F9/6581; C07F9/6584; A; A61; A61K; A61K31/00; A61K31/66; A61K31/675; A61K8/00; A61K8/18; A61K8/30; A61K8/55; A61Q; A61Q11/00; C02; C02F; C02F5/00; C02F5/08; C02F5/10; C02F5/14; C07F9/28; C07F9/38; C07F9/3804; C07F9/3839; C07F9/3873
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
114 words
A method for alleviating conditions caused by the abnormal deposition or dissolution of difficultly soluble calcium salts in the body of warm-blooded animals having said condition which consists of administering to said warm-blooded animals a safe but effective amount for said treatment of from 0.05 to 500 mg per kg of the body weight of a pharmacologically acceptable cyclic aminophosphonic acid derivative selected from the group consisting of (1) a compound of the formula ##EQU2## wherein R is a member selected from the group consisting of hydrogen and alkyl having from 1 to 6 carbon atoms and n is an integer from 1 to 3, and (2) a non-toxic pharmacologically acceptable water-soluble salt thereof.
Claim 2
Independent Claim
114 words
A method for alleviating conditions caused by the abnormal deposition or dissolution of difficultly soluble calcium salts in the body of warm-blooded animals having said condition which consists of administering to said warm-blooded animals a safe but effective amount for said treatment of from 0.05 to 500 mg per kg of the body weight of a pharmacologically acceptable cyclic aminophosphonic acid derivative selected from the group consisting of (1) a compound of the formula ##EQU2## wherein R is a member selected from the group consisting of hydrogen and alkyl having from 1 to 6 carbon atoms and n is an integer from 1 to 3, and (2) a non-toxic pharmacologically acceptable water-soluble salt thereof.
Claim 3
Dependent Claim
13 words
The method of claim 1 wherein n is 1 and R is hydrogen.
Claim 4
Dependent Claim
13 words
The method of claim 1 wherein n is 2 and R is hydrogen.
Claim 5
Dependent Claim
13 words
The method of claim 1 wherein n is 2 and R is methyl.
Claim 6
Dependent Claim
13 words
The method of claim 1 wherein n is 2 and R is ethyl.
Claim 7
Dependent Claim
13 words
The method of claim 1 wherein n is 2 and R is n-butyl.
Claim 8
Dependent Claim
13 words
The method of claim 1 wherein n is 3 and R is hydrogen.
Claim 9
Dependent Claim
13 words
The method of claim 1 wherein n is 3 and R is methyl.
Claim 10
Dependent Claim
21 words
The method of claim 1 wherein said water-soluble salt is selected from the group consisting of alkali metal and ammonium salts.
References Cited (Backward Citations)
US3678164A
Cited
US3719756A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-05 | 1980-04-05 | 1980-10-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-05 | 1984-04-05 | 1984-10-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-05 | 1988-04-05 | 1988-10-05 | $7700.00 | Window Closed / Lapsed |