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Patent US3984436A successfully refreshed from Google Patents.
US3984436A
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Pyrrolyl compounds and processes for their manufacture
Assignee: Novartis Corp
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Filing: 1974-02-28
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Granted: 1976-10-05
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Expires: 1994-02-28
Abstract
Abstract Pyrrolyl compounds of the formula I ##EQU1## wherein Py is optionally lower-alkylated 1-pyrrolyl, Ph is phenylene, R 1 is hydrogen or lower alkyl and R 2 is hydrogen, lower alkyl, aryl-lower alkyl or optionally functionally modified carboxy-lower alkyl or R 1 and R 2 together are lower alkylene, oxa-lower alkylene, thia-lower alkylene or aza-lower alkylene, their antipodes and salts, which are valuable blockers of adrenergic β-receptors.
Inventors
- 👤 Knut A. Jaeggi
- 👤 Franz Ostermayer
- 👤 Herbert Schroter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 09:31
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/30; C07D207/32; C07D207/325; A; A61; A61P; A61P25/00; A61P25/02; A61P9/00; A61P9/06; A61P9/08; A61P9/10
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
72 words
Pyrrolyl compounds of the formula I ##EQU2## wherein Py is 1-pyrrolyl or mono- or di-lower alkylated 1-pyrrolyl, Ph is phenylene, R 1 is hydrogen or lower alkyl and R 2 is hydrogen, lower alkyl, phenyl-lower alkyl having up to 10 carbon atoms wherein the phenyl ring is unsubstituted or mono-substituted by lower alkyl, lower alkoxy, halogen or trifluoromethyl, or R 1 and R 2 together are lower alkylene, their antipodes and salts.
Claim 2
Dependent Claim
72 words
Pyrrolyl compounds of the formula I ##EQU2## wherein Py is 1-pyrrolyl or mono- or di-lower alkylated 1-pyrrolyl, Ph is phenylene, R 1 is hydrogen or lower alkyl and R 2 is hydrogen, lower alkyl, phenyl-lower alkyl having up to 10 carbon atoms wherein the phenyl ring is unsubstituted or mono-substituted by lower alkyl, lower alkoxy, halogen or trifluoromethyl, or R 1 and R 2 together are lower alkylene, their antipodes and salts.
Claim 3
Dependent Claim
34 words
Pyrrolyl compounds of the formula I Py-Ph-O-CH.sub.2 -CHOH-CH.sub.2 -NH-R.sub.2 (I) wherein Py is 1-pyrrolyl or mono- or di-lower alkylated 1-pyrrolyl, Ph is phenylene and R 2 is lower alkyl, their optical antipodes and salts.
Claim 4
Dependent Claim
34 words
Pyrrolyl compounds of the formula I Py-Ph-O-CH.sub.2 -CHOH-CH.sub.2 -NH-R.sub.2 (I) wherein Py is 1-pyrrolyl or mono- or di-lower alkylated 1-pyrrolyl, Ph is phenylene and R 2 is lower alkyl, their optical antipodes and salts.
Claim 5
Dependent Claim
31 words
A compound as claimed in claim 2 having the formula I wherein Py is 1-pyrrolyl or 2,5-dimethyl-1-pyrrolyl, Ph is phenylene and R 2 is lower alkyl, their optical antipodes and salts.
Claim 6
Dependent Claim
33 words
A compound as claimed in claim 2 having the formula I wherein Py is 1-pyrrolyl or 2,5-dimethyl-1-pyrrolyl, Ph is ortho- or para-phenylene and R 2 is lower alkyl, their optical antipodes and salts.
Claim 7
Dependent Claim
36 words
A compound as claimed in claim 2 having the formula I wherein Py is 1-pyrrolyl or 2,5-dimethyl-1-pyrrolyl, Ph is ortho- or para-phenylene and R 2 is methyl, ethyl, isopropyl or tert.-butyl, their optical antipodes and salts.
Claim 8
Dependent Claim
19 words
A compound as claimed in claim 2 having the formula I which is 1-[4-pyrrolyl-(1)-phenoxy]-2-hydroxy-3-isopropylamino-propane, its optical antipodes and salts.
Claim 9
Dependent Claim
9 words
The hydrochloride salt of the compound of claim 6.
Claim 10
Dependent Claim
19 words
A compound as claimed in claim 2 having the formula I which is 1-[2-pyrrolyl-(1)-phenoxy]-2-hydroxy-3-isopropylamino-propane, its optical antipodes and salts.
Claim 11
Dependent Claim
9 words
The hydrochloride salt of the compound of claim 8.
Claim 12
Dependent Claim
19 words
A compound as claimed in claim 2 having the formula I which is 1-tert.-butylamino-3-[o-pyrrol-1-yl)-phenoxy]-2-propanol, its optical antipodes and salts.
Claim 13
Dependent Claim
10 words
The neutral fumarate salt of the compound of claim 10.
Claim 14
Dependent Claim
19 words
A compound as claimed in claim 9 having the formula I which is 1-[o-(2,5-dimethyl-pyrrol-1-yl)-phenoxy]-3-isopropylamino-2-propanol, its optical antipodes and salts.
Claim 15
Dependent Claim
10 words
The neutral fumarate salt of the compound of claim 2.
References Cited (Backward Citations)
US3328417A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-05 | 1980-04-05 | 1980-10-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-05 | 1984-04-05 | 1984-10-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-05 | 1988-04-05 | 1988-10-05 | $7700.00 | Window Closed / Lapsed |