Patent US3972994A successfully refreshed from Google Patents.
US3972994A
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Disubstituted azabicycloalkanes
Assignee: Science Union et Cie
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Filing: 1974-11-20
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Granted: 1976-08-03
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Expires: 1994-11-20
Abstract
Abstract Disubstituted azabicycloalkanes of the formula ##SPC1## Wherein: n is 0, 1 or 2 R is saturated or unsaturated straight or branched (C 1 -C 5 ) aliphatic hydrocarbon, and X 1 , x 2 , x 3 , x 4 , x 5 , which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl. These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.
Inventors
- 👤 Laszlo Beregi
- 👤 Pierre Hugon
- 👤 Xavier Pascaud
- 👤 Jean-Claude Poignant
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 20:18
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/44; A; A61; A61P; A61P1/00; A61P1/08; A61P9/00; A61P9/12; C07D209/52
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
98 words
A compound selected from the group consisting of: A. disubstituted azabicycloalkanes of the general formula I: ##SPC12## wherein: n is 2; R is selected from the group consisting of saturated and unsaturated aliphatic hydrocarbon having from 1 to 5 carbon atoms inclusive in straight and branched chain, and, X 1 , x 2 , x 3 , x 4 and X 5 are each selected from the group consisting of hydrogen, halogen, hydroxy, alkyl and alkoxy each having from 1 to 5 carbon atoms inclusive, trifluoromethyl, nitro, amino, and sulfamoyl, and, B. physiologically tolerable acid addition salts thereof.
Claim 2
Dependent Claim
98 words
A compound selected from the group consisting of: A. disubstituted azabicycloalkanes of the general formula I: ##SPC12## wherein: n is 2; R is selected from the group consisting of saturated and unsaturated aliphatic hydrocarbon having from 1 to 5 carbon atoms inclusive in straight and branched chain, and, X 1 , x 2 , x 3 , x 4 and X 5 are each selected from the group consisting of hydrogen, halogen, hydroxy, alkyl and alkoxy each having from 1 to 5 carbon atoms inclusive, trifluoromethyl, nitro, amino, and sulfamoyl, and, B. physiologically tolerable acid addition salts thereof.
Claim 3
Dependent Claim
12 words
A compound of claim 1 which is N-ethyl-7-(2-methoxy-5-sulfamoyl benzamido methyl)-8-azabicyclo (4,3,0) nonane.
Claim 4
Dependent Claim
12 words
A compound of claim 1, which is N-ethyl-7-(3-sulfamoyl-4-chloro benzamido methyl)-8-azabicyclo (4,3,0)nonane hydrochloride.
Claim 5
Dependent Claim
13 words
A compound of claim 1, which is N-ethyl-7-(2-methoxy-5-chloro benzamido methyl)-8-azabicyclo (4,3,0) nonane hydrochloride.
Claim 6
Dependent Claim
12 words
A compound of claim 1, which is N-ethyl-7-(2-methoxy-4-amino-5-chloro benzamido methyl)-8-azabicyclo (4,3,0) nonane.
Claim 7
Dependent Claim
32 words
A pharmaceutical composition containing as active principle a compound of claim 1 in an amount of 10 to 200 mg preferably of 20 to 100 mg, together with a suitable pharmaceutical carrier.
Claim 8
Dependent Claim
15 words
The composition of claim 6, wherein the active principle is the compound of claim 2.
Claim 9
Dependent Claim
15 words
The composition of claim 6, wherein the active principle is the compound of claim 3.
Claim 10
Dependent Claim
15 words
The composition of claim 6, wherein the active principle is the compound of claim 4.
Claim 11
Dependent Claim
15 words
The composition of claim 6, wherein the active principle is the compound of claim 5.
Claim 12
Dependent Claim
44 words
A method for treating a living animal body afflicted with gastroduodenal ulcer, gastric hypertension, nauseous syndromes of central origin or hypertension, comprising the step of administering an amount of a compound of claim 1 which is effective for the alleviation of the said condition.
Claim 13
Dependent Claim
15 words
The method of claim 11, wherein the compound administered is the compound of claim 2.
Claim 14
Dependent Claim
15 words
The method of claim 11, wherein the compound administered is the compound of claim 3.
Claim 15
Dependent Claim
15 words
The method of claim 11, wherein the compound administered is the compound of claim 4.
Claim 16
Dependent Claim
15 words
The method of claim 11, wherein the compound administered is the compound of claim 5.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-08-03 | 1980-02-02 | 1980-08-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-08-03 | 1984-02-02 | 1984-08-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-08-03 | 1988-02-02 | 1988-08-03 | $7700.00 | Window Closed / Lapsed |