Patent US3976639A successfully refreshed from Google Patents.
US3976639A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Intermediates for indoles
Assignee: Hoffmann La Roche Inc
•
Filing: 1975-03-31
•
Granted: 1976-08-24
•
Expires: 1995-03-31
Abstract
Abstract Ortho-nitrotoluenes are condensed with formamide acetals to yield the corresponding otho-nitro-β-aminestyrenes which undergo cyclization upon reduction to yield indoles.
Inventors
- 👤 Andrew David Batcho
- 👤 Willy Leimgruber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 13:23
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/04; C07D209/08
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
65 words
A compound of the formula ##SPC5## wherein R 1 ' is hydrogen, lower alkoxy, formyl, phenyl-lower alkoxy, halogen or di-lower alkoxymethyl, R 2 ' is lower alkoxy, formyl, phenyl-lower alkoxy, halogen or di-lower alkoxymethyl, and when taken together, R 1 ' and R 2 ' are methylenedioxy; R 7 and R 8 , independently, are lower alkyl, and when taken together, are piperidino or pyrrolidino.
Claim 2
Dependent Claim
65 words
A compound of the formula ##SPC5## wherein R 1 ' is hydrogen, lower alkoxy, formyl, phenyl-lower alkoxy, halogen or di-lower alkoxymethyl, R 2 ' is lower alkoxy, formyl, phenyl-lower alkoxy, halogen or di-lower alkoxymethyl, and when taken together, R 1 ' and R 2 ' are methylenedioxy; R 7 and R 8 , independently, are lower alkyl, and when taken together, are piperidino or pyrrolidino.
Claim 3
Dependent Claim
20 words
A compound in accordance with claim 1, wherein R 1 ' is hydrogen and R 2 ' is lower alkoxy.
Claim 4
Dependent Claim
8 words
A compound in accordance with claim 2, trans-β-dimethylamino-4-methoxy-2-nitrostyrene.
Claim 5
Dependent Claim
20 words
A compound in accordance with claim 1, wherein R 1 ' is hydrogen and R 2 ' is phenyl-lower alkoxy.
Claim 6
Dependent Claim
8 words
A compound in accordance with claim 4, trans-5-benzyloxy-β-dimethylamino-2-nitrostyrene.
Claim 7
Dependent Claim
19 words
A compound in accordance with claim 1, wherein R 1 ' is hydrogen and R 2 ' is halogen.
Claim 8
Dependent Claim
8 words
A compound in accordance with claim 6, trans-5-chloro-β-dimethylamino-2-nitrostyrene.
Claim 9
Dependent Claim
8 words
A compound in accordance with claim 1, trans-2-nitro-β-piperidinostyrene.
Claim 10
Dependent Claim
8 words
A compound in accordance with claim 1, trans-2-nitro-β-pyrrolidinostyrene.
Claim 11
Dependent Claim
8 words
A compound in accordance with claim 1, trans-β-dimethylamino-4,5-dimethoxy-2-nitrostyrene.
Claim 12
Dependent Claim
8 words
A compound in accordance with claim 1, trans-4,5-dibenzyloxy-β-dimethylamino-2-nitrostyrene.
Claim 13
Dependent Claim
8 words
A compound in accordance with claim 1, trans-β-dimethylamino-4,5-methylenedioxy-2-nitrostyrene.
Claim 14
Dependent Claim
8 words
A compound in accordance with claim 1, trans-4-(β-dimethylamino-vinyl)-3-nitrobenzaldehyde.
Claim 15
Dependent Claim
9 words
A compound in accordance with claim 1, trans-4-(β-dimethylamino-vinyl)-3-nitrobenzaldehyde dimethylacetal.
References Cited (Backward Citations)
US3530120A
Cited
US3732245A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-08-24 | 1980-02-23 | 1980-08-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-08-24 | 1984-02-23 | 1984-08-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-08-24 | 1988-02-23 | 1988-08-24 | $7700.00 | Window Closed / Lapsed |