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US3974272A
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Palatable cholestyramine coacervate compositions
Assignee: Merck and Co Inc
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Filing: 1974-01-25
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Granted: 1976-08-10
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Expires: 1994-01-25
Abstract
Abstract Palatable oral coacervate compositions containing Cholestyramine and a Modified Gum selected from the group consisting of hydrophilic colloid of cellulosive material and charged anionic gum in an aqueous medium.
Inventors
- 👤 Gerald P. Polli
- 👤 Clyde E. Shoop
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 05:11
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0087; A61K9/0095; A61K31/00; A61K31/74; A61K31/785; A61K47/00; A61K47/30; A61K47/36; A61K47/38; A61K9/20; A61K9/2004
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
145 words
An oral palatable composition comprising an aqueous medium selected from the group consisting of water, milk and fruit juice; a modified gum selected from the group consisting of hydrophilic colloid of cellulosive material and charged anionic gum wherein the hydrophilic colloid of cellulosive material is selected from the group consisting of methyl cellulose, ethyl cellulose, sodium carboxymethyl cellulose, hydroxy ethyl cellulose and hydroxypropyl cellulose and the charged anionic gum is selected from the group consisting of carageenan, sodium alginate, potassium alginate and propylene glycol alginate; and an effective amount of cholestyramine, wherein there is present from about 4 to 10 parts of cholestyramine and from about 4 to 10 oz. of the aqueous medium per part of modified gum to the total weight of the formulation and wherein the cholestyramine and the modified gum, in the presence of the aqueous medium, are in coacervate form.
Claim 2
Dependent Claim
145 words
An oral palatable composition comprising an aqueous medium selected from the group consisting of water, milk and fruit juice; a modified gum selected from the group consisting of hydrophilic colloid of cellulosive material and charged anionic gum wherein the hydrophilic colloid of cellulosive material is selected from the group consisting of methyl cellulose, ethyl cellulose, sodium carboxymethyl cellulose, hydroxy ethyl cellulose and hydroxypropyl cellulose and the charged anionic gum is selected from the group consisting of carageenan, sodium alginate, potassium alginate and propylene glycol alginate; and an effective amount of cholestyramine, wherein there is present from about 4 to 10 parts of cholestyramine and from about 4 to 10 oz. of the aqueous medium per part of modified gum to the total weight of the formulation and wherein the cholestyramine and the modified gum, in the presence of the aqueous medium, are in coacervate form.
Claim 3
Dependent Claim
27 words
The composition of claim 1 wherein there is present 6 to 8 parts of cholestyramine and 5 to 8 oz. aqueous medium per part of modified gum.
Claim 4
Dependent Claim
23 words
The composition of claim 2 wherein the modified gum is hydrophilic colloid of cellulosive material and the aqueous medium is a fruit juice.
Claim 5
Dependent Claim
39 words
The composition of claim 3 wherein the hydrophilic colloid of cellulosive material is sodium carboxymethyl cellulose and the aqueous medium is a fruit juice selected from the group consisting of orange juice, grapefruit juice, tomato juice and pineapple juice.
Claim 6
Dependent Claim
42 words
The composition of claim 1 further comprising a water soluble dispersing agent selected from the group consisting of sucrose, dextrose and a low substituted carboxymethyl starch of the formula: ##SPC2## which ranges from 0.5 to 1.5 parts per part of modified gum.
Claim 7
Dependent Claim
35 words
The composition of claim 5 wherein the water soluble dispersing agent is a low substituted carboxymethyl starch and the modified gum is hydrophilic colloid of cellulosive material and the aqueous medium is a fruit juice.
Claim 8
Dependent Claim
16 words
The composition of claim 6 wherein the hydrophilic colloid of cellulosive material is sodium carboxymethyl cellulose.
Claim 9
Dependent Claim
38 words
The composition of claim 1 further comprising a water insoluble dispersing agent selected from the group consisting of corn starch, dibasic calcium phosphate and potato starch which ranges from 0.5 to 1.5 parts per part of modified gum.
Claim 10
Dependent Claim
31 words
The composition of claim 8 wherein the water insoluble dispersing agent is corn starch, the modified gum is hydrophilic colloid of cellulosive material and the aqueous medium is a fruit juice.
Claim 11
Dependent Claim
16 words
The composition of claim 9 wherein the hydrophilic colloid of cellulosive material is sodium carboxymethyl cellulose.
Claim 12
Independent Claim
168 words
A method of treating a patient suffering from a condition exhibiting at least one of the symptoms of hypocholesteremia and biliary cirrhosis which comprises oral administration of a composition comprising an aqueous medium selected from the group consisting of water, milk, and fruit juice; a modified gum selected from the group consisting of hydrophilic colloid of cellulosive material and charged anionic gum wherein the hydrophilic colloid of cellulosive material is selected from the group consisting of methyl cellulose, ethyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl cellulose and hydroxypropyl cellulose and the charged anionic gum is selected from the group consisting of carrageenan, sodium alginate, potassium alginate and propylene glycol alginate; and an effective amount of cholestyramine, wherein there is present from about 4 to 10 parts of cholestyramine and from about 4 to 10 oz. of aqueous medium per part of modified gum to the total weight of the formulation and wherein the cholestyramine and the modified gum, in the presence of the aqueous medium, are in coacervate form.
Claim 13
Independent Claim
168 words
A method of treating a patient suffering from a condition exhibiting at least one of the symptoms of hypocholesteremia and biliary cirrhosis which comprises oral administration of a composition comprising an aqueous medium selected from the group consisting of water, milk, and fruit juice; a modified gum selected from the group consisting of hydrophilic colloid of cellulosive material and charged anionic gum wherein the hydrophilic colloid of cellulosive material is selected from the group consisting of methyl cellulose, ethyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl cellulose and hydroxypropyl cellulose and the charged anionic gum is selected from the group consisting of carrageenan, sodium alginate, potassium alginate and propylene glycol alginate; and an effective amount of cholestyramine, wherein there is present from about 4 to 10 parts of cholestyramine and from about 4 to 10 oz. of aqueous medium per part of modified gum to the total weight of the formulation and wherein the cholestyramine and the modified gum, in the presence of the aqueous medium, are in coacervate form.
Claim 14
Dependent Claim
27 words
The method of claim 11 wherein there is present 6 to 8 parts of cholestyramine and 5 to 8 oz. aqueous medium per part of modified gum.
Claim 15
Dependent Claim
23 words
The method of claim 12 wherein the modified gum is hydrophilic colloid of cellulosive material and the aqueous medium is a fruit juice.
Claim 16
Dependent Claim
39 words
The method of claim 13 wherein the hydrophilic colloid of cellulosive material is sodium carboxymethyl cellulose and the aqueous medium is a fruit juice selected from the group consisting of orange juice, grapefruit juice, tomato juice and pineapple juice.
Claim 17
Dependent Claim
42 words
The method of claim 11 further comprising a water soluble dispersing agent selected from the group consisting of sucrose, dextrose and a low substituted carboxymethyl starch of the formula: ##SPC3## which ranges from 0.5 to 1.5 part per part of modified gum.
Claim 18
Dependent Claim
34 words
The method of claim 15 wherein the water soluble dispersing agent is a low substituted carboxymethyl starch, the modified gum is hydrophilic colloid of cellulosive material and the aqueous medium is a fruit juice.
Claim 19
Dependent Claim
16 words
The method of claim 16 wherein the hydrophilic colloid of cellulosive material is sodium carboxymethyl cellulose.
Claim 20
Dependent Claim
38 words
The method of claim 11 further comprising a water insoluble dispersing agent selected from the group consisting of corn starch, dibasic calcium phosphate and potato starch which ranges from 0.5 to 1.5 part per part of modified gum.
Claim 21
Dependent Claim
31 words
The method of claim 18 wherein the water insoluble dispersing agent is corn starch, the modified gum is hydrophilic colloid of cellulosive material and the aqueous medium is a fruit juice.
Claim 22
Dependent Claim
16 words
The method of claim 19 wherein the hydrophilic colloid of cellulosive material is sodium carboxymethyl cellulose.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-08-10 | 1980-02-09 | 1980-08-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-08-10 | 1984-02-09 | 1984-08-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-08-10 | 1988-02-09 | 1988-08-10 | $7700.00 | Window Closed / Lapsed |