Patent US3976787A successfully refreshed from Google Patents.
US3976787A
Expired / Lapsed
US
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Pharmaceutical guanidine preparations and methods of using same
Assignee: Armour Pharmaceutical Co
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Filing: 1975-03-06
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Granted: 1976-08-24
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Expires: 1995-03-06
Abstract
Abstract Pharmaceutical preparations and methods of using the same to treat a host having a condition requiring vasoconstrictive therapy. The preparations comprise a pharmaceutically acceptable carrier and a guanidine compound, or non-toxic acid addition salt thereof, having the structural notation: ##SPC1## Wherein: R 1 is hydrogen or alkyl having 1-4 carbon atoms; R 2 is hydrogen, hydroxy, chloro, fluoro or bromo; and R 3 is hydrogen or the same as R 2 when R 2 is chloro, bromo or fluoro.
Inventors
- 👤 John Lawrence Hughes
- 👤 Robert Chung-Huan Liu
- 👤 Takashi Enkoji
- 👤 James Winslow Bastian
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 18:31
CPC Classifications
C; C07; C07C; C07C279/00; C07C279/18
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
72 words
A pharmaceutical preparation for providing vasoconstrictive therapy comprising a pharmaceutically acceptable carrier and an effective amount of a phenylguanidine compound, or a non-toxic acid addition salt thereof, said compound having the formula: ##SPC3## wherein: R 1 is hydrogen and R 2 and R 3 are chloro; or R 1 and R 4 are hydrogen and R 3 is hydroxy; or R 1 is methyl and R 2 and R 3 are hydrogen.
Claim 2
Dependent Claim
72 words
A pharmaceutical preparation for providing vasoconstrictive therapy comprising a pharmaceutically acceptable carrier and an effective amount of a phenylguanidine compound, or a non-toxic acid addition salt thereof, said compound having the formula: ##SPC3## wherein: R 1 is hydrogen and R 2 and R 3 are chloro; or R 1 and R 4 are hydrogen and R 3 is hydroxy; or R 1 is methyl and R 2 and R 3 are hydrogen.
Claim 3
Dependent Claim
14 words
A preparation according to claim 1 in which said compound is denominated 3',4'-dichlorophenyl guanidine.
Claim 4
Dependent Claim
14 words
A preparation according to claim 1 in which said compound is denominated 3'-hydroxyphenyl guanidine.
Claim 5
Dependent Claim
16 words
A preparation according to claim 1 in which said acid addition salt is 3',4'-dichlorophenyl guanidine hydrochloride.
Claim 6
Dependent Claim
16 words
A preparation according to claim 1 in which said acid addition salt is 3'-hydroxyphenyl guanidine hydrochloride.
Claim 7
Dependent Claim
13 words
A preparation according to claim 1 in which said compound is 2'-methylphenyl guanidine.
Claim 8
Dependent Claim
40 words
A pharmaceutical preparation according to claim 1 in a unit dosage form selected from the group consisting of a tablet, a capsule, a packet, a lozenge, a glosset, a sterile solution, a suspension, an emulsion, an ointment, and a suppository.
Claim 9
Independent Claim
101 words
A method of producing vasoconstriction in a host in need thereof which comprises administering to said host a sufficient amount of a phenylguanidine compound, or a non-toxic acid addition salt thereof, to provide said host a dose of the said compound of from about 1 mg. to about 5 mg. per kilogram of host body weight, said compound having the formula: ##SPC4## wherein: R 1 is hydrogen or alkyl having 1-4 carbon atoms; R 2 is hydrogen, hydroxy, chloro, fluoro or bromo; and R 3 is hydrogen or the same as R 2 when R 2 is chloro, bromo or fluoro.
Claim 10
Independent Claim
101 words
A method of producing vasoconstriction in a host in need thereof which comprises administering to said host a sufficient amount of a phenylguanidine compound, or a non-toxic acid addition salt thereof, to provide said host a dose of the said compound of from about 1 mg. to about 5 mg. per kilogram of host body weight, said compound having the formula: ##SPC4## wherein: R 1 is hydrogen or alkyl having 1-4 carbon atoms; R 2 is hydrogen, hydroxy, chloro, fluoro or bromo; and R 3 is hydrogen or the same as R 2 when R 2 is chloro, bromo or fluoro.
Claim 11
Dependent Claim
14 words
A method according to claim 8 in which said guanidine is denominated 3',4'-dichlorophenyl guanidine.
Claim 12
Dependent Claim
14 words
A method according to claim 8 in which said guanidine is denominated 3'-hydroxyphenyl guanidine.
Claim 13
Dependent Claim
16 words
A method according to claim 8 in which said guanidine is delivered as a hydrochloride salt.
Claim 14
Dependent Claim
13 words
A method according to claim 8 in which said compound is 2'-methylphenyl guanidine.
References Cited (Backward Citations)
US3681459A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-08-24 | 1980-02-23 | 1980-08-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-08-24 | 1984-02-23 | 1984-08-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-08-24 | 1988-02-23 | 1988-08-24 | $7700.00 | Window Closed / Lapsed |