Patent US3971822A successfully refreshed from Google Patents.
US3971822A
Expired / Lapsed
US
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Aspartyl amide sweetening agents
Assignee: Tanabe Pharma Corp
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Filing: 1975-06-25
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Granted: 1976-07-27
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Expires: 1995-06-25
Abstract
Abstract An ester compound of the formula: R1 ¦ HOOC-CH2Y ¦¦ H2N-CH-C-NH-CH-CH2O-C-R2 [I] PARALLEL PARALLEL OO wherein R1 is hydrogen or hydroxy, R2 is alkyl of one to five carbon atoms, alkenyl of two to three carbon atoms, cycloalkyl of three to five carbon atoms or methylcycloalkyl of four to six carbon atoms and Y is alkylene of one to four carbon atoms, is disclosed. Several methods for preparing the compound[I] are also disclosed. The compound[I] is useful as a non-nutritive sweetening agent.
Inventors
- 👤 Ichiro Chibata
- 👤 Munetugu Miyoshi
- 👤 Hiroshi Ito
- 👤 Toshiyuki Fujii
- 👤 Keisuke Kawashima
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 23:47
CPC Classifications
C; C07; C07C; C07C271/00; C07C271/06; C07C271/08; C07C271/10; C07C271/22; Y; Y10; Y10S; Y10S530/00; Y10S530/801
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
55 words
A compound of the formula: ##EQU23## wherein R 1 is hydrogen or hydroxy, R 2 is alkyl of one to five carbon atoms, alkenyl of two to three carbon atoms, cycloalkyl of three to five carbon atoms or methylcycloalkyl of four to six carbon atoms, and Y is alkylene of one to four carbon atoms.
Claim 2
Dependent Claim
55 words
A compound of the formula: ##EQU23## wherein R 1 is hydrogen or hydroxy, R 2 is alkyl of one to five carbon atoms, alkenyl of two to three carbon atoms, cycloalkyl of three to five carbon atoms or methylcycloalkyl of four to six carbon atoms, and Y is alkylene of one to four carbon atoms.
Claim 3
Dependent Claim
49 words
The compound as claimed in claim 1, wherein R 1 is hydrogen or hydroxy, R 2 is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl and 1-methylbutyl, and Y is selected from the group consisting of methylene, ethylene, 1-methylethylene, 1-methylpropylene and 2-methylpropylene.
Claim 4
Dependent Claim
35 words
The compound as claimed in claim 1, wherein R 1 is hydrogen or hydroxy, R 2 is vinyl or isopropenyl, and Y is selected from the group consisting of methylene, ethylene, 1-methylethylene, 1-methylpropylene and 2*methylpropylene.
Claim 5
Dependent Claim
44 words
The compound as claimed in claim 1, wherein R 1 is hydrogen or hydroxy, R 2 is selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, 2-methylcyclopropyl and 2-methylcyclobutyl, and Y is selected from the group consisting of methylene, ethylene, 1-methylethylene, 1-methylpropylene and 2-methylpropylene.
Claim 6
Dependent Claim
18 words
The compound as claimed in claim 1, wherein the stereochemical configuration of said compound is L-D or L-DL.
Claim 7
Dependent Claim
18 words
The compound as claimed in claim 2, wherein the stereochemical configuration of said compound is L-D or L-DL.
Claim 8
Dependent Claim
18 words
The compound as claimed in claim 3, wherein the stereochemical configuration of said compound is L-D or L-DL.
Claim 9
Dependent Claim
18 words
The compound as claimed in claim 4, wherein the stereochemical configuration of said compound is L-D or L-DL.
Claim 10
Dependent Claim
30 words
The compound as claimed in claim 2, wherein R 1 is hydrogen, R 2 is methyl, Y is methylene, and the stereochemical configuration of said compound is L-D or L-DL.
Claim 11
Dependent Claim
30 words
The compound as claimed in claim 2, wherein R 1 is hydrogen, R 2 is ethyl, Y is methylene, and the stereochemical configuration of said compound is L-D or L-DL.
Claim 12
Dependent Claim
30 words
The compound as claimed in claim 2, wherein R 1 is hydrogen, R 2 is propyl, Y is methylene, and the stereochemical configuration of said compound is L-D or L-DL.
Claim 13
Dependent Claim
30 words
The compound as claimed in claim 2, wherein R 1 is hydrogen, R 2 is isopropyl, Y is methylene, and the stereochemical configuration of said compound is L-D or L-DL.
Claim 14
Dependent Claim
30 words
The compound as claimed in claim 2, wherein R 1 is hydrogen, R 2 is tert-butyl, Y is methylene, and the stereochemical configuration of said compound is L-D or L-DL.
Claim 15
Dependent Claim
30 words
The compound as claimed in claim 2, wherein R 1 is hydrogen, R 2 is isobutyl, Y is methylene, and the stereochemical configuratioin of said compound is L-D or L-DL.
Claim 16
Dependent Claim
30 words
The compound as claimed in claim 2, wherein R 1 is hydrogen, R 2 is sec-butyl, Y is methylene, and the stereochemical configuration of said compound is L-D or L-DL.
Claim 17
Dependent Claim
30 words
The compound as claimed in claim 2, wherein R 1 is hydrogen, R 2 is 1-methylbutyl, Y is methylene, and the stereochemical configuration of said compound is L-D or L-DL.
Claim 18
Dependent Claim
30 words
The compound as claimed in claim 2, wherein R 1 is hydrogen, R 2 is methyl, Y is 1-methylethylene, and the stereochemical configuration of said compound is L-D or L-DL.
Claim 19
Dependent Claim
30 words
The compound as claimed in claim 2, wherein R 1 is hydrogen, R 2 is ethyl, Y is 1-methylethylene, and the stereochemical configuration of said compound is L-D or L-DL.
Claim 20
Dependent Claim
27 words
The compound as claimed in claim 2, wherein R 1 is hydroxy, R 2 is ethyl, Y is methylene, and the stereochemical configuration is L-D or L-DL.
Claim 21
Dependent Claim
30 words
The compound as claimed in claim 3, wherein R 1 is hydrogen, R 2 is vinyl, Y is methylene, and the stereochemical configuration of said compound is L-D or L-DL.
Claim 22
Dependent Claim
30 words
The compound as claimed in claim 3, wherein R 1 is hydrogen, R 2 is isopropenyl, Y is methylene, and the stereochemical configuration of said compound is L-D or L-DL.
Claim 23
Dependent Claim
30 words
The compound as claimed in claim 4, wherein R 1 is hydrogen, R 2 is cyclopropyl, Y is methylene, and the stereochemical configuration of said compound is L-D or L-DL.
Claim 24
Dependent Claim
30 words
The compound as claimed in claim 4, wherein R 1 is hydrogen, R 2 is cyclobutyl, Y is methylene, and the stereochemical configuration of said compound is L-D or L-DL.
Claim 25
Dependent Claim
30 words
The compound as claimed in claim 4, wherein R 1 is hydrogen, R 2 is cyclopentyl, Y is methylene, and the stereochemical configuration of said compound is L-D or L-DL.
Claim 26
Dependent Claim
30 words
The compound as claimed in claim 4, wherein R 1 is hydrogen, R 2 is 2-methylcyclopropyl, Y is methylene, and the stereochemical configuration of said compound is L-D or L-DL.
Claim 27
Dependent Claim
30 words
The compound as claimed in claim 4, wherein R 1 is hydrogen, R 2 is 2-methylcyclobutyl, Y is methylene, and the stereochemical configuration of said compound is L-D or L-DL.
Claim 28
Dependent Claim
30 words
The compound as claimed in claim 4, wherein R 1 is hydroxy, R 2 is cyclopropyl, Y is methylene, and the stereochemical configuration of said compound is L-D or L-DL.
Claim 29
Dependent Claim
30 words
The compound as claimed in claim 4, wherein R 1 is hydrogen, R 2 is cyclobutyl, Y is methylene, and the stereochemical configuration of said compound is L-D or L-DL.
References Cited (Backward Citations)
US3496219A
Cited
US3907766A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-07-27 | 1980-01-26 | 1980-07-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-07-27 | 1984-01-26 | 1984-07-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-07-27 | 1988-01-26 | 1988-07-27 | $7700.00 | Window Closed / Lapsed |