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Aluminum salts of substituted phenylalkanoic acids

Assignee: Eli Lilly and Co
•
Filing: 1974-05-13
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Granted: 1976-08-24
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Expires: 1994-05-13
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Abstract

Abstract Novel Mono- and di-basic aluminum salts of 2-(3-phenoxyphenyl)-and 2-(3-phenylthiophenyl)alkanoic acids provide tasteless and practically water insoluble forms of said alkanoic acids, which have anti-inflammatory activity in mammals, for formulating pharmaceutical suspensions.

Inventors

  • 👤 Calvin H. Fields
  • 👤 Clarence A. Hirsch

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-24 22:49
CPC Classifications
C; C07; C07F; C07F5/00; C07F5/06; C07F5/069; C07C; C07C323/00

Claims Analysis

Total Claims: 6
Claim 1
Independent Claim 96 words
A compound of the formula: (R.sub.1).sub.n -Al-(OH).sub.3-n wherein: n is 1 or 2; and R 1 is the moiety ##SPC2## wherein: p is 0, 1, 2, or 3; X is oxygen or sulfur; R 2 is hydrogen, C 1 -C 5 alkyl, C 2 -C 5 alkenyl, C 2 -C 5 alkynyl, or C 3 -C 6 cycloalkyl; and Y 1 and Y 2 are, independently, hydrogen, hydroxy, halo, C 1 -C 3 alkyl, or C 1 -C 3 alkoxy, but Y 2 is hydrogen when Y 1 is hydroxy or C 1 -C 3 alkoxy.
Claim 2
Dependent Claim 96 words
A compound of the formula: (R.sub.1).sub.n -Al-(OH).sub.3-n wherein: n is 1 or 2; and R 1 is the moiety ##SPC2## wherein: p is 0, 1, 2, or 3; X is oxygen or sulfur; R 2 is hydrogen, C 1 -C 5 alkyl, C 2 -C 5 alkenyl, C 2 -C 5 alkynyl, or C 3 -C 6 cycloalkyl; and Y 1 and Y 2 are, independently, hydrogen, hydroxy, halo, C 1 -C 3 alkyl, or C 1 -C 3 alkoxy, but Y 2 is hydrogen when Y 1 is hydroxy or C 1 -C 3 alkoxy.
Claim 3
Dependent Claim 12 words
A compound according to claim 1, said compound being di-[2-(3-phenoxyphenyl)propionoxy] aluminum hydroxide.
Claim 4
Dependent Claim 12 words
A compound according to claim 1, said compound being di-[2-(3-phenoxyphenyl)acetoxy] aluminum hydroxide.
Claim 5
Dependent Claim 12 words
A compound according to claim 1, said compound being 2-(3-phenoxyphenyl)propionoxy aluminum dihydroxide.
Claim 6
Dependent Claim 12 words
A compound according to claim 1, said compound being 2-(3-phenoxyphenyl)acetoxy aluminum dihydroxide.

References Cited (Backward Citations)

US3517051A Cited
US3600437A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1979-08-24 1980-02-23 1980-08-24 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1983-08-24 1984-02-23 1984-08-24 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1987-08-24 1988-02-23 1988-08-24 $7700.00 Window Closed / Lapsed

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