US3972859A
Expired / Lapsed
US
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Novel decapeptide amide analogs of leuteinizing hormone-releasing hormone
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1975-03-04
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Granted: 1976-08-03
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Expires: 1995-03-04
Abstract
Abstract The novel decapeptide amide derivatives of the formula (Pyr)Glu-His-Trp-Ser-R.sub.1 -R.sub.2 -R.sub.3 -Arg-Pro-Gly-NH.sub.2 wherein R 1 is Tyr or Phe; R 2 is D-Nle, D-Nva, D-Abu, D-Phe, D-Ser, D-Thr or D-Met and R 3 is Leu, Ile or Nle have a strong ovulation inducing activity.
Inventors
- 👤 Masahiko Fujino
- 👤 Susumu Shinagawa
- 👤 Tsunehiko Fukuda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:21
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/10; C07K5/1002; C07K5/1005; C07K7/00; C07K7/04; C07K7/23; A; A61; A61K; A61K38/00; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/13
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
35 words
A compound of the formula (Pyr)Glu-His-Trp-Ser-R.sub.1 -R.sub.2 -R.sub.3 -Arg-Pro-Gly-NH.sub.2 wherein R 1 is Tyr or Phe; R 2 is D-Nle, D-Nva, D-Abu, D-Phe, D-Ser, D-Thr or D-Met and R 3 is Leu, Ile or Nle.
Claim 2
Dependent Claim
35 words
A compound of the formula (Pyr)Glu-His-Trp-Ser-R.sub.1 -R.sub.2 -R.sub.3 -Arg-Pro-Gly-NH.sub.2 wherein R 1 is Tyr or Phe; R 2 is D-Nle, D-Nva, D-Abu, D-Phe, D-Ser, D-Thr or D-Met and R 3 is Leu, Ile or Nle.
Claim 3
Dependent Claim
21 words
The compound as claimed in claim 1, wherein R 1 is Tyr, R 2 is D-Nle and R 3 is Leu.
Claim 4
Dependent Claim
21 words
The compound as claimed in claim 1, wherein R 1 is Tyr, R 2 is D-Ser and R 3 is Leu.
Claim 5
Dependent Claim
21 words
The compound as claimed in claim 1, wherein R 1 is Tyr, R 2 is D-Abu and R 3 is Leu.
Claim 6
Dependent Claim
21 words
The compound as claimed in claim 1, wherein R 1 is Tyr, R 2 is D-Nva and R 3 is Leu.
Claim 7
Dependent Claim
21 words
The compound as claimed in claim 1, wherein R 1 is Tyr, R 2 is D-Thr and R 3 is Leu.
Claim 8
Dependent Claim
21 words
The compound as claimed in claim 1, wherein R 1 is Tyr, R 2 is D-Phe and R 3 is Leu.
Claim 9
Dependent Claim
21 words
The compound as claimed in claim 1, wherein R 1 is Tyr, R 2 is D-Met and R 3 is Leu.
Claim 10
Dependent Claim
21 words
The compound as claimed in claim 1, wherein R 1 is Phe, R 2 is D-Phe and R 3 is Leu.
Claim 11
Dependent Claim
21 words
The compound as claimed in claim 1, wherein R 1 is Tyr, R 2 is D-Abu and R 3 is Ile.
Claim 12
Dependent Claim
20 words
The compound as claimed in claim 1, wherein R 1 is Phe, R 2 is D-Ser, R 3 is Nle.
Claim 13
Dependent Claim
20 words
The compound as claimed in claim 1, wherein R 1 is Phe, R 2 is D-Nle, R 3 is Nle.
Claim 14
Dependent Claim
20 words
The compound as claimed in claim 1, wherein R 1 is Phe, R 2 is D-Nva, R 3 is Ile.
Claim 15
Dependent Claim
20 words
The compound as claimed in claim 1, wherein R 1 is Phe, R 2 is D-Nva, R 3 is Leu.
References Cited (Backward Citations)
US3835108A
Cited
US3896104A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-08-03 | 1980-02-02 | 1980-08-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-08-03 | 1984-02-02 | 1984-08-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-08-03 | 1988-02-02 | 1988-08-03 | $7700.00 | Window Closed / Lapsed |