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US3976770A
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Sar'-(OMe)Thr8 Angiotensin II as an angiotensin II antagonist
Assignee: Individual
•
Filing: 1975-02-10
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Granted: 1976-08-24
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Expires: 1995-02-10
Abstract
Abstract A new octapeptide having profound angiotensin antagonist properties has been found. The new compound resembles angiotensin II except for the two terminal amino acids, carrying unnatural amino acids at the N-terminus, and at the C-terminus.
Inventors
- 👤 Francis Merlin Bumpus
- 👤 Mahesh Chandra Khosla
- 👤 Robert Rudolph Smeby
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:16
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/14; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
4 words
The octapeptide Sar-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro- -(OMe)Thr.
Claim 2
Dependent Claim
4 words
The octapeptide Sar-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro- -(OMe)Thr.
Claim 3
Dependent Claim
47 words
A composition suitable for parenteral administration to a warm-blooded animal consisting essentially of the octapeptide of claim 1 dissolved in a liquid, pharmaceutically acceptable vehicle suitable for injection into warm-blooded animals, said octapeptide being present at a concentration of between 50 and 6000 ng/ml of said vehicle.
Claim 4
Dependent Claim
19 words
The composition of of claim 2 wherein said vehicle is water buffered to a pH of 7 to 7.5.
Claim 5
Dependent Claim
12 words
The composition of claim 2 wherein said vehicle is an oil solution.
References Cited (Backward Citations)
US3886134A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-08-24 | 1980-02-23 | 1980-08-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-08-24 | 1984-02-23 | 1984-08-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-08-24 | 1988-02-23 | 1988-08-24 | $7700.00 | Window Closed / Lapsed |