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US3976780A
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Methods of protection against emesis in mammals by administration of a 3-alkoxy-thianaphthene-2-carboxamide
Assignee: Societe dEtudes Scientifiques et Industrielles de lIle de France SA
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Filing: 1975-01-06
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Granted: 1976-08-24
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Expires: 1995-01-06
Abstract
Abstract Emesis in mammals is prevented by administration of 3-alkoxy-thianaphthene-2-carboxamides in a daily dosage ranging from 50 to 500 μg/kg as determined by a physician or veterinarian. When administered to dogs in a daily dosage of 250 μg/kg, 100% protection is obtained against vomiting normally induced by subcutaneous administration of apomorphine.
Inventors
- 👤 Michel Leon Thominet
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 16:48
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/40; C; C07; C07D; C07D333/00; C07D333/50; C07D333/52; C07D333/62; C07D333/68; C07D333/70
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
92 words
A method of protecting a mammal against emesis which comprises administering to said mammal an anti-emesis effective amount of a compound selected from the group consisting of a 3-alkoxy-thianaphthene-2-carboxamide, the dioxides thereof, the pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof, said 3-alkoxy-thianaphthene-2-carboxamide having the formula: ##SPC5## in which R 1 and R 2 are the same or different and are hydrogen, lower alkoxy, halogen, nitro or amino; B is lower alkyl or allyl; n is 1, 2 or 3; and A is mono lower alkylamino or di lower alkylamino.
Claim 2
Independent Claim
92 words
A method of protecting a mammal against emesis which comprises administering to said mammal an anti-emesis effective amount of a compound selected from the group consisting of a 3-alkoxy-thianaphthene-2-carboxamide, the dioxides thereof, the pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof, said 3-alkoxy-thianaphthene-2-carboxamide having the formula: ##SPC5## in which R 1 and R 2 are the same or different and are hydrogen, lower alkoxy, halogen, nitro or amino; B is lower alkyl or allyl; n is 1, 2 or 3; and A is mono lower alkylamino or di lower alkylamino.
Claim 3
Dependent Claim
20 words
The method of claim 1 in which said compound is a compound in which A of the formula is diethylamino.
Claim 4
Dependent Claim
20 words
The method of claim 1 in which said compound is a compound in which A of the formula is dimethylamino.
Claim 5
Dependent Claim
11 words
The method of claim 1 in which said compound is N-(diethylaminoethyl)-3-methoxy-thianaphthene-2-carboxamide.
Claim 6
Dependent Claim
11 words
The method of claim 1 in which said compound is N-(diethylaminoethyl)-3-methoxy-5-amino-thianaphthene-2-carboxamide.
Claim 7
Dependent Claim
11 words
The method of claim 1 in which said compound is N-(dimethylaminoethyl)-3-5-6-trimethoxy-thianaphthene-2-carboxamide.
Claim 8
Dependent Claim
11 words
The method of claim 1 in which said compound is N-(diethylaminoethyl)-1,1-dioxy-3-methoxy-thianaphthene-2-carboxamide.
Claim 9
Dependent Claim
16 words
The method of claim 1 in which said compound is a levo or dextro rotary isomer.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-08-24 | 1980-02-23 | 1980-08-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-08-24 | 1984-02-23 | 1984-08-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-08-24 | 1988-02-23 | 1988-08-24 | $7700.00 | Window Closed / Lapsed |