Pharmaceutically effective novel 3,4-dihydro-1,2- and 1,3-thiozolo [4,3a] is

Abstract

Abstract The invention relates to new thiazoloisoquinolines of the general formula (I), or salts thereof, ##SPC1## Wherein A stands for a group of the formula ##EQU1## R 1 stands for hydrogen, hydroxy, alkoxy or aralkoxy, R 2 stands for hydrogen, hydroxy, alkoxy or aralkoxy, R 3 stands for hydrogen, alkyl, aryl, nitro, carboxy or a carboxy derivative, and Y stands for oxygen, sulfur, or a group of the formula =N--R 4 , wherein R 4 stands for hydrogen, alkyl, aryl, acyl, alkylsulfonyl or arylsulfonyl. These new compounds can be used in practice as heart medicines or respiratory analeptics. The new compounds according to the invention can be prepared as follows: an isoquinoline of the general formula (II) or a salt thereof ##SPC2## Wherein R 5 stands for hydrogen, hydroxy, alkoxy or aralkoxy, R 6 stands for hydrogen, hydroxy, alkoxy or aralkoxy, R 7 stands for hydrogen, alkyl, aryl, carboxy or a carboxy derivative, and X stands for hydrogen, halogen or mercapto, Is reacted with a reactive carbonic acid derivative, provided that at least one of the reactants contains a sulfur atom, and/or an isoquinoline of the general formula (III) ##SPC3## wherein R 5 , R 6 and R 7 each have the same meanings as defined above, and Y' stands for oxygen, sulfur or a group of the formula =N--R.sup. 8, wherein R 8 represents hydrogen, alkyl, aryl, acyl, arylsulfonyl or alkylsulfonyl, is oxidized, and/or substituents A', R 5 , R 6 and R 7 of the obtained thiazoloisoquinoline of the general formula (IA) ##SPC4## wherein A' stands for a group of the formula ##EQU2## and R 5 , R 6 , R 7 and Y' each have the same meanings as defined above, are converted into those required in the end-products.

Inventors

• 👤 Kalman Harsanyi
• 👤 Kalman Takacs
• 👤 Pal Kiss
• 👤 Laszlo Szekeres
• 👤 Gyula Papp
• 👤 Eva Benedek

Bibliographic Details